FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380091339> ?p ?o ?g. }

• W4380091339 endingPage "116978" @default.
• W4380091339 startingPage "116978" @default.
• W4380091339 abstract "Duguetia stelechantha (Diels) R.E.Fr., popularly known as “ata brava” in Brazil, belongs to the Annonaceae family. Biologically active monoterpenes and sesquiterpenes identified in this genus and family, comprising a source of new drugs against several conditions, including leishmaniasis. In this context, the aim of the present study was to extract and chemically characterize the essential oil (EO-DU) obtained from D. stelechantha for the first time. The potential antileishmanial activity and in vitro cytotoxicity of an EO microemulsion (EO-ME) formulated with Tween 80 and Transcutol P surfactants were also evaluated. Duguetia stelechantha leaves were submitted to a hydrodistillation process and their chemical composition was determined by GC/MS. The major identified EO components were β-pinene (46.17 %), α-pinene (20.2 %), and spathulenol (6.68 %). A headspace characterization indicated major EO-DU compounds present in the prepared ME, confirming incorporation. The extracted EO was moderately active against Leishmania (L.) amazonensis promastigotes (IC50 =138.3 µg/mL), while the EO-ME was determined as active, inhibiting these parasites at a lower concentration (IC50 =4.47 µg/mL) compared to the EO-DU, indicating high selectivity against L. (L) amazonensis promastigotes. The major compound α-pinene was also tested, and presented IC50 = 64.78 µg/mL, considering it active against the tested parasites. Considering that D. stelechantha is an abundant species in the Brazilian Legal Amazon and that the antileishmanial potential of the extracted EO was enhanced by EM incorporation, this assessment provides relevant perspectives for future studies focused on the bioeconomy." @default.
• W4380091339 created "2023-06-10" @default.
• W4380091339 creator A5006275666 @default.
• W4380091339 creator A5006659248 @default.
• W4380091339 creator A5009047194 @default.
• W4380091339 creator A5018025903 @default.
• W4380091339 creator A5018930304 @default.
• W4380091339 creator A5045350261 @default.
• W4380091339 creator A5047875446 @default.
• W4380091339 creator A5054777653 @default.
• W4380091339 creator A5054970380 @default.
• W4380091339 creator A5081625701 @default.
• W4380091339 date "2023-10-01" @default.
• W4380091339 modified "2023-09-27" @default.
• W4380091339 title "Chemical composition and potential antileishmanial and cytotoxic activity of Duguetia stelechantha (Diels) R.E.Fr. essential oil" @default.
• W4380091339 cites W1509977541 @default.
• W4380091339 cites W1604267907 @default.
• W4380091339 cites W1971527906 @default.
• W4380091339 cites W2002002604 @default.
• W4380091339 cites W2004477508 @default.
• W4380091339 cites W2006313048 @default.
• W4380091339 cites W2044339866 @default.
• W4380091339 cites W2045740491 @default.
• W4380091339 cites W2058405196 @default.
• W4380091339 cites W2068481205 @default.
• W4380091339 cites W2077050915 @default.
• W4380091339 cites W2084826641 @default.
• W4380091339 cites W2102851131 @default.
• W4380091339 cites W2265312755 @default.
• W4380091339 cites W2670417476 @default.
• W4380091339 cites W2775643792 @default.
• W4380091339 cites W2919958803 @default.
• W4380091339 cites W2976260993 @default.
• W4380091339 cites W3038104412 @default.
• W4380091339 cites W3047612605 @default.
• W4380091339 cites W4224302810 @default.
• W4380091339 cites W4284699981 @default.
• W4380091339 cites W4295084326 @default.
• W4380091339 cites W758532171 @default.
• W4380091339 doi "https://doi.org/10.1016/j.indcrop.2023.116978" @default.
• W4380091339 hasPublicationYear "2023" @default.
• W4380091339 type Work @default.
• W4380091339 citedByCount "0" @default.
• W4380091339 crossrefType "journal-article" @default.
• W4380091339 hasAuthorship W4380091339A5006275666 @default.
• W4380091339 hasAuthorship W4380091339A5006659248 @default.
• W4380091339 hasAuthorship W4380091339A5009047194 @default.
• W4380091339 hasAuthorship W4380091339A5018025903 @default.
• W4380091339 hasAuthorship W4380091339A5018930304 @default.
• W4380091339 hasAuthorship W4380091339A5045350261 @default.
• W4380091339 hasAuthorship W4380091339A5047875446 @default.
• W4380091339 hasAuthorship W4380091339A5054777653 @default.
• W4380091339 hasAuthorship W4380091339A5054970380 @default.
• W4380091339 hasAuthorship W4380091339A5081625701 @default.
• W4380091339 hasConcept C109316439 @default.
• W4380091339 hasConcept C136764020 @default.
• W4380091339 hasConcept C138885662 @default.
• W4380091339 hasConcept C149849071 @default.
• W4380091339 hasConcept C151730666 @default.
• W4380091339 hasConcept C178790620 @default.
• W4380091339 hasConcept C185592680 @default.
• W4380091339 hasConcept C202751555 @default.
• W4380091339 hasConcept C2777278459 @default.
• W4380091339 hasConcept C2777671706 @default.
• W4380091339 hasConcept C2777752497 @default.
• W4380091339 hasConcept C2779343474 @default.
• W4380091339 hasConcept C2780303139 @default.
• W4380091339 hasConcept C2781092759 @default.
• W4380091339 hasConcept C31903555 @default.
• W4380091339 hasConcept C40231798 @default.
• W4380091339 hasConcept C41008148 @default.
• W4380091339 hasConcept C41895202 @default.
• W4380091339 hasConcept C55493867 @default.
• W4380091339 hasConcept C556039675 @default.
• W4380091339 hasConcept C59822182 @default.
• W4380091339 hasConcept C71240020 @default.
• W4380091339 hasConcept C71924100 @default.
• W4380091339 hasConcept C71928629 @default.
• W4380091339 hasConcept C86803240 @default.
• W4380091339 hasConcept C96529984 @default.
• W4380091339 hasConceptScore W4380091339C109316439 @default.
• W4380091339 hasConceptScore W4380091339C136764020 @default.
• W4380091339 hasConceptScore W4380091339C138885662 @default.
• W4380091339 hasConceptScore W4380091339C149849071 @default.
• W4380091339 hasConceptScore W4380091339C151730666 @default.
• W4380091339 hasConceptScore W4380091339C178790620 @default.
• W4380091339 hasConceptScore W4380091339C185592680 @default.
• W4380091339 hasConceptScore W4380091339C202751555 @default.
• W4380091339 hasConceptScore W4380091339C2777278459 @default.
• W4380091339 hasConceptScore W4380091339C2777671706 @default.
• W4380091339 hasConceptScore W4380091339C2777752497 @default.
• W4380091339 hasConceptScore W4380091339C2779343474 @default.
• W4380091339 hasConceptScore W4380091339C2780303139 @default.
• W4380091339 hasConceptScore W4380091339C2781092759 @default.
• W4380091339 hasConceptScore W4380091339C31903555 @default.
• W4380091339 hasConceptScore W4380091339C40231798 @default.
• W4380091339 hasConceptScore W4380091339C41008148 @default.
• W4380091339 hasConceptScore W4380091339C41895202 @default.

• next