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• W4380077445 abstract "Abstract G-quadruplexes (G4s) regulate DNA replication and gene transcription, and are enriched in promoters without fully appreciated functional relevance. Here we show high selection pressure on putative G4 (pG4) forming sequences in promoters through investigating genetic and genomic data. Analyses of 76,156 whole-genome sequences reveal that G-tracts and connecting loops in promoter pG4s display lower or higher allele frequencies, respectively, than pG4-flanking regions, and central guanines (Gs) in G-tracts show higher selection pressure than other Gs. Additionally, pG4-promoters produce over 72.4% of transcripts, and promoter G4-containing genes are expressed at relatively high levels. Most genes repressed by TMPyP4, a G4-ligand, regulate epigenetic processes, and promoter G4s are enriched with gene activation histone marks, chromatin remodeler and transcription factor binding sites. Consistently, cis -expression quantitative trait loci ( cis -eQTLs) are enriched in promoter pG4s and their G-tracts. Overall, our study demonstrates selective constraint of promoter G4s and reinforces their stimulative role in gene expression." @default.
• W4380077445 created "2023-06-10" @default.
• W4380077445 creator A5000593102 @default.
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• W4380077445 date "2023-06-10" @default.
• W4380077445 modified "2023-09-27" @default.
• W4380077445 title "Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation" @default.
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• W4380077445 cites W2018838463 @default.
• W4380077445 cites W2035451872 @default.
• W4380077445 cites W2035618305 @default.
• W4380077445 cites W2049033120 @default.
• W4380077445 cites W2059306569 @default.
• W4380077445 cites W2081827253 @default.
• W4380077445 cites W2092424765 @default.
• W4380077445 cites W2093320042 @default.
• W4380077445 cites W2094074349 @default.
• W4380077445 cites W2097372529 @default.
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• W4380077445 cites W2108234281 @default.
• W4380077445 cites W2108744961 @default.
• W4380077445 cites W2112132489 @default.
• W4380077445 cites W2116790427 @default.
• W4380077445 cites W2117446594 @default.
• W4380077445 cites W2118758121 @default.
• W4380077445 cites W2124165778 @default.
• W4380077445 cites W2128505445 @default.
• W4380077445 cites W2132393729 @default.
• W4380077445 cites W2140784970 @default.
• W4380077445 cites W2155773930 @default.
• W4380077445 cites W2163600007 @default.
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• W4380077445 cites W2413043813 @default.
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• W4380077445 doi "https://doi.org/10.1038/s42003-023-05015-6" @default.
• W4380077445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37301913" @default.
• W4380077445 hasPublicationYear "2023" @default.
• W4380077445 type Work @default.
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