FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380046868> ?p ?o ?g. }

• W4380046868 endingPage "532" @default.
• W4380046868 startingPage "520" @default.
• W4380046868 abstract "The present study assessed two different plant parts (leaves and tubers) of Arum italicum species growing in Northeast Algeria for their phytochemical composition and pharmacological effects. The phytochemical content was determined using ultra-high-performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer (UHPLC-DAD-ESI/MS). The results revealed that the tuber extract was rich in lignans with a fraxiresinol glycoside as the major compound. In contrast, the leaf extract was rich in flavonoid glycosides, described for the first time in the aerial part of this species. The extract’s inhibitory activity against key enzymes was linked to hyperglycemia, α-glucosidase, and α-amylase, and their ability to inhibit the growth of human gastric carcinoma (AGS) and lung carcinoma (A549) cancer cell lines was also assessed. A cell line morphology study was also conducted with the most effective extract. The chromatin status of the cells was evaluated using DAPI, while the cytoplasmic morphology was evaluated using phalloidin. The tuber extract generally inhibited α-glucosidase and α-amylase enzymes more efficiently than the leaf extract. Its inhibition effect against the α-glucosidase was significantly higher when compared to the standard acarbose. The tuber extract also caused more viability loss of AGS and A549 cancer cells than the leaf extract in the cytotoxicity assay. In conclusion, our findings show that, compared to the leaf extract, the tuber extract exhibited more pronounced biological effects. The strong inhibitory potential of the tuber extract against the α-glucosidase enzyme should also be highlighted, which suggests it is a good candidate for discovering new antidiabetic agents." @default.
• W4380046868 created "2023-06-10" @default.
• W4380046868 creator A5002757956 @default.
• W4380046868 creator A5016072263 @default.
• W4380046868 creator A5017562043 @default.
• W4380046868 creator A5031810675 @default.
• W4380046868 creator A5040194711 @default.
• W4380046868 creator A5059080868 @default.
• W4380046868 creator A5065210033 @default.
• W4380046868 creator A5082542075 @default.
• W4380046868 date "2023-06-07" @default.
• W4380046868 modified "2023-10-16" @default.
• W4380046868 title "A Comparative Analysis between the Phenolic Content, Key Enzyme Inhibitory Potential, and Cytotoxic Activity of Arum italicum Miller in Two Different Organs" @default.
• W4380046868 cites W1135037422 @default.
• W4380046868 cites W1479698458 @default.
• W4380046868 cites W1488973351 @default.
• W4380046868 cites W1718201877 @default.
• W4380046868 cites W1981151886 @default.
• W4380046868 cites W1985960034 @default.
• W4380046868 cites W1996974691 @default.
• W4380046868 cites W2061801920 @default.
• W4380046868 cites W2067365681 @default.
• W4380046868 cites W2067599801 @default.
• W4380046868 cites W2077215981 @default.
• W4380046868 cites W2113267645 @default.
• W4380046868 cites W2124385784 @default.
• W4380046868 cites W2144095756 @default.
• W4380046868 cites W2151972443 @default.
• W4380046868 cites W2167279371 @default.
• W4380046868 cites W2168195570 @default.
• W4380046868 cites W2239219009 @default.
• W4380046868 cites W2300648632 @default.
• W4380046868 cites W2389513897 @default.
• W4380046868 cites W2440750086 @default.
• W4380046868 cites W2500484056 @default.
• W4380046868 cites W2560247459 @default.
• W4380046868 cites W2578656048 @default.
• W4380046868 cites W2592740457 @default.
• W4380046868 cites W2606532724 @default.
• W4380046868 cites W2613570374 @default.
• W4380046868 cites W2752731702 @default.
• W4380046868 cites W2902641822 @default.
• W4380046868 cites W2913805825 @default.
• W4380046868 cites W2955261966 @default.
• W4380046868 cites W2981060152 @default.
• W4380046868 cites W2996788436 @default.
• W4380046868 cites W3039700603 @default.
• W4380046868 cites W3047416913 @default.
• W4380046868 cites W3138492147 @default.
• W4380046868 cites W3196605154 @default.
• W4380046868 cites W4214920424 @default.
• W4380046868 cites W4220954632 @default.
• W4380046868 cites W4242975213 @default.
• W4380046868 cites W4311852513 @default.
• W4380046868 doi "https://doi.org/10.3390/ijpb14020041" @default.
• W4380046868 hasPublicationYear "2023" @default.
• W4380046868 type Work @default.
• W4380046868 citedByCount "0" @default.
• W4380046868 crossrefType "journal-article" @default.
• W4380046868 hasAuthorship W4380046868A5002757956 @default.
• W4380046868 hasAuthorship W4380046868A5016072263 @default.
• W4380046868 hasAuthorship W4380046868A5017562043 @default.
• W4380046868 hasAuthorship W4380046868A5031810675 @default.
• W4380046868 hasAuthorship W4380046868A5040194711 @default.
• W4380046868 hasAuthorship W4380046868A5059080868 @default.
• W4380046868 hasAuthorship W4380046868A5065210033 @default.
• W4380046868 hasAuthorship W4380046868A5082542075 @default.
• W4380046868 hasBestOaLocation W43800468681 @default.
• W4380046868 hasConcept C170835558 @default.
• W4380046868 hasConcept C181199279 @default.
• W4380046868 hasConcept C185592680 @default.
• W4380046868 hasConcept C194671627 @default.
• W4380046868 hasConcept C195475562 @default.
• W4380046868 hasConcept C2776617576 @default.
• W4380046868 hasConcept C2778004101 @default.
• W4380046868 hasConcept C2779054382 @default.
• W4380046868 hasConcept C55493867 @default.
• W4380046868 hasConcept C556039675 @default.
• W4380046868 hasConcept C59822182 @default.
• W4380046868 hasConcept C71924100 @default.
• W4380046868 hasConcept C86803240 @default.
• W4380046868 hasConceptScore W4380046868C170835558 @default.
• W4380046868 hasConceptScore W4380046868C181199279 @default.
• W4380046868 hasConceptScore W4380046868C185592680 @default.
• W4380046868 hasConceptScore W4380046868C194671627 @default.
• W4380046868 hasConceptScore W4380046868C195475562 @default.
• W4380046868 hasConceptScore W4380046868C2776617576 @default.
• W4380046868 hasConceptScore W4380046868C2778004101 @default.
• W4380046868 hasConceptScore W4380046868C2779054382 @default.
• W4380046868 hasConceptScore W4380046868C55493867 @default.
• W4380046868 hasConceptScore W4380046868C556039675 @default.
• W4380046868 hasConceptScore W4380046868C59822182 @default.
• W4380046868 hasConceptScore W4380046868C71924100 @default.
• W4380046868 hasConceptScore W4380046868C86803240 @default.
• W4380046868 hasIssue "2" @default.
• W4380046868 hasLocation W43800468681 @default.
• W4380046868 hasOpenAccess W4380046868 @default.
• W4380046868 hasPrimaryLocation W43800468681 @default.

• next