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• W4380080082 endingPage "5858" @default.
• W4380080082 startingPage "5850" @default.
• W4380080082 abstract "Biological nanopore sensors are widely used for genetic sequencing as nucleic acids and other molecules translocate through them across membranes. Recent studies have shown that the transport of these polymers through nanopores is strongly influenced by macromolecular bulk crowders. By using poly(ethylene glycol) (PEG) molecules as crowders, experiments have shown an increase in the capture rates and translocation times of polymers through an α-hemolysin (αHL) nanopore, which provides high-throughput signals and accurate sensing. A clear molecular-level understanding of how the presence of PEGs offers such desirable outcomes in nanopore sensing is still missing. In this work, we present a new theoretical approach to probe the effect of PEG crowders on DNA capture and translocation through the αHL nanopore. We develop an exactly solvable discrete-state stochastic model based on the cooperative partitioning of individual polycationic PEGs within the cavity of the αHL nanopore. It is argued that the apparent electrostatic interactions between the DNA and PEGs control all of the dynamic processes. Our analytical predictions find excellent agreements with existing experiments, thereby strongly supporting our theory." @default.
• W4380080082 created "2023-06-10" @default.
• W4380080082 creator A5017989984 @default.
• W4380080082 creator A5063345426 @default.
• W4380080082 date "2023-06-09" @default.
• W4380080082 modified "2023-09-27" @default.
• W4380080082 title "Microscopic Mechanism of Macromolecular Crowder-Assisted DNA Capture and Translocation through Biological Nanopores" @default.
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• W4380080082 doi "https://doi.org/10.1021/acs.jpcb.3c02792" @default.
• W4380080082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37294938" @default.
• W4380080082 hasPublicationYear "2023" @default.
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