FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380090350> ?p ?o ?g. }

• W4380090350 endingPage "104906" @default.
• W4380090350 startingPage "104906" @default.
• W4380090350 abstract "The tumor suppressor Liver Kinase B1 (LKB1) is a multifunctional serine/threonine protein kinase that regulates cell metabolism, polarity, and growth and is associated with Peutz-Jeghers Syndrome and cancer predisposition. The LKB1 gene comprises 10 exons and 9 introns. Three spliced LKB1 variants have been documented, and they reside mainly in the cytoplasm, although two possess a nuclear-localization sequence (NLS) and are able to shuttle into the nucleus. Here, we report the identification of a fourth and novel LKB1 isoform that is, interestingly, targeted to the mitochondria. We show that this mitochondria-localized LKB1 (mLKB1) is generated from alternative splicing in the 5' region of the transcript and translated from an alternative initiation codon encoded by a previously unknown exon 1b (131 bp) hidden within the long intron 1 of LKB1 gene. We found by replacing the N-terminal NLS of the canonical LKB1 isoform, the N-terminus of the alternatively spliced mLKB1 variant encodes a mitochondrial transit peptide that allows it to localize to the mitochondria. We further demonstrate that mLKB1 colocalizes histologically with mitochondria-resident ATP Synthase and NAD-dependent deacetylase sirtuin-3, mitochondrial (SIRT3) and that its expression is rapidly and transiently upregulated by oxidative stress. We conclude that this novel LKB1 isoform, mLKB1, plays a critical role in regulating mitochondrial metabolic activity and oxidative stress response." @default.
• W4380090350 created "2023-06-10" @default.
• W4380090350 creator A5001079874 @default.
• W4380090350 creator A5005526622 @default.
• W4380090350 creator A5024592486 @default.
• W4380090350 creator A5045750845 @default.
• W4380090350 creator A5047677716 @default.
• W4380090350 creator A5079114350 @default.
• W4380090350 date "2023-07-01" @default.
• W4380090350 modified "2023-10-04" @default.
• W4380090350 title "Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response" @default.
• W4380090350 cites W1619256199 @default.
• W4380090350 cites W1967645880 @default.
• W4380090350 cites W1972899801 @default.
• W4380090350 cites W1975646933 @default.
• W4380090350 cites W1976760923 @default.
• W4380090350 cites W1987313243 @default.
• W4380090350 cites W1989128549 @default.
• W4380090350 cites W1989710643 @default.
• W4380090350 cites W1991982395 @default.
• W4380090350 cites W1994154030 @default.
• W4380090350 cites W2000859778 @default.
• W4380090350 cites W2005912928 @default.
• W4380090350 cites W2006659499 @default.
• W4380090350 cites W2033406275 @default.
• W4380090350 cites W2044874695 @default.
• W4380090350 cites W2048573827 @default.
• W4380090350 cites W2052498320 @default.
• W4380090350 cites W2053134659 @default.
• W4380090350 cites W2059825898 @default.
• W4380090350 cites W2065260669 @default.
• W4380090350 cites W2067826589 @default.
• W4380090350 cites W2069696438 @default.
• W4380090350 cites W2076895091 @default.
• W4380090350 cites W2079156404 @default.
• W4380090350 cites W2088749541 @default.
• W4380090350 cites W2098698214 @default.
• W4380090350 cites W2099431702 @default.
• W4380090350 cites W2101952870 @default.
• W4380090350 cites W2102891343 @default.
• W4380090350 cites W2105256330 @default.
• W4380090350 cites W2106302419 @default.
• W4380090350 cites W2116651275 @default.
• W4380090350 cites W2116746092 @default.
• W4380090350 cites W2119131032 @default.
• W4380090350 cites W2123558789 @default.
• W4380090350 cites W2132708041 @default.
• W4380090350 cites W2135617839 @default.
• W4380090350 cites W2137559718 @default.
• W4380090350 cites W2141197022 @default.
• W4380090350 cites W2141744105 @default.
• W4380090350 cites W2142011430 @default.
• W4380090350 cites W2143690341 @default.
• W4380090350 cites W2154500154 @default.
• W4380090350 cites W2155804510 @default.
• W4380090350 cites W2164551609 @default.
• W4380090350 cites W2168180694 @default.
• W4380090350 cites W2168249970 @default.
• W4380090350 cites W2169520827 @default.
• W4380090350 cites W2260748731 @default.
• W4380090350 cites W2315050537 @default.
• W4380090350 cites W2553902009 @default.
• W4380090350 cites W2784343369 @default.
• W4380090350 cites W2885072940 @default.
• W4380090350 cites W2954083118 @default.
• W4380090350 cites W2964113711 @default.
• W4380090350 cites W2982688814 @default.
• W4380090350 cites W3106906779 @default.
• W4380090350 doi "https://doi.org/10.1016/j.jbc.2023.104906" @default.
• W4380090350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37302555" @default.
• W4380090350 hasPublicationYear "2023" @default.
• W4380090350 type Work @default.
• W4380090350 citedByCount "1" @default.
• W4380090350 crossrefType "journal-article" @default.
• W4380090350 hasAuthorship W4380090350A5001079874 @default.
• W4380090350 hasAuthorship W4380090350A5005526622 @default.
• W4380090350 hasAuthorship W4380090350A5024592486 @default.
• W4380090350 hasAuthorship W4380090350A5045750845 @default.
• W4380090350 hasAuthorship W4380090350A5047677716 @default.
• W4380090350 hasAuthorship W4380090350A5079114350 @default.
• W4380090350 hasBestOaLocation W43800903501 @default.
• W4380090350 hasConcept C104317684 @default.
• W4380090350 hasConcept C153911025 @default.
• W4380090350 hasConcept C190062978 @default.
• W4380090350 hasConcept C194583182 @default.
• W4380090350 hasConcept C2776879804 @default.
• W4380090350 hasConcept C28859421 @default.
• W4380090350 hasConcept C36823959 @default.
• W4380090350 hasConcept C53345823 @default.
• W4380090350 hasConcept C54355233 @default.
• W4380090350 hasConcept C54458228 @default.
• W4380090350 hasConcept C67705224 @default.
• W4380090350 hasConcept C86803240 @default.
• W4380090350 hasConcept C94671646 @default.
• W4380090350 hasConcept C95444343 @default.
• W4380090350 hasConceptScore W4380090350C104317684 @default.
• W4380090350 hasConceptScore W4380090350C153911025 @default.
• W4380090350 hasConceptScore W4380090350C190062978 @default.

• next