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- W4380051838 endingPage "991" @default.
- W4380051838 startingPage "991" @default.
- W4380051838 abstract "Japanese cedar (JC, Cryptomeria japonica) pollen allergens are the primary cause of JC pollinosis, a widespread seasonal allergic disorder and a significant public health issue in Japan. Nevertheless, rare information on repressing the pollen allergens released from JC pollen is available. This study aims to validate the repression of allergen Cry j 1 (the dominant JC pollen allergen that triggers JC pollinosis) using todomatsu oil produced from Abies sachalinensis waste, through surface plasmon resonance (SPR) experiments, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and blind docking simulation. The findings revealed that todomatsu oil reduces the antibody reactivity and content of allergen Cry j 1 by 85.96% and 42.12%, respectively. The docking modeling suggested that alkyl hydrophobic forces, pi–sigma bonding, and hydrogen bonding are the principal motivating forces for todomatsu oil components to dock with allergen Cry j 1. More than 50% of the amino-acid residues docked by each todomatsu oil component (except α-pinene) are hydrophobic. Furthermore, oil components, especially β-maaliene, exhibited potent repression of allergen Cry j 1. Consequently, todomatsu oil, due to its inexpensive, available, convenient, and ecologically beneficial nature, is a viable measure to repress allergen Cry j 1." @default.
- W4380051838 created "2023-06-10" @default.
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- W4380051838 creator A5076608158 @default.
- W4380051838 creator A5090671117 @default.
- W4380051838 date "2023-06-07" @default.
- W4380051838 modified "2023-09-26" @default.
- W4380051838 title "Research on Repressing Allergen Cry j 1 Released from Japanese Cedar Pollen Using Todomatsu Oil" @default.
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- W4380051838 doi "https://doi.org/10.3390/atmos14060991" @default.
- W4380051838 hasPublicationYear "2023" @default.
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