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• W4380052383 endingPage "108018" @default.
• W4380052383 startingPage "108018" @default.
• W4380052383 abstract "Microcystins (MCs), a group of most widespread freshwater cyanotoxins that possess strong neurotoxicity, can adversely affect brain structures and functions and are linked to neurodegenerative diseases. Despite the essential role of lipids in brain structures and functions, the brain lipidome profile of mammals exposed to MCs remains unexplored, hindering a clear understanding of the neurotoxic effects of MCs and underlying mechanisms. In this study, we performed untargeted lipidomic profiling using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) on the prefrontal cortex and hippocampus of mice orally exposed to 30 and 300 μg/kg body mass/day of microcystin-leucine arginine (MC-LR) for 180 days to evaluate the impacts of MC-LR on the brain lipidome profile and functions. Our results show that MC-LR resulted in a decline in cognitive parameters, as assessed by the Morris water maze test. Interestingly, apparent neurodegenerative changes were observed in the prefrontal cortex, but not in the hippocampus. Comprehensive lipidomic analyses uncovered profound, region-specific changes in the phospholipid and sphingolipid profile at the levels of lipid subclasses, lipid species, and fatty acyl composition. These changes showed overall decrease trends of lipid content in the prefrontal cortex yet increasing trends in the hippocampus. We identified distinct transcriptional regulations of lipid metabolism and apoptosis by MC-LR in the two regions, which appeared to underlie the neurodegenerative changes. Collectively, this study uncovers region-specific changes in the brain lipidome profile and functions induced by MCs, shedding light on the role of lipid dysfunction in neurotoxicity mechanism of MCs." @default.
• W4380052383 created "2023-06-10" @default.
• W4380052383 creator A5016786612 @default.
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• W4380052383 creator A5092126819 @default.
• W4380052383 date "2023-07-01" @default.
• W4380052383 modified "2023-10-17" @default.
• W4380052383 title "First insights into region-specific lipidome alterations of prefrontal cortex and hippocampus of mice exposed chronically to microcystins" @default.
• W4380052383 cites W14197507 @default.
• W4380052383 cites W1829380695 @default.
• W4380052383 cites W1964991486 @default.
• W4380052383 cites W1968177047 @default.
• W4380052383 cites W1969770915 @default.
• W4380052383 cites W1973932627 @default.
• W4380052383 cites W1978671354 @default.
• W4380052383 cites W1981000616 @default.
• W4380052383 cites W1982959887 @default.
• W4380052383 cites W1998799810 @default.
• W4380052383 cites W2007952700 @default.
• W4380052383 cites W2020616137 @default.
• W4380052383 cites W2031687154 @default.
• W4380052383 cites W2032683445 @default.
• W4380052383 cites W2043099341 @default.
• W4380052383 cites W2043642541 @default.
• W4380052383 cites W2055784392 @default.
• W4380052383 cites W2058345372 @default.
• W4380052383 cites W2062897750 @default.
• W4380052383 cites W2071256705 @default.
• W4380052383 cites W2073364665 @default.
• W4380052383 cites W2075293189 @default.
• W4380052383 cites W2075748018 @default.
• W4380052383 cites W2078530990 @default.
• W4380052383 cites W2100192252 @default.
• W4380052383 cites W2103976813 @default.
• W4380052383 cites W2104227586 @default.
• W4380052383 cites W2105632792 @default.
• W4380052383 cites W2106969896 @default.
• W4380052383 cites W2110465984 @default.
• W4380052383 cites W2121276791 @default.
• W4380052383 cites W2135551353 @default.
• W4380052383 cites W2148918646 @default.
• W4380052383 cites W2158767137 @default.
• W4380052383 cites W2160661300 @default.
• W4380052383 cites W2162626874 @default.
• W4380052383 cites W2166313059 @default.
• W4380052383 cites W2173085120 @default.
• W4380052383 cites W2267459830 @default.
• W4380052383 cites W2321463742 @default.
• W4380052383 cites W2334356172 @default.
• W4380052383 cites W2513964174 @default.
• W4380052383 cites W2520417383 @default.
• W4380052383 cites W2539489225 @default.
• W4380052383 cites W2589881680 @default.
• W4380052383 cites W2757651286 @default.
• W4380052383 cites W2790705492 @default.
• W4380052383 cites W2802341640 @default.
• W4380052383 cites W2808694346 @default.
• W4380052383 cites W2907066239 @default.
• W4380052383 cites W2910046601 @default.
• W4380052383 cites W2918301287 @default.
• W4380052383 cites W2922685652 @default.
• W4380052383 cites W2944103515 @default.
• W4380052383 cites W2954926926 @default.
• W4380052383 cites W2964335968 @default.
• W4380052383 cites W2965720267 @default.
• W4380052383 cites W2972772948 @default.
• W4380052383 cites W2977702609 @default.
• W4380052383 cites W2979808541 @default.
• W4380052383 cites W2987211514 @default.
• W4380052383 cites W2997422246 @default.
• W4380052383 cites W3084765988 @default.
• W4380052383 cites W3093198230 @default.
• W4380052383 cites W3096611573 @default.
• W4380052383 cites W3111719647 @default.
• W4380052383 cites W3120409146 @default.
• W4380052383 cites W3132250580 @default.
• W4380052383 cites W3132294960 @default.
• W4380052383 cites W3172651089 @default.
• W4380052383 cites W3182593225 @default.
• W4380052383 cites W3194713752 @default.
• W4380052383 cites W3198638776 @default.
• W4380052383 cites W3208640747 @default.
• W4380052383 cites W4211010233 @default.
• W4380052383 cites W4214766070 @default.
• W4380052383 cites W4220748463 @default.
• W4380052383 cites W4283364142 @default.
• W4380052383 cites W4285086629 @default.
• W4380052383 cites W4296163350 @default.
• W4380052383 cites W4323261949 @default.
• W4380052383 doi "https://doi.org/10.1016/j.envint.2023.108018" @default.
• W4380052383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37329758" @default.

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