FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380052213> ?p ?o ?g. }

• W4380052213 endingPage "330" @default.
• W4380052213 startingPage "314" @default.
• W4380052213 abstract "The chronic use of hypotensive agents eventually leads to ocular surface damage and poor patient compliance during glaucoma management. Thus, new sustained drug delivery systems are needed. This work aimed to develop osmoprotective latanoprost-loaded microemulsion formulations as new potential glaucoma treatments with ocular surface protective properties. The microemulsions were characterized and latanoprost encapsulation efficacy determined. In-vitro tolerance, osmoprotective efficacy, cell internalization as well as cell-microemulsion interactions and distribution were performed. In vivo hypotensive activity was conducted in rabbits to assess intraocular pressure reduction and relative ocular bioavailability. Physicochemical characterization showed nanodroplet sizes within 20-30 nm, being in vitro tolerance within 80 and 100% viability in corneal and conjunctival cells. Besides, microemulsions exhibited higher protection under hypertonic conditions than untreated cells. Cell fluorescence lasted for 11 days after short exposure to coumarin-loaded microemulsions (5 min) showing extensive internalization in different cell compartments by electronic microscopy. In vivo studies exhibited that a single instillation of latanoprost-loaded microemulsions reduced the intraocular pressure for several days (4-6 days without polymer and 9-13 days with polymers). Relative ocular bioavailability was 4.5 and 19 times higher than the marketed formulation. These findings suggest the use of these microemulsions as potential combined strategies for extended surface protection and glaucoma treatment." @default.
• W4380052213 created "2023-06-10" @default.
• W4380052213 creator A5024264311 @default.
• W4380052213 creator A5030442986 @default.
• W4380052213 creator A5030634294 @default.
• W4380052213 creator A5049165904 @default.
• W4380052213 creator A5051335844 @default.
• W4380052213 creator A5065595028 @default.
• W4380052213 creator A5073742899 @default.
• W4380052213 date "2023-07-01" @default.
• W4380052213 modified "2023-10-02" @default.
• W4380052213 title "New trends towards glaucoma treatment: Topical osmoprotective microemulsions loaded with latanoprost" @default.
• W4380052213 cites W1887592496 @default.
• W4380052213 cites W1908580730 @default.
• W4380052213 cites W1966836301 @default.
• W4380052213 cites W1970531479 @default.
• W4380052213 cites W1983720255 @default.
• W4380052213 cites W1984089625 @default.
• W4380052213 cites W1984127381 @default.
• W4380052213 cites W1990509643 @default.
• W4380052213 cites W2003310190 @default.
• W4380052213 cites W2007667055 @default.
• W4380052213 cites W2018516156 @default.
• W4380052213 cites W2026940257 @default.
• W4380052213 cites W2060437775 @default.
• W4380052213 cites W2067199548 @default.
• W4380052213 cites W2081833592 @default.
• W4380052213 cites W2087828608 @default.
• W4380052213 cites W2092359652 @default.
• W4380052213 cites W2112605601 @default.
• W4380052213 cites W2157634286 @default.
• W4380052213 cites W2163214325 @default.
• W4380052213 cites W2185914194 @default.
• W4380052213 cites W2329019407 @default.
• W4380052213 cites W2337762776 @default.
• W4380052213 cites W2344744859 @default.
• W4380052213 cites W2412773004 @default.
• W4380052213 cites W2522467597 @default.
• W4380052213 cites W2549391624 @default.
• W4380052213 cites W2582416018 @default.
• W4380052213 cites W2605156143 @default.
• W4380052213 cites W2612844042 @default.
• W4380052213 cites W2739410682 @default.
• W4380052213 cites W2748741293 @default.
• W4380052213 cites W2757996766 @default.
• W4380052213 cites W2761604622 @default.
• W4380052213 cites W2778177407 @default.
• W4380052213 cites W2901787904 @default.
• W4380052213 cites W2947293085 @default.
• W4380052213 cites W2970727614 @default.
• W4380052213 cites W2998814241 @default.
• W4380052213 cites W3023105196 @default.
• W4380052213 cites W3039030773 @default.
• W4380052213 cites W3080549322 @default.
• W4380052213 cites W3110220146 @default.
• W4380052213 cites W3112659503 @default.
• W4380052213 cites W3120827930 @default.
• W4380052213 cites W3123472196 @default.
• W4380052213 cites W3175498089 @default.
• W4380052213 cites W3176068306 @default.
• W4380052213 cites W3188089643 @default.
• W4380052213 cites W4283329995 @default.
• W4380052213 cites W4376595529 @default.
• W4380052213 doi "https://doi.org/10.1016/j.jtos.2023.05.013" @default.
• W4380052213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37295473" @default.
• W4380052213 hasPublicationYear "2023" @default.
• W4380052213 type Work @default.
• W4380052213 citedByCount "0" @default.
• W4380052213 crossrefType "journal-article" @default.
• W4380052213 hasAuthorship W4380052213A5024264311 @default.
• W4380052213 hasAuthorship W4380052213A5030442986 @default.
• W4380052213 hasAuthorship W4380052213A5030634294 @default.
• W4380052213 hasAuthorship W4380052213A5049165904 @default.
• W4380052213 hasAuthorship W4380052213A5051335844 @default.
• W4380052213 hasAuthorship W4380052213A5065595028 @default.
• W4380052213 hasAuthorship W4380052213A5073742899 @default.
• W4380052213 hasBestOaLocation W43800522131 @default.
• W4380052213 hasConcept C118487528 @default.
• W4380052213 hasConcept C150903083 @default.
• W4380052213 hasConcept C178790620 @default.
• W4380052213 hasConcept C181389837 @default.
• W4380052213 hasConcept C185592680 @default.
• W4380052213 hasConcept C190119865 @default.
• W4380052213 hasConcept C207001950 @default.
• W4380052213 hasConcept C2776740260 @default.
• W4380052213 hasConcept C2778190193 @default.
• W4380052213 hasConcept C2778527774 @default.
• W4380052213 hasConcept C2779820397 @default.
• W4380052213 hasConcept C2781092963 @default.
• W4380052213 hasConcept C55493867 @default.
• W4380052213 hasConcept C58226133 @default.
• W4380052213 hasConcept C71924100 @default.
• W4380052213 hasConcept C86803240 @default.
• W4380052213 hasConcept C98274493 @default.
• W4380052213 hasConceptScore W4380052213C118487528 @default.
• W4380052213 hasConceptScore W4380052213C150903083 @default.
• W4380052213 hasConceptScore W4380052213C178790620 @default.
• W4380052213 hasConceptScore W4380052213C181389837 @default.

• next