FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380029470> ?p ?o ?g. }

• W4380029470 endingPage "6451" @default.
• W4380029470 startingPage "6451" @default.
• W4380029470 abstract "Abstract Purpose: Previous studies have investigated medium-chain fatty acids (MCFAs) as a part of saturated fat intake and risk of colorectal cancer (CRC). However, unlike long-chain saturated fatty acids, MCFAs possess many unique properties, including inhibition of pro-carcinogenic bacteria, biofilm formation, and induction of apoptosis. Further, C12:0 has been consistently shown in vitro to exhibit the most potent anti-microbial properties in a dose-dependent manner compared to other MCFAs. Black Americans have the highest CRC incidence and mortality across all racial subgroups in the US. In a predominantly low-income population, we aimed to examine whether dietary intake of MCFAs is associated with a reduced risk of CRC overall and among racial subgroups. Methods: The daily intake of total energy and individual nutrients, including MCFAs, was derived from a food frequency questionnaire. Multivariable-adjusted Cox regression was used to assess the associations between dietary intake of MCFAs and the risk of incident CRC during the 13.75-year follow up after adjustment for confounders. Results: Among 71,599 eligible participants, 868 incident CRC cases were identified (622 Blacks, 220 Whites and 26 other racial groups). High intake of C12:0 was significantly associated with a reduced risk of CRC only in White participants in a dose-response manner (for highest VS lowest quartile: HR, 0.37; 95% CI, 0.17 to 0.80; P for trend =0.0068). This protective association primarily appeared in White participants at high risk of CRC, such as those aged 50 years or older, overweight or obese, ever smokers, or living in a neighborhood with greater deprivation. On the other hand, we did not find a significant association in Black participants (HR, 0.87; 95% CI, 0.59 to 1.27); P for trend =0.72). However, there was a marginal linear association in Black participants with the lowest deprivation index while the association disappeared among Black participants with higher deprivation index. Finally, we found from the NHANES 2005-2016, a representative sample of the US general population, that Black Americans had the lowest intake of MCFAs across all racial subgroups and, overall, intakes of MCFAs decreased with reducing poverty-income ratio. No associations were found between intakes of C6:0, C8:0, or C10:0 and the risk of incident CRC overall or within the racial group. Conclusion: In this predominantly low-income population, increasing dietary C12:0 intake was associated with a substantially reduced risk of CRC only among White participants, but not in Black participants. This racial difference in associations may be because Black Americans consumed the lowest levels of MCFAs in all racial groups while a much higher proportion of Black participants had lactose intolerance and a lower proportion of them consumed lactose-free fermented foods. Citation Format: Lei Fan, Xiangzhu Zhu, Qingxia Chen, Xiang Huang, Mark D. Steinwandel, Martha Shrubsole, Qi Dai. Dietary medium-chain fatty acids and risk of incident colorectal cancer in a predominantly low-income population: a report from the Southern Community Cohort Study (SCCS) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6451." @default.
• W4380029470 created "2023-06-10" @default.
• W4380029470 creator A5011155701 @default.
• W4380029470 creator A5011757079 @default.
• W4380029470 creator A5030538673 @default.
• W4380029470 creator A5035695257 @default.
• W4380029470 creator A5046805154 @default.
• W4380029470 creator A5056193431 @default.
• W4380029470 creator A5057648011 @default.
• W4380029470 date "2023-04-04" @default.
• W4380029470 modified "2023-10-16" @default.
• W4380029470 title "Abstract 6451: Dietary medium-chain fatty acids and risk of incident colorectal cancer in a predominantly low-income population: a report from the Southern Community Cohort Study (SCCS)" @default.
• W4380029470 doi "https://doi.org/10.1158/1538-7445.am2023-6451" @default.
• W4380029470 hasPublicationYear "2023" @default.
• W4380029470 type Work @default.
• W4380029470 citedByCount "0" @default.
• W4380029470 crossrefType "journal-article" @default.
• W4380029470 hasAuthorship W4380029470A5011155701 @default.
• W4380029470 hasAuthorship W4380029470A5011757079 @default.
• W4380029470 hasAuthorship W4380029470A5030538673 @default.
• W4380029470 hasAuthorship W4380029470A5035695257 @default.
• W4380029470 hasAuthorship W4380029470A5046805154 @default.
• W4380029470 hasAuthorship W4380029470A5056193431 @default.
• W4380029470 hasAuthorship W4380029470A5057648011 @default.
• W4380029470 hasConcept C120665830 @default.
• W4380029470 hasConcept C121332964 @default.
• W4380029470 hasConcept C121608353 @default.
• W4380029470 hasConcept C126322002 @default.
• W4380029470 hasConcept C2779668873 @default.
• W4380029470 hasConcept C2780586474 @default.
• W4380029470 hasConcept C2908647359 @default.
• W4380029470 hasConcept C44249647 @default.
• W4380029470 hasConcept C511355011 @default.
• W4380029470 hasConcept C526805850 @default.
• W4380029470 hasConcept C61511704 @default.
• W4380029470 hasConcept C68443243 @default.
• W4380029470 hasConcept C71924100 @default.
• W4380029470 hasConcept C72563966 @default.
• W4380029470 hasConcept C77350462 @default.
• W4380029470 hasConcept C99454951 @default.
• W4380029470 hasConceptScore W4380029470C120665830 @default.
• W4380029470 hasConceptScore W4380029470C121332964 @default.
• W4380029470 hasConceptScore W4380029470C121608353 @default.
• W4380029470 hasConceptScore W4380029470C126322002 @default.
• W4380029470 hasConceptScore W4380029470C2779668873 @default.
• W4380029470 hasConceptScore W4380029470C2780586474 @default.
• W4380029470 hasConceptScore W4380029470C2908647359 @default.
• W4380029470 hasConceptScore W4380029470C44249647 @default.
• W4380029470 hasConceptScore W4380029470C511355011 @default.
• W4380029470 hasConceptScore W4380029470C526805850 @default.
• W4380029470 hasConceptScore W4380029470C61511704 @default.
• W4380029470 hasConceptScore W4380029470C68443243 @default.
• W4380029470 hasConceptScore W4380029470C71924100 @default.
• W4380029470 hasConceptScore W4380029470C72563966 @default.
• W4380029470 hasConceptScore W4380029470C77350462 @default.
• W4380029470 hasConceptScore W4380029470C99454951 @default.
• W4380029470 hasIssue "7_Supplement" @default.
• W4380029470 hasLocation W43800294701 @default.
• W4380029470 hasOpenAccess W4380029470 @default.
• W4380029470 hasPrimaryLocation W43800294701 @default.
• W4380029470 hasRelatedWork W1988893882 @default.
• W4380029470 hasRelatedWork W2008211876 @default.
• W4380029470 hasRelatedWork W2022666964 @default.
• W4380029470 hasRelatedWork W2090617933 @default.
• W4380029470 hasRelatedWork W2348993855 @default.
• W4380029470 hasRelatedWork W2382270101 @default.
• W4380029470 hasRelatedWork W2411416190 @default.
• W4380029470 hasRelatedWork W2606181536 @default.
• W4380029470 hasRelatedWork W2612506575 @default.
• W4380029470 hasRelatedWork W3095172861 @default.
• W4380029470 hasVolume "83" @default.
• W4380029470 isParatext "false" @default.
• W4380029470 isRetracted "false" @default.
• W4380029470 workType "article" @default.