Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380080036> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4380080036 endingPage "488" @default.
- W4380080036 startingPage "483" @default.
- W4380080036 abstract "MICA and MICB are non-classical MHC molecules that indicate cellular stress. They act as ligands for NKG2D receptors found on NK cells, thereby triggering a cytotoxic response against damaged, infected, or transformed cells. The production of soluble forms of MICA/MICB occurs via the cleavage of their extracellular domains (ECDs). The expression of MICA/MICB molecules in tumor sections or the levels of their soluble forms in blood have potential as diagnostic tools for cancer. They can predict important clinical outcomes for cancer patients, such as overall and recurrence-free survival. However, their extensive molecular polymorphism complicates the development of monoclonal antibodies (mAbs) for diagnostic use. Therefore, the diagnostic value of mAb-based assays may vary depending on the frequencies of allelic variants in local human populations. We examined the ECD amino acid sequences of more than 280 MICA and 50 MICB allelic variants. Additionally, we identified 172 and 58 single nucleotide polymorphisms (SNPs) located in the coding regions of the respective genes and resulting in amino acid replacements. The most frequent amino acid replacements (> 10%) in the ECD occur at 11 and 4 sites of MICA and MICB, respectively. We found that the frequencies of SNPs in the identified hot spots strongly correlate with each other in different human populations, despite the diversity of allelic variant frequencies. The functional role of only one site is known. The replacement of valine with methionine at position 152 enhances the affinity of MICA to NKG2D receptor. As the hot spots are dispersed throughout the entire ECD sequences, they may play a role other than modulating affinity with the NKG2D receptor interaction. We recommend that Ag sets used to validate anti-MICA/MICB mAbs meet two criteria. First, they should include both MICA and MICB alleles, as these genes have highly similar sequences. Second, the alleles should cover the variability observed in the identified hot spots." @default.
- W4380080036 created "2023-06-10" @default.
- W4380080036 creator A5026248779 @default.
- W4380080036 creator A5058732694 @default.
- W4380080036 date "2023-06-01" @default.
- W4380080036 modified "2023-09-27" @default.
- W4380080036 title "Mutation hot spots in MICA/MICB extracellular domains" @default.
- W4380080036 cites W1926547880 @default.
- W4380080036 cites W1963753552 @default.
- W4380080036 cites W1982780404 @default.
- W4380080036 cites W2053127535 @default.
- W4380080036 cites W2053505816 @default.
- W4380080036 cites W2058707044 @default.
- W4380080036 cites W2082450253 @default.
- W4380080036 cites W2111052299 @default.
- W4380080036 cites W2147455946 @default.
- W4380080036 cites W2794808923 @default.
- W4380080036 cites W2802986564 @default.
- W4380080036 cites W2808321351 @default.
- W4380080036 cites W2948850940 @default.
- W4380080036 cites W3006827712 @default.
- W4380080036 doi "https://doi.org/10.15789/1563-0625-mhs-2680" @default.
- W4380080036 hasPublicationYear "2023" @default.
- W4380080036 type Work @default.
- W4380080036 citedByCount "0" @default.
- W4380080036 crossrefType "journal-article" @default.
- W4380080036 hasAuthorship W4380080036A5026248779 @default.
- W4380080036 hasAuthorship W4380080036A5058732694 @default.
- W4380080036 hasBestOaLocation W43800800361 @default.
- W4380080036 hasConcept C104317684 @default.
- W4380080036 hasConcept C135763542 @default.
- W4380080036 hasConcept C153209595 @default.
- W4380080036 hasConcept C153911025 @default.
- W4380080036 hasConcept C154317977 @default.
- W4380080036 hasConcept C170627219 @default.
- W4380080036 hasConcept C202751555 @default.
- W4380080036 hasConcept C207936829 @default.
- W4380080036 hasConcept C2778867473 @default.
- W4380080036 hasConcept C515207424 @default.
- W4380080036 hasConcept C54355233 @default.
- W4380080036 hasConcept C86803240 @default.
- W4380080036 hasConceptScore W4380080036C104317684 @default.
- W4380080036 hasConceptScore W4380080036C135763542 @default.
- W4380080036 hasConceptScore W4380080036C153209595 @default.
- W4380080036 hasConceptScore W4380080036C153911025 @default.
- W4380080036 hasConceptScore W4380080036C154317977 @default.
- W4380080036 hasConceptScore W4380080036C170627219 @default.
- W4380080036 hasConceptScore W4380080036C202751555 @default.
- W4380080036 hasConceptScore W4380080036C207936829 @default.
- W4380080036 hasConceptScore W4380080036C2778867473 @default.
- W4380080036 hasConceptScore W4380080036C515207424 @default.
- W4380080036 hasConceptScore W4380080036C54355233 @default.
- W4380080036 hasConceptScore W4380080036C86803240 @default.
- W4380080036 hasIssue "3" @default.
- W4380080036 hasLocation W43800800361 @default.
- W4380080036 hasOpenAccess W4380080036 @default.
- W4380080036 hasPrimaryLocation W43800800361 @default.
- W4380080036 hasRelatedWork W2001538452 @default.
- W4380080036 hasRelatedWork W2004902129 @default.
- W4380080036 hasRelatedWork W2030437891 @default.
- W4380080036 hasRelatedWork W2030677697 @default.
- W4380080036 hasRelatedWork W2032883351 @default.
- W4380080036 hasRelatedWork W2037773889 @default.
- W4380080036 hasRelatedWork W2045757315 @default.
- W4380080036 hasRelatedWork W2050232608 @default.
- W4380080036 hasRelatedWork W2082607788 @default.
- W4380080036 hasRelatedWork W2084863090 @default.
- W4380080036 hasVolume "25" @default.
- W4380080036 isParatext "false" @default.
- W4380080036 isRetracted "false" @default.
- W4380080036 workType "article" @default.