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• W4380082608 startingPage "1284" @default.
• W4380082608 abstract "Human infections caused by Candida albicans are common and range in severity from relatively treatable skin and mucosal conditions to systemic, fatal invasive candidiasis. The treatment of fungal infections is challenged by major obstacles, including the scarcity of effective therapeutic options, the toxicity of available medications, and the escalating antifungal resistance. Hence, there exists an urgent need to develop new classes of antimicrobial agents. This study was conducted to investigate the effect of KW-23 peptide against standard and resistant strains of C. albicans alone and in combination with fluconazole.A conjugated ultrashort antimicrobial peptide (KW-23) was designed and synthesized. KW-23 was challenged against standard and multidrug-resistant C. albicans alone and in combination with fluconazole using standard antimicrobial and checkerboard assays. The toxicity of the peptide was examined using hemolytic assays.KW-23 positively affected the standard and resistant Candidal strains (at 5 and 15 μg/mL respectively), exhibiting potent synergistic antimicrobial activity against the standard strain when combined with fluconazole. The effect of the combination was additive against the resistant strain (0.6 μg/mL). Furthermore, the peptide exhibited negligible toxicity on human erythrocytes.KW-23 and its combination with fluconazole could be a promising candidate for developing anticandidal agents." @default.
• W4380082608 created "2023-06-10" @default.
• W4380082608 creator A5005622789 @default.
• W4380082608 creator A5058849766 @default.
• W4380082608 date "2023-06-01" @default.
• W4380082608 modified "2023-09-27" @default.
• W4380082608 title "A pilot study on ultrashort peptide with fluconazole: A promising novel anticandidal combination" @default.
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• W4380082608 doi "https://doi.org/10.14202/vetworld.2023.1284-1288" @default.
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