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- W4380080596 abstract "Background: The role of N6-methyladenosine (m6A) modification in tumor microenvironment has rarely been explored in follicular lymphoma (FL). Methods: To examine the role of m6A modification in biological behavior, especially the immune landscape of FL, we utilized the Gene Expression Omnibus database to determine the expression signatures of m6A-regulators by unsupervised clustering, and then condense into a risk score, which was validated in an external cohort from the Tianjin Medical University Cancer Institute and Hospital. Results: 16 m6A-regulators in 351 FL patients were evaluated and two m6A clusters were identified, characterized by differences in prognosis and biological behaviors. The m6A score was further developed based on 20-genes to quantify the m6A-regulator expression signature in each patient with FL. The low m6A score was associated with inferior prognosis of patients, with a median survival time of 8.84 (95% confidence interval [CI]: 7.251–10.429) years, which was remarkably shorter than that of patients with high m6A scores (15.73 years, 95% CI: 11.729–19.731; p < 0.0001). Genes like TNFRSF14, CREBBP, and CARD11 were shown to be more often mutated in the low m6A group. This group was enriched with immune/inflammatory response but along with the abundant infiltration of exhausted T cells and the upregulated PD-1 and PD-L1 expression. Finally, we verified the m6A score could predict the response to anti-PD-L1 antibodies in an immunotherapy cohort. Conclusions: To conclude, the m6A score recognizes a section of FL patients harboring an exhausted tumor microenvironment and may help guide more effective immunotherapy strategies for patients with FL. Keywords: bioinformatics, computational and systems biology, indolent non-Hodgkin lymphoma No conflicts of interests pertinent to the abstract." @default.
- W4380080596 created "2023-06-10" @default.
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- W4380080596 date "2023-06-01" @default.
- W4380080596 modified "2023-10-12" @default.
- W4380080596 title "M6A‐REGULATOR EXPRESSION SIGNATURES IDENTIFY A SUBSET OF FOLLICULAR LYMPHOMA HARBORING AN EXHAUSTED TUMOR MICROENVIRONMENT" @default.
- W4380080596 doi "https://doi.org/10.1002/hon.3165_480" @default.
- W4380080596 hasPublicationYear "2023" @default.
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