FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380079329> ?p ?o ?g. }

• W4380079329 abstract "Abstract Ketamine’s role in providing a rapid and sustained antidepressant response, particularly for patients unresponsive to conventional treatments, is increasingly recognized. A core symptom of depression, anhedonia, or the loss of enjoyment or interest in previously pleasurable activities, is known to be significantly alleviated by ketamine. While several hypotheses have been proposed regarding the mechanisms by which ketamine alleviates anhedonia, the specific circuits and synaptic changes responsible for its sustained therapeutic effects are not yet understood. Here, we show that the nucleus accumbens (NAc), a major hub of the reward circuitry, is essential for ketamine’s effect in rescuing anhedonia in mice subjected to chronic stress, a critical risk factor in the genesis of depression in humans. Specifically, a single exposure to ketamine rescues stress-induced decreased strength of excitatory synapses on NAc D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs). By using a novel cell-specific pharmacology method, we demonstrate that this cell-type specific neuroadaptation is necessary for the sustained therapeutic effects of ketamine. To test for causal sufficiency, we artificially mimicked ketamine-induced increase in excitatory strength on D1-MSNs and found that this recapitulates the behavioral amelioration induced by ketamine. Finally, to determine the presynaptic origin of the relevant glutamatergic inputs for ketamine-elicited synaptic and behavioral effects, we used a combination of opto- and chemogenetics. We found that ketamine rescues stress-induced reduction in excitatory strength at medial prefrontal cortex and ventral hippocampus inputs to NAc D1-MSNs. Chemogenetically preventing ketamine-evoked plasticity at those unique inputs to the NAc reveals a ketamine-operated input-specific control of hedonic behavior. These results establish that ketamine rescues stress-induced anhedonia via cell-type-specific adaptations as well as information integration in the NAc via discrete excitatory synapses." @default.
• W4380079329 created "2023-06-10" @default.
• W4380079329 creator A5024040777 @default.
• W4380079329 creator A5044100508 @default.
• W4380079329 creator A5051855397 @default.
• W4380079329 creator A5060965341 @default.
• W4380079329 creator A5067163764 @default.
• W4380079329 creator A5078373067 @default.
• W4380079329 creator A5086133175 @default.
• W4380079329 creator A5089542294 @default.
• W4380079329 creator A5092127653 @default.
• W4380079329 date "2023-06-09" @default.
• W4380079329 modified "2023-09-25" @default.
• W4380079329 title "Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens" @default.
• W4380079329 cites W1867703876 @default.
• W4380079329 cites W1914381346 @default.
• W4380079329 cites W1981097208 @default.
• W4380079329 cites W1987349975 @default.
• W4380079329 cites W1991603311 @default.
• W4380079329 cites W1999772617 @default.
• W4380079329 cites W2005846380 @default.
• W4380079329 cites W2012129255 @default.
• W4380079329 cites W2018643157 @default.
• W4380079329 cites W2022082745 @default.
• W4380079329 cites W2022633426 @default.
• W4380079329 cites W2023081218 @default.
• W4380079329 cites W2028980996 @default.
• W4380079329 cites W2032739515 @default.
• W4380079329 cites W2050639539 @default.
• W4380079329 cites W2063744578 @default.
• W4380079329 cites W2070712548 @default.
• W4380079329 cites W2087002084 @default.
• W4380079329 cites W2089351762 @default.
• W4380079329 cites W2100036649 @default.
• W4380079329 cites W2101540672 @default.
• W4380079329 cites W2109334244 @default.
• W4380079329 cites W2123916840 @default.
• W4380079329 cites W2127114472 @default.
• W4380079329 cites W2129579709 @default.
• W4380079329 cites W2139358036 @default.
• W4380079329 cites W2149402043 @default.
• W4380079329 cites W2161321963 @default.
• W4380079329 cites W2346390990 @default.
• W4380079329 cites W2517085860 @default.
• W4380079329 cites W2520064463 @default.
• W4380079329 cites W2604969293 @default.
• W4380079329 cites W2755167598 @default.
• W4380079329 cites W2785770559 @default.
• W4380079329 cites W2787343838 @default.
• W4380079329 cites W2794251999 @default.
• W4380079329 cites W2796615944 @default.
• W4380079329 cites W2900803145 @default.
• W4380079329 cites W2907221662 @default.
• W4380079329 cites W2913064755 @default.
• W4380079329 cites W2921561928 @default.
• W4380079329 cites W2933289315 @default.
• W4380079329 cites W2935995671 @default.
• W4380079329 cites W2943954810 @default.
• W4380079329 cites W2952426443 @default.
• W4380079329 cites W2978956383 @default.
• W4380079329 cites W3010809239 @default.
• W4380079329 cites W3043985951 @default.
• W4380079329 cites W3045916251 @default.
• W4380079329 cites W3086459126 @default.
• W4380079329 cites W3126592836 @default.
• W4380079329 cites W3170387099 @default.
• W4380079329 cites W4200200347 @default.
• W4380079329 cites W4211263234 @default.
• W4380079329 cites W4220922409 @default.
• W4380079329 cites W4231169313 @default.
• W4380079329 cites W4307448381 @default.
• W4380079329 cites W4323826024 @default.
• W4380079329 cites W854901204 @default.
• W4380079329 doi "https://doi.org/10.1101/2023.06.08.544088" @default.
• W4380079329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37333325" @default.
• W4380079329 hasPublicationYear "2023" @default.
• W4380079329 type Work @default.
• W4380079329 citedByCount "0" @default.
• W4380079329 crossrefType "posted-content" @default.
• W4380079329 hasAuthorship W4380079329A5024040777 @default.
• W4380079329 hasAuthorship W4380079329A5044100508 @default.
• W4380079329 hasAuthorship W4380079329A5051855397 @default.
• W4380079329 hasAuthorship W4380079329A5060965341 @default.
• W4380079329 hasAuthorship W4380079329A5067163764 @default.
• W4380079329 hasAuthorship W4380079329A5078373067 @default.
• W4380079329 hasAuthorship W4380079329A5086133175 @default.
• W4380079329 hasAuthorship W4380079329A5089542294 @default.
• W4380079329 hasAuthorship W4380079329A5092127653 @default.
• W4380079329 hasBestOaLocation W43800793291 @default.
• W4380079329 hasConcept C112592302 @default.
• W4380079329 hasConcept C126322002 @default.
• W4380079329 hasConcept C15744967 @default.
• W4380079329 hasConcept C169760540 @default.
• W4380079329 hasConcept C170493617 @default.
• W4380079329 hasConcept C17077164 @default.
• W4380079329 hasConcept C2776552330 @default.
• W4380079329 hasConcept C2778941446 @default.
• W4380079329 hasConcept C2779177272 @default.
• W4380079329 hasConcept C2780648746 @default.
• W4380079329 hasConcept C2780795376 @default.

• next