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• W4380053088 abstract "Phacomatosis pigmentokeratotica (PPK), an epidermal nevus syndrome, is characterized by the coexistence of nevus spilus and nevus sebaceus. Within the nevus spilus, an extensive range of atypical nevi of different morphologies may manifest. Pigmented lesions may fulfill the ABCDE criteria for melanoma, which may prompt a physician to perform a full-thickness biopsy.Excisions result in pain, mental distress, and physical disfigurement. For patients with a significant number of nevi with morphologic atypia, it may not be physically feasible to biopsy a large number of lesions. Optical coherence tomography (OCT) is a non-invasive imaging modality that may be used to visualize non-melanoma and melanoma skin cancers.In this study, we used OCT to image pigmented lesions with morphologic atypia in a patient with PPK and assessed their quantitative optical properties compared to OCT cases of melanoma. We implement a support vector machine learning algorithm with Gabor wavelet transformation algorithm during post-image processing to extract optical properties and calculate attenuation coefficients.The algorithm was trained and tested to extract and classify textural data.We conclude that implementing this post-imaging machine learning algorithm to OCT images of pigmented lesions in PPK has been able to successfully confirm benign optical properties. Additionally, we identified remarkable differences in attenuation coefficient values and tissue optical characteristics, further defining separating benign features of pigmented lesions in PPK from malignant features." @default.
• W4380053088 created "2023-06-10" @default.
• W4380053088 creator A5007724052 @default.
• W4380053088 creator A5010085516 @default.
• W4380053088 creator A5016648884 @default.
• W4380053088 creator A5017435560 @default.
• W4380053088 creator A5022660341 @default.
• W4380053088 creator A5029615982 @default.
• W4380053088 date "2023-05-30" @default.
• W4380053088 modified "2023-09-26" @default.
• W4380053088 title "Optical coherence tomography confirms non‐malignant pigmented lesions in phacomatosis pigmentokeratotica using a support vector machine learning algorithm" @default.
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