FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380077891> ?p ?o ?g. }

• W4380077891 endingPage "376" @default.
• W4380077891 startingPage "371" @default.
• W4380077891 abstract "Background : Glial cell line derived neurotrophic factor (GDNF) is a potent neurotrophic factor, which has been shown to affect the metastasis and invasion of cancer cells. The molecular mechanism of GDNF is still unclear. Here, we investigate the mechanism of GDNF embedded in chitosan (CS) nano lipid carrier in colorectal cancer. Methods : Electron microscopy was used to detect the relationship between the characteristics of GDNF chitosan (CS) coated nano lipid carrier, MTT and apoptosis tests were used to detect the effect of GDNF chitosan nano lipid carrier expression on the proliferation ability of intestinal cancer cells, and immunofluorescence was used to detect the effect of GDNF chitosan nano lipid carrier expression on NF-KB signal. The results were verified by western-blot. In vivo using a mouse model. Results : GDNF chitosan nano lipid carrier showed positive zeta value, indicating that the process of CS coating GDNF was successful. OD values of nanocomposites at different concentrations were measured by UV spectrophotometer with MTT. Our data showed that the experimental group showed a relationship between concentration and dose dependent on tolerance growth, indicating that GDNF chitosan nano lipid carrier had better anti-tumor activity in colorectal cancer cell lines. Compared with most GDNF chitosan nano lipid carrier groups, the expression of NF- κ B immunofluorescence detection signal was inhibited, and the expression of NF- κ B was down-regulated in colorectal cancer. In vivo results showed that the measured tumor volume decreased after treatment with GDNF chitosan nanoparticle lipid carrier, and the survival of mice treated with GDNF chitosan nanoparticle lipid carrier was longer. Conclusion : GDNF chitosan nano lipid carrier can inhibit the expression of NF- κ B signal and reduce the proliferation of tumor In vivo , thus slowing down the occurrence and development of intestinal cancer cells." @default.
• W4380077891 created "2023-06-10" @default.
• W4380077891 creator A5004249429 @default.
• W4380077891 creator A5028535307 @default.
• W4380077891 creator A5058255461 @default.
• W4380077891 creator A5079163183 @default.
• W4380077891 date "2023-03-01" @default.
• W4380077891 modified "2023-09-23" @default.
• W4380077891 title "Glial Cell Line-Derived Neurotrophic Factor Chitosan Nanolipid Carrier Inhibits Intestinal Carcinoma via Restraining NF-<i>κ</i>B Activity" @default.
• W4380077891 cites W1836453327 @default.
• W4380077891 cites W1978186598 @default.
• W4380077891 cites W2001452983 @default.
• W4380077891 cites W2020398834 @default.
• W4380077891 cites W2032555915 @default.
• W4380077891 cites W2042276775 @default.
• W4380077891 cites W2064201629 @default.
• W4380077891 cites W2088631757 @default.
• W4380077891 cites W2104697096 @default.
• W4380077891 cites W2138194691 @default.
• W4380077891 cites W2288451153 @default.
• W4380077891 cites W2548959977 @default.
• W4380077891 cites W2753794629 @default.
• W4380077891 cites W2772903769 @default.
• W4380077891 cites W2791685494 @default.
• W4380077891 cites W2924473419 @default.
• W4380077891 cites W2947165337 @default.
• W4380077891 cites W2980794496 @default.
• W4380077891 cites W2983762161 @default.
• W4380077891 cites W3014229067 @default.
• W4380077891 cites W3039338730 @default.
• W4380077891 cites W3100302786 @default.
• W4380077891 cites W3186043979 @default.
• W4380077891 cites W3190107426 @default.
• W4380077891 doi "https://doi.org/10.1166/jbt.2023.3262" @default.
• W4380077891 hasPublicationYear "2023" @default.
• W4380077891 type Work @default.
• W4380077891 citedByCount "0" @default.
• W4380077891 crossrefType "journal-article" @default.
• W4380077891 hasAuthorship W4380077891A5004249429 @default.
• W4380077891 hasAuthorship W4380077891A5028535307 @default.
• W4380077891 hasAuthorship W4380077891A5058255461 @default.
• W4380077891 hasAuthorship W4380077891A5079163183 @default.
• W4380077891 hasConcept C150903083 @default.
• W4380077891 hasConcept C153911025 @default.
• W4380077891 hasConcept C160539049 @default.
• W4380077891 hasConcept C170493617 @default.
• W4380077891 hasConcept C185592680 @default.
• W4380077891 hasConcept C185856081 @default.
• W4380077891 hasConcept C190283241 @default.
• W4380077891 hasConcept C207001950 @default.
• W4380077891 hasConcept C2779732960 @default.
• W4380077891 hasConcept C2780783641 @default.
• W4380077891 hasConcept C502942594 @default.
• W4380077891 hasConcept C55493867 @default.
• W4380077891 hasConcept C71924100 @default.
• W4380077891 hasConcept C86803240 @default.
• W4380077891 hasConcept C94296188 @default.
• W4380077891 hasConceptScore W4380077891C150903083 @default.
• W4380077891 hasConceptScore W4380077891C153911025 @default.
• W4380077891 hasConceptScore W4380077891C160539049 @default.
• W4380077891 hasConceptScore W4380077891C170493617 @default.
• W4380077891 hasConceptScore W4380077891C185592680 @default.
• W4380077891 hasConceptScore W4380077891C185856081 @default.
• W4380077891 hasConceptScore W4380077891C190283241 @default.
• W4380077891 hasConceptScore W4380077891C207001950 @default.
• W4380077891 hasConceptScore W4380077891C2779732960 @default.
• W4380077891 hasConceptScore W4380077891C2780783641 @default.
• W4380077891 hasConceptScore W4380077891C502942594 @default.
• W4380077891 hasConceptScore W4380077891C55493867 @default.
• W4380077891 hasConceptScore W4380077891C71924100 @default.
• W4380077891 hasConceptScore W4380077891C86803240 @default.
• W4380077891 hasConceptScore W4380077891C94296188 @default.
• W4380077891 hasIssue "3" @default.
• W4380077891 hasLocation W43800778911 @default.
• W4380077891 hasOpenAccess W4380077891 @default.
• W4380077891 hasPrimaryLocation W43800778911 @default.
• W4380077891 hasRelatedWork W1965063755 @default.
• W4380077891 hasRelatedWork W2016898853 @default.
• W4380077891 hasRelatedWork W2020949259 @default.
• W4380077891 hasRelatedWork W2087262420 @default.
• W4380077891 hasRelatedWork W2153406820 @default.
• W4380077891 hasRelatedWork W2393156167 @default.
• W4380077891 hasRelatedWork W4313014309 @default.
• W4380077891 hasRelatedWork W4380077891 @default.
• W4380077891 hasRelatedWork W188453809 @default.
• W4380077891 hasRelatedWork W2523859916 @default.
• W4380077891 hasVolume "13" @default.
• W4380077891 isParatext "false" @default.
• W4380077891 isRetracted "false" @default.
• W4380077891 workType "article" @default.