Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380081917> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4380081917 abstract "<div>Abstract<p>The development of novel therapies for brain metastases is an unmet need. Brain metastases may have unique molecular features that could be explored as therapeutic targets. A better understanding of the drug sensitivity of live cells coupled to molecular analyses will lead to a rational prioritization of therapeutic candidates. We evaluated the molecular profiles of twelve breast cancer brain metastases (BCBM) and matched primary breast tumors to identify potential therapeutic targets. We established six novel patient-derived xenograft (PDX) from BCBM from patients undergoing clinically indicated surgical resection of BCBM and used the PDXs as a drug screening platform to interrogate potential molecular targets. Many of the alterations were conserved in brain metastases compared to the matched primary. We observed differential expressions in the immune-related and metabolism pathways. The PDXs from BCBM captured the potentially targetable molecular alterations in the source brain metastases tumor. The alterations in the PI3K pathway were the most predictive for drug efficacy in the PDXs. The PDXs were also treated with a panel of over 350 drugs and demonstrated high sensitivity to HDAC and proteasome inhibitors. Our study revealed significant differences between the paired BCBM and primary breast tumors with the pathways involved in metabolisms and immune functions. While molecular-targeted drug therapy based on genomic profiling of tumors is currently evaluated in clinical trials for patients with brain metastases, a functional precision medicine strategy may complement such an approach by expanding potential therapeutic options, even for BCBM without known targetable molecular alterations.</p></div>" @default.
- W4380081917 created "2023-06-10" @default.
- W4380081917 creator A5003311852 @default.
- W4380081917 creator A5014889955 @default.
- W4380081917 creator A5022715364 @default.
- W4380081917 creator A5024470416 @default.
- W4380081917 creator A5026294772 @default.
- W4380081917 creator A5030234836 @default.
- W4380081917 creator A5040747167 @default.
- W4380081917 creator A5051217140 @default.
- W4380081917 creator A5052914934 @default.
- W4380081917 creator A5063344282 @default.
- W4380081917 creator A5066417295 @default.
- W4380081917 creator A5069748055 @default.
- W4380081917 creator A5071608210 @default.
- W4380081917 creator A5075441749 @default.
- W4380081917 creator A5077292948 @default.
- W4380081917 creator A5083834388 @default.
- W4380081917 creator A5085296426 @default.
- W4380081917 creator A5088860440 @default.
- W4380081917 creator A5091212288 @default.
- W4380081917 date "2023-06-09" @default.
- W4380081917 modified "2023-09-22" @default.
- W4380081917 title "Data from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment." @default.
- W4380081917 doi "https://doi.org/10.1158/2767-9764.c.6689056.v1" @default.
- W4380081917 hasPublicationYear "2023" @default.
- W4380081917 type Work @default.
- W4380081917 citedByCount "0" @default.
- W4380081917 crossrefType "posted-content" @default.
- W4380081917 hasAuthorship W4380081917A5003311852 @default.
- W4380081917 hasAuthorship W4380081917A5014889955 @default.
- W4380081917 hasAuthorship W4380081917A5022715364 @default.
- W4380081917 hasAuthorship W4380081917A5024470416 @default.
- W4380081917 hasAuthorship W4380081917A5026294772 @default.
- W4380081917 hasAuthorship W4380081917A5030234836 @default.
- W4380081917 hasAuthorship W4380081917A5040747167 @default.
- W4380081917 hasAuthorship W4380081917A5051217140 @default.
- W4380081917 hasAuthorship W4380081917A5052914934 @default.
- W4380081917 hasAuthorship W4380081917A5063344282 @default.
- W4380081917 hasAuthorship W4380081917A5066417295 @default.
- W4380081917 hasAuthorship W4380081917A5069748055 @default.
- W4380081917 hasAuthorship W4380081917A5071608210 @default.
- W4380081917 hasAuthorship W4380081917A5075441749 @default.
- W4380081917 hasAuthorship W4380081917A5077292948 @default.
- W4380081917 hasAuthorship W4380081917A5083834388 @default.
- W4380081917 hasAuthorship W4380081917A5085296426 @default.
- W4380081917 hasAuthorship W4380081917A5088860440 @default.
- W4380081917 hasAuthorship W4380081917A5091212288 @default.
- W4380081917 hasConcept C121608353 @default.
- W4380081917 hasConcept C126322002 @default.
- W4380081917 hasConcept C142724271 @default.
- W4380081917 hasConcept C143998085 @default.
- W4380081917 hasConcept C163763905 @default.
- W4380081917 hasConcept C2779130545 @default.
- W4380081917 hasConcept C2780035454 @default.
- W4380081917 hasConcept C502942594 @default.
- W4380081917 hasConcept C530470458 @default.
- W4380081917 hasConcept C60644358 @default.
- W4380081917 hasConcept C64903051 @default.
- W4380081917 hasConcept C71924100 @default.
- W4380081917 hasConcept C86803240 @default.
- W4380081917 hasConcept C98274493 @default.
- W4380081917 hasConceptScore W4380081917C121608353 @default.
- W4380081917 hasConceptScore W4380081917C126322002 @default.
- W4380081917 hasConceptScore W4380081917C142724271 @default.
- W4380081917 hasConceptScore W4380081917C143998085 @default.
- W4380081917 hasConceptScore W4380081917C163763905 @default.
- W4380081917 hasConceptScore W4380081917C2779130545 @default.
- W4380081917 hasConceptScore W4380081917C2780035454 @default.
- W4380081917 hasConceptScore W4380081917C502942594 @default.
- W4380081917 hasConceptScore W4380081917C530470458 @default.
- W4380081917 hasConceptScore W4380081917C60644358 @default.
- W4380081917 hasConceptScore W4380081917C64903051 @default.
- W4380081917 hasConceptScore W4380081917C71924100 @default.
- W4380081917 hasConceptScore W4380081917C86803240 @default.
- W4380081917 hasConceptScore W4380081917C98274493 @default.
- W4380081917 hasLocation W43800819171 @default.
- W4380081917 hasOpenAccess W4380081917 @default.
- W4380081917 hasPrimaryLocation W43800819171 @default.
- W4380081917 hasRelatedWork W1984009717 @default.
- W4380081917 hasRelatedWork W2085367843 @default.
- W4380081917 hasRelatedWork W2113072832 @default.
- W4380081917 hasRelatedWork W2160992314 @default.
- W4380081917 hasRelatedWork W2224319365 @default.
- W4380081917 hasRelatedWork W2402123026 @default.
- W4380081917 hasRelatedWork W2535082381 @default.
- W4380081917 hasRelatedWork W2952257831 @default.
- W4380081917 hasRelatedWork W377899687 @default.
- W4380081917 hasRelatedWork W4291016733 @default.
- W4380081917 isParatext "false" @default.
- W4380081917 isRetracted "false" @default.
- W4380081917 workType "article" @default.