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• W4380143029 endingPage "326" @default.
• W4380143029 startingPage "314" @default.
• W4380143029 abstract "Renal-cell carcinoma (RCC) remains a leading cause of cancer-related mortality worldwide. Though newer therapeutic combinations of immune checkpoint inhibitors and targeted therapies have greatly improved outcomes, resistance to these therapies is becoming a challenge for long-term control. Mechanisms of resistance have been explored in a variety of solid tumors, including RCC. Based upon our review of the current literature on the mechanisms of resistance to immunotherapies for the management of metastatic clear-cell renal cell carcinomas (mccRCC), the ensuing conclusions have been made: The management of mccRCC has progressed substantially with the advent of checkpoint inhibitors and targeted oral therapies, alone and/or in combination. Nevertheless, innate or developed resistance to these therapies remains an ongoing challenge, particularly to immune checkpoint inhibitors (ICIs). Several of the known mechanisms of resistance have been well defined, but recent progression in cellular therapies helps to expand the armamentarium of potential combination options that may overcome these modes of resistance and improve long-term disease control and survival for an otherwise dismal disease. In the ensuing review and update of the literature on the mechanisms of resistance to immunotherapies in mccRCC, we have revisited the known resistance mechanisms of immunotherapies in metastatic clear-cell RCC and explored ongoing and future strategies to overcome them." @default.
• W4380143029 created "2023-06-10" @default.
• W4380143029 creator A5014154182 @default.
• W4380143029 creator A5030475903 @default.
• W4380143029 creator A5052728390 @default.
• W4380143029 date "2023-01-01" @default.
• W4380143029 modified "2023-10-14" @default.
• W4380143029 title "Revisiting mechanisms of resistance to immunotherapies in metastatic clear-cell renal-cell carcinoma" @default.
• W4380143029 cites W1540592014 @default.
• W4380143029 cites W196236547 @default.
• W4380143029 cites W1969963445 @default.
• W4380143029 cites W1971358860 @default.
• W4380143029 cites W1981560649 @default.
• W4380143029 cites W1997292641 @default.
• W4380143029 cites W1999966467 @default.
• W4380143029 cites W2010160635 @default.
• W4380143029 cites W2033316540 @default.
• W4380143029 cites W2049491375 @default.
• W4380143029 cites W2071378220 @default.
• W4380143029 cites W2093541328 @default.
• W4380143029 cites W2099752220 @default.
• W4380143029 cites W2102575291 @default.
• W4380143029 cites W2123914905 @default.
• W4380143029 cites W2129310196 @default.
• W4380143029 cites W2138129102 @default.
• W4380143029 cites W2141269240 @default.
• W4380143029 cites W2143813821 @default.
• W4380143029 cites W2148605435 @default.
• W4380143029 cites W2149456801 @default.
• W4380143029 cites W2153867442 @default.
• W4380143029 cites W2163249181 @default.
• W4380143029 cites W2170069893 @default.
• W4380143029 cites W2185075416 @default.
• W4380143029 cites W2346108121 @default.
• W4380143029 cites W2415612552 @default.
• W4380143029 cites W2547869005 @default.
• W4380143029 cites W2552347134 @default.
• W4380143029 cites W2589053981 @default.
• W4380143029 cites W2592935721 @default.
• W4380143029 cites W2610313261 @default.
• W4380143029 cites W2747774814 @default.
• W4380143029 cites W2763265527 @default.
• W4380143029 cites W2766903152 @default.
• W4380143029 cites W2773804840 @default.
• W4380143029 cites W2782496117 @default.
• W4380143029 cites W2783970157 @default.
• W4380143029 cites W2787301955 @default.
• W4380143029 cites W2797429263 @default.
• W4380143029 cites W2810166643 @default.
• W4380143029 cites W2864786814 @default.
• W4380143029 cites W2903062212 @default.
• W4380143029 cites W2907028960 @default.
• W4380143029 cites W2913480997 @default.
• W4380143029 cites W2918019324 @default.
• W4380143029 cites W2946126594 @default.
• W4380143029 cites W2978665825 @default.
• W4380143029 cites W2985762613 @default.
• W4380143029 cites W2986907519 @default.
• W4380143029 cites W3008389148 @default.
• W4380143029 cites W3009486036 @default.
• W4380143029 cites W3014777836 @default.
• W4380143029 cites W3021579311 @default.
• W4380143029 cites W3030986893 @default.
• W4380143029 cites W3035208179 @default.
• W4380143029 cites W3042364418 @default.
• W4380143029 cites W3049040124 @default.
• W4380143029 cites W3082855561 @default.
• W4380143029 cites W3083183993 @default.
• W4380143029 cites W3090495129 @default.
• W4380143029 cites W3093923068 @default.
• W4380143029 cites W3118419510 @default.
• W4380143029 cites W3120650952 @default.
• W4380143029 cites W3131063362 @default.
• W4380143029 cites W3133229959 @default.
• W4380143029 cites W3135025774 @default.
• W4380143029 cites W3135253556 @default.
• W4380143029 cites W3148729173 @default.
• W4380143029 cites W3154810465 @default.
• W4380143029 cites W3169193862 @default.
• W4380143029 cites W3196207248 @default.
• W4380143029 cites W3202041569 @default.
• W4380143029 cites W3215271064 @default.
• W4380143029 cites W3216427242 @default.
• W4380143029 cites W4200201081 @default.
• W4380143029 cites W4200248834 @default.
• W4380143029 cites W4205710681 @default.
• W4380143029 cites W4210573911 @default.
• W4380143029 cites W4210684526 @default.
• W4380143029 cites W4210884666 @default.
• W4380143029 cites W4214706689 @default.
• W4380143029 cites W4220753283 @default.
• W4380143029 cites W4224220814 @default.
• W4380143029 cites W4225384737 @default.
• W4380143029 cites W4281645962 @default.
• W4380143029 cites W4288010536 @default.
• W4380143029 cites W4289516799 @default.
• W4380143029 cites W4292289227 @default.
• W4380143029 cites W4293708418 @default.

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