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- W4380079596 endingPage "966" @default.
- W4380079596 startingPage "966" @default.
- W4380079596 abstract "Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies. We propose to refer to all diseases whose pathogenesis or progression is associated with cellular senescence as senopathies. Targeting senescent cells with senolytics or senomorphics is likely to mitigate these pathologies. Examples of senopathies include cardiovascular, metabolic, musculoskeletal, liver, kidney, and lung diseases and neurodegeneration. For all these pathologies, animal studies provide clear mechanistic evidence for a connection between senescent cell accumulation and disease progression. The major persisting challenge in developing novel senotherapies is the heterogeneity of senescence phenotypes, causing a lack of universal biomarkers and difficulties in discriminating senescent from non-senescent cells." @default.
- W4380079596 created "2023-06-10" @default.
- W4380079596 creator A5001127964 @default.
- W4380079596 creator A5037707282 @default.
- W4380079596 creator A5068178323 @default.
- W4380079596 date "2023-06-08" @default.
- W4380079596 modified "2023-09-28" @default.
- W4380079596 title "Senopathies—Diseases Associated with Cellular Senescence" @default.
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- W4380079596 doi "https://doi.org/10.3390/biom13060966" @default.
- W4380079596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37371545" @default.
- W4380079596 hasPublicationYear "2023" @default.
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