FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380080238> ?p ?o ?g. }

• W4380080238 abstract "Abstract Background Treatment of pediatric cataract remains challenging because of the extremely high incidence of postoperative adverse events (AEs), especially the AEs related to the locations of secondary implanted intraocular lens (IOL). There are two common locations for secondary IOL implantation in pediatric aphakic eyes: ciliary sulcus or in-the-bag implantation. However, there are currently no large, prospective studies comparing complication rates and visual prognosis of in-the-bag versus ciliarysulcus secondary IOL implantation in pediatric patients. Whether or how much secondary in-the-bag IOL implantation benefits the pediatric patients more than sulcus implantation and deserves to be performed routinely by surgeons remains to be elucidated. Here, we describe the protocol of a randomized controlled trial (RCT) designed to evaluate the safety and efficacy of two approaches of IOL implantation in pediatric aphakia. Methods The study is a multicenter, single-blinded RCT with 10 years of follow-up. Overall, a minimum of 286 eyes (approximately 228 participants assuming 75% have two study eyes) will be recruited. This study will be carried out in four eye clinics across China. Consecutive eligible patients are randomized to undergo either secondary in-the-bag IOL implantation or secondary sulcus IOL implantation. Participants with two eyes eligible will receive the same treatment. The primary outcomes are IOL decentration and the incidence of glaucoma-related AEs. The secondary outcomes include the incidence of other AEs, IOL tilt, visual acuity, and ocular refractive power. Analysis of the primary and secondary outcomes is to be based on the intention-to-treat and per-protocol analysis. Statistical analyses will include the χ 2 test or Fisher’s exact test for the primary outcome, mixed model and generalized estimated equation (GEE) model for the secondary outcome, Kaplan–Meier survival curves for the cumulative probability of glaucoma-related AEs over time in each group. Discussion To the best of our knowledge, this study is the first RCT to evaluate the safety and efficacy of secondary IOL implantation in pediatric aphakia. The results will provide high-quality evidence for the clinical guidelines for the treatment of pediatric aphakia. Trial registration ClinicalTrials.gov NCT05136950. Registered on 1 November 2021." @default.
• W4380080238 created "2023-06-10" @default.
• W4380080238 creator A5003912075 @default.
• W4380080238 creator A5009865463 @default.
• W4380080238 creator A5023108032 @default.
• W4380080238 creator A5034263995 @default.
• W4380080238 creator A5041718092 @default.
• W4380080238 creator A5044796157 @default.
• W4380080238 creator A5045581422 @default.
• W4380080238 creator A5067362161 @default.
• W4380080238 creator A5091288900 @default.
• W4380080238 date "2023-06-09" @default.
• W4380080238 modified "2023-09-25" @default.
• W4380080238 title "Safety and efficacy in pediatric secondary intraocular lens implantation, in-the-bag versus sulcus implantation: a multicenter, single-blinded randomized controlled trial" @default.
• W4380080238 cites W1991877091 @default.
• W4380080238 cites W2011192712 @default.
• W4380080238 cites W2019250174 @default.
• W4380080238 cites W2037624849 @default.
• W4380080238 cites W2052668709 @default.
• W4380080238 cites W2055644009 @default.
• W4380080238 cites W2062249590 @default.
• W4380080238 cites W2076316381 @default.
• W4380080238 cites W2093589272 @default.
• W4380080238 cites W2105911353 @default.
• W4380080238 cites W2107136865 @default.
• W4380080238 cites W2149095874 @default.
• W4380080238 cites W2166023752 @default.
• W4380080238 cites W2414219365 @default.
• W4380080238 cites W2471169743 @default.
• W4380080238 cites W2585164630 @default.
• W4380080238 cites W2889157550 @default.
• W4380080238 cites W2899227110 @default.
• W4380080238 cites W2984817926 @default.
• W4380080238 cites W2987357514 @default.
• W4380080238 cites W2990041012 @default.
• W4380080238 cites W3008303167 @default.
• W4380080238 cites W3207977656 @default.
• W4380080238 doi "https://doi.org/10.1186/s13063-023-07411-z" @default.
• W4380080238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37296411" @default.
• W4380080238 hasPublicationYear "2023" @default.
• W4380080238 type Work @default.
• W4380080238 citedByCount "0" @default.
• W4380080238 crossrefType "journal-article" @default.
• W4380080238 hasAuthorship W4380080238A5003912075 @default.
• W4380080238 hasAuthorship W4380080238A5009865463 @default.
• W4380080238 hasAuthorship W4380080238A5023108032 @default.
• W4380080238 hasAuthorship W4380080238A5034263995 @default.
• W4380080238 hasAuthorship W4380080238A5041718092 @default.
• W4380080238 hasAuthorship W4380080238A5044796157 @default.
• W4380080238 hasAuthorship W4380080238A5045581422 @default.
• W4380080238 hasAuthorship W4380080238A5067362161 @default.
• W4380080238 hasAuthorship W4380080238A5091288900 @default.
• W4380080238 hasBestOaLocation W43800802381 @default.
• W4380080238 hasConcept C118487528 @default.
• W4380080238 hasConcept C120665830 @default.
• W4380080238 hasConcept C121332964 @default.
• W4380080238 hasConcept C126322002 @default.
• W4380080238 hasConcept C141071460 @default.
• W4380080238 hasConcept C168563851 @default.
• W4380080238 hasConcept C2777345934 @default.
• W4380080238 hasConcept C2778257484 @default.
• W4380080238 hasConcept C2779567214 @default.
• W4380080238 hasConcept C535046627 @default.
• W4380080238 hasConcept C61511704 @default.
• W4380080238 hasConcept C71924100 @default.
• W4380080238 hasConceptScore W4380080238C118487528 @default.
• W4380080238 hasConceptScore W4380080238C120665830 @default.
• W4380080238 hasConceptScore W4380080238C121332964 @default.
• W4380080238 hasConceptScore W4380080238C126322002 @default.
• W4380080238 hasConceptScore W4380080238C141071460 @default.
• W4380080238 hasConceptScore W4380080238C168563851 @default.
• W4380080238 hasConceptScore W4380080238C2777345934 @default.
• W4380080238 hasConceptScore W4380080238C2778257484 @default.
• W4380080238 hasConceptScore W4380080238C2779567214 @default.
• W4380080238 hasConceptScore W4380080238C535046627 @default.
• W4380080238 hasConceptScore W4380080238C61511704 @default.
• W4380080238 hasConceptScore W4380080238C71924100 @default.
• W4380080238 hasIssue "1" @default.
• W4380080238 hasLocation W43800802381 @default.
• W4380080238 hasLocation W43800802382 @default.
• W4380080238 hasOpenAccess W4380080238 @default.
• W4380080238 hasPrimaryLocation W43800802381 @default.
• W4380080238 hasRelatedWork W1989410790 @default.
• W4380080238 hasRelatedWork W1989648343 @default.
• W4380080238 hasRelatedWork W2039687413 @default.
• W4380080238 hasRelatedWork W2046917830 @default.
• W4380080238 hasRelatedWork W2108602187 @default.
• W4380080238 hasRelatedWork W2170135666 @default.
• W4380080238 hasRelatedWork W2384954434 @default.
• W4380080238 hasRelatedWork W2546896405 @default.
• W4380080238 hasRelatedWork W3174787045 @default.
• W4380080238 hasRelatedWork W3023924543 @default.
• W4380080238 hasVolume "24" @default.
• W4380080238 isParatext "false" @default.
• W4380080238 isRetracted "false" @default.
• W4380080238 workType "article" @default.