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• W4380086080 abstract "Emerging evidence shows that pyroptosis plays a crucial role in the development and progression of multiple types of cancer. However, there is a limited understanding of the role of pyroptosis in DLBCL. The study aimed to identify pyroptosis-related signatures, develop a novel prognostic model, and investigate immune infiltration profiles in DLBCL. The expression profiles of pyroptosis-related genes (PRGs) in DLBCL and normal samples were examined, and the clinical characteristics of DLBCL patients. LASSO Cox regression analyses were performed to develop a prognostic model based on six PRGs. The expression of differentially expressed PRGs in DLBCL cell lines was validated using qRT-PCR. To explore the expression profile characteristics of PRGs in DLBCL, the mRNA expression levels of PRGs were evaluated in DLBCL and normal samples. The results revealed that the majority of PRGs were dysregulated in DLBCL samples. The clinical significance of PRGs in DLBCL was further evaluated. 19 genes were significantly associated with OS of DLBCL patients in the univariate Cox regression. Six PRGs were selected for the risk model according to the minimum criteria of the LASSO Cox regression, and DLBCL patients were divided into groups of high and low. The low-risk group exhibited lower mortality rates and longer OS than the high-risk group (Figure 1A). Significantly shorter OS was observed in DLBCL patients with high risks (Figure 1B). To further verify the expression levels of PRGs in DLBCL, we assessed the mRNA expression levels of the above six PRGs by qRT-PCR in DLBCL cell lines. Compared with normal samples, CASP8, CASP9, NLRP1, NLRP6, and TIRAP were significantly down-regulated in DLBCL cell lines, while SCAF11 was significantly up-regulated. These results revealed the outstanding predictive efficacy and superiority of this model. The potential biological role and the mechanism of PRGs causing different risks were further explored. GO and KEGG enrichment illuminated that these PRGs may be involved in cellular protein modification processes and regulation of JAK-STAT signaling pathway. Given the strongly correlation with tumor immune environment, we analyzed the immune status of different risk groups. The low-risk group showed higher activity immune infiltration and immune checkpoint pathways than the high-risk group. We found that the risk scores corresponded with the immune profile, and the elevated immune activity might contribute to the antitumor effect of DLBCL. Keywords: aggressive B-cell non-Hodgkin lymphoma, diagnostic and prognostic biomarkers No conflicts of interests pertinent to the abstract." @default.
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• W4380086080 date "2023-06-01" @default.
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• W4380086080 title "IDENTIFYING A NOVEL DEFINED PYROPTOSIS‐ASSOCIATED SIGNATURE CONTRIBUTES TO PREDICTING PROGNOSIS AND TUMOR MICROENVIRONMENT OF DIFFUSE LARGE B‐CELL LYMPHOMA" @default.
• W4380086080 doi "https://doi.org/10.1002/hon.3165_486" @default.
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