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- W4380081110 endingPage "1360" @default.
- W4380081110 startingPage "1360" @default.
- W4380081110 abstract "A pangenome is a collection of the common and unique genomes that are present in a given species. It combines the genetic information of all the genomes sampled, resulting in a large and diverse range of genetic material. Pangenomic analysis offers several advantages compared to traditional genomic research. For example, a pangenome is not bound by the physical constraints of a single genome, so it can capture more genetic variability. Thanks to the introduction of the concept of pangenome, it is possible to use exceedingly detailed sequence data to study the evolutionary history of two different species, or how populations within a species differ genetically. In the wake of the Human Pangenome Project, this review aims at discussing the advantages of the pangenome around human genetic variation, which are then framed around how pangenomic data can inform population genetics, phylogenetics, and public health policy by providing insights into the genetic basis of diseases or determining personalized treatments, targeting the specific genetic profile of an individual. Moreover, technical limitations, ethical concerns, and legal considerations are discussed." @default.
- W4380081110 created "2023-06-10" @default.
- W4380081110 creator A5012406384 @default.
- W4380081110 creator A5022124738 @default.
- W4380081110 creator A5040152187 @default.
- W4380081110 date "2023-06-09" @default.
- W4380081110 modified "2023-10-18" @default.
- W4380081110 title "Human Pangenomics: Promises and Challenges of a Distributed Genomic Reference" @default.
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