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- W4380077551 abstract "Background: Adenoid cystic carcinoma (ACC) is a common tumor of the head and neck. It is characterized by slow growth, strong invasiveness, easy recurrence and distant organ metastasis. Bcl-2 and NF- κ B are indicated to relate to tumor growth, proliferation and apoptosis. This study aims to analyze the relationship between Bcl-2, NF- κ B and ACC. Methods: With ELISA method to detect Bcl-2 and NF- κ B expression in the blood of patients with ACC, patients with benign adenoma and healthy controls, and the expression of Bcl-2 and NF- κ B in tissues was detected by immunohistochemistry, and their relationship with ACC was analyzed. relevance. Relationships between clinicopathological features. Results: The levels of Bcl-2 (4.16±1.34 ng/ml) and NF- κ B (4.47 ± 1.37 ng/ml) as well as positive rates of Bcl-2 and NF- κ B (87.5% and 85%) were significantly elevated in the ACC group ( P <0.05). Bcl-2 was positively correlated with NF- κ B ( P <0.05). Of note, Bcl-2 and NF- κ B expressions were correlated with the incidence frequency, histological type, clinical stage, lymph node metastasis and distant metastasis of ACC patients ( P < 0.05) as the distant metastasis is an independent risk factor. Conclusion: In summary, Bcl-2 and NF- κ B expression in ACC patients is associated with the clinicopathological features of ACC." @default.
- W4380077551 created "2023-06-10" @default.
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- W4380077551 date "2023-03-01" @default.
- W4380077551 modified "2023-10-16" @default.
- W4380077551 title "Expression of Lymphoma-2 Gene and NF-<i>κ</i>B in Human Adenoid Cystic Carcinoma Tissue and Its Relation with Disease Prognosis" @default.
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- W4380077551 doi "https://doi.org/10.1166/jbt.2023.3267" @default.
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