Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380047784> ?p ?o ?g. }
- W4380047784 endingPage "733" @default.
- W4380047784 startingPage "733" @default.
- W4380047784 abstract "Dry eye disease (DED) can be extremely distressing and is common in type 2 diabetes (T2D). To investigate potential biomarkers of DED in T2D, panels of proteins in tears, alongside clinical signs and symptoms of DED, were assessed. Patients were classified into four groups: T2D + DED (n = 47), T2D-only (n = 41), DED-only (n = 17) and healthy controls (n = 17). All patients underwent the Ocular Surface Disease Index (OSDI) and Dry Eye-Related Quality of Life (DEQS) questionnaires, tear evaporation rate (TER), fluorescein tear break-up time (fTBUT), corneal fluorescein staining (CFS) and Schirmer 1 test assessments. Six metabolic proteins and 14 inflammatory cytokines were analyzed with multiplex bead analysis. Interleukin (IL)-6 and IL-8 concentrations in tears were significantly higher in the T2D + DED group, and these biomarkers were positively correlated with CFS. In addition, tear IL-6 was negatively correlated with fTBUT in the T2D + DED group. Clinical signs of DED in the T2D + DED group were similar to the DED-only group. The T2D + DED group had more patients with moderate and severe DED (versus the DED-only group), suggesting a different pathogenesis for DED in T2D versus DED-only. Therefore, IL-6 and IL-8 could potentially be diagnostic biomarkers of DED in T2D." @default.
- W4380047784 created "2023-06-10" @default.
- W4380047784 creator A5016799143 @default.
- W4380047784 creator A5034426801 @default.
- W4380047784 creator A5045991725 @default.
- W4380047784 creator A5088134928 @default.
- W4380047784 date "2023-06-08" @default.
- W4380047784 modified "2023-10-16" @default.
- W4380047784 title "Tear Fluid Biomarkers and Quality of Life in People with Type 2 Diabetes and Dry Eye Disease" @default.
- W4380047784 cites W1489932363 @default.
- W4380047784 cites W1971052157 @default.
- W4380047784 cites W1981712821 @default.
- W4380047784 cites W1984490871 @default.
- W4380047784 cites W2018397220 @default.
- W4380047784 cites W2024925317 @default.
- W4380047784 cites W2027794314 @default.
- W4380047784 cites W2054186928 @default.
- W4380047784 cites W2057311987 @default.
- W4380047784 cites W2063507107 @default.
- W4380047784 cites W2067057261 @default.
- W4380047784 cites W2077510441 @default.
- W4380047784 cites W2079978187 @default.
- W4380047784 cites W2095452918 @default.
- W4380047784 cites W2111878923 @default.
- W4380047784 cites W2115345791 @default.
- W4380047784 cites W2152215219 @default.
- W4380047784 cites W2162065037 @default.
- W4380047784 cites W2298184967 @default.
- W4380047784 cites W2345167694 @default.
- W4380047784 cites W2461853521 @default.
- W4380047784 cites W2471583846 @default.
- W4380047784 cites W2480321230 @default.
- W4380047784 cites W2508683728 @default.
- W4380047784 cites W2587868813 @default.
- W4380047784 cites W2594087437 @default.
- W4380047784 cites W2738160893 @default.
- W4380047784 cites W2790457304 @default.
- W4380047784 cites W2792166662 @default.
- W4380047784 cites W2800567958 @default.
- W4380047784 cites W2802344932 @default.
- W4380047784 cites W2889512770 @default.
- W4380047784 cites W2911271617 @default.
- W4380047784 cites W2944627500 @default.
- W4380047784 cites W2962519153 @default.
- W4380047784 cites W3008402997 @default.
- W4380047784 cites W3008492978 @default.
- W4380047784 cites W3008973283 @default.
- W4380047784 cites W3015422347 @default.
- W4380047784 cites W3085870433 @default.
- W4380047784 cites W3092013927 @default.
- W4380047784 cites W3110671166 @default.
- W4380047784 cites W3111531467 @default.
- W4380047784 cites W3112779562 @default.
- W4380047784 cites W3136705191 @default.
- W4380047784 cites W3138711074 @default.
- W4380047784 cites W3151275769 @default.
- W4380047784 cites W3164827680 @default.
- W4380047784 cites W3173949848 @default.
- W4380047784 cites W4200026682 @default.
- W4380047784 cites W4220707929 @default.
- W4380047784 cites W4223543111 @default.
- W4380047784 cites W4238714725 @default.
- W4380047784 cites W4280603278 @default.
- W4380047784 cites W4291982393 @default.
- W4380047784 cites W4293857795 @default.
- W4380047784 cites W4294167990 @default.
- W4380047784 cites W4322503082 @default.
- W4380047784 doi "https://doi.org/10.3390/metabo13060733" @default.
- W4380047784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37367891" @default.
- W4380047784 hasPublicationYear "2023" @default.
- W4380047784 type Work @default.
- W4380047784 citedByCount "1" @default.
- W4380047784 crossrefType "journal-article" @default.
- W4380047784 hasAuthorship W4380047784A5016799143 @default.
- W4380047784 hasAuthorship W4380047784A5034426801 @default.
- W4380047784 hasAuthorship W4380047784A5045991725 @default.
- W4380047784 hasAuthorship W4380047784A5088134928 @default.
- W4380047784 hasBestOaLocation W43800477841 @default.
- W4380047784 hasConcept C118487528 @default.
- W4380047784 hasConcept C126322002 @default.
- W4380047784 hasConcept C134018914 @default.
- W4380047784 hasConcept C203014093 @default.
- W4380047784 hasConcept C2777165675 @default.
- W4380047784 hasConcept C2777180221 @default.
- W4380047784 hasConcept C2778275304 @default.
- W4380047784 hasConcept C2779134260 @default.
- W4380047784 hasConcept C2780942790 @default.
- W4380047784 hasConcept C2781188995 @default.
- W4380047784 hasConcept C2781302119 @default.
- W4380047784 hasConcept C555293320 @default.
- W4380047784 hasConcept C60644358 @default.
- W4380047784 hasConcept C71924100 @default.
- W4380047784 hasConcept C86803240 @default.
- W4380047784 hasConcept C90924648 @default.
- W4380047784 hasConceptScore W4380047784C118487528 @default.
- W4380047784 hasConceptScore W4380047784C126322002 @default.
- W4380047784 hasConceptScore W4380047784C134018914 @default.
- W4380047784 hasConceptScore W4380047784C203014093 @default.