Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380147765> ?p ?o ?g. }
- W4380147765 endingPage "115563" @default.
- W4380147765 startingPage "115563" @default.
- W4380147765 abstract "Microwave-assisted reaction of 3,5-bis((E)-ylidene)-1-phosphonate-4-piperidones 3a‒g with azomethine ylide (produced through interaction of isatins 4 and sarcosine 5) cycloaddition afforded the corresponding dispiro[indoline-3,2′-pyrrolidine-3′,3″-piperidin]-1″-yl)phosphonates 6a‒l in excellent yields (80–95%). Structure of the synthesized agents was evidenced by single crystal X-ray studies of 6d, 6i and 6l. Some of the synthesized agents revealed promising anti-SARS-CoV-2 properties in the viral infected Vero-E6 cell technique with noticeable selectivity indices. Compounds 6g and 6b are the most promising agents synthesized (R = 4-BrC6H4, Ph; R' = H, Cl, respectively) with considerable selectivity index values. Mpro-SARS-CoV-2 inhibitory properties supported the anti-SARS-CoV-2 observations of the potent analogs synthesized. Molecular docking studies (PDB ID: 7C8U) are consistent with the Mpro inhibitory properties. The presumed mode of action was supported by both experimentally investigated Mpro-SARS-CoV-2 inhibitory properties and explained by docking observations." @default.
- W4380147765 created "2023-06-11" @default.
- W4380147765 creator A5018294904 @default.
- W4380147765 creator A5053844255 @default.
- W4380147765 creator A5066913644 @default.
- W4380147765 creator A5084441438 @default.
- W4380147765 creator A5084888196 @default.
- W4380147765 creator A5085558806 @default.
- W4380147765 date "2023-10-01" @default.
- W4380147765 modified "2023-10-01" @default.
- W4380147765 title "Spiroindole-containing compounds bearing phosphonate group of potential Mpro-SARS-CoV-2 inhibitory properties" @default.
- W4380147765 cites W2000694039 @default.
- W4380147765 cites W2001305417 @default.
- W4380147765 cites W2048762907 @default.
- W4380147765 cites W2061650977 @default.
- W4380147765 cites W2559015085 @default.
- W4380147765 cites W2940282309 @default.
- W4380147765 cites W2981286239 @default.
- W4380147765 cites W3004280078 @default.
- W4380147765 cites W3009881183 @default.
- W4380147765 cites W3012622856 @default.
- W4380147765 cites W3015613878 @default.
- W4380147765 cites W3023489051 @default.
- W4380147765 cites W3024946674 @default.
- W4380147765 cites W3042238480 @default.
- W4380147765 cites W3042289107 @default.
- W4380147765 cites W3045980011 @default.
- W4380147765 cites W3046566329 @default.
- W4380147765 cites W3081155245 @default.
- W4380147765 cites W3087485809 @default.
- W4380147765 cites W3107892561 @default.
- W4380147765 cites W3110503905 @default.
- W4380147765 cites W3113166651 @default.
- W4380147765 cites W3125283837 @default.
- W4380147765 cites W3125884511 @default.
- W4380147765 cites W3135193588 @default.
- W4380147765 cites W3150912981 @default.
- W4380147765 cites W3174652247 @default.
- W4380147765 cites W3176298565 @default.
- W4380147765 cites W3176751844 @default.
- W4380147765 cites W3190616317 @default.
- W4380147765 cites W3191422891 @default.
- W4380147765 cites W3196744857 @default.
- W4380147765 cites W3197127085 @default.
- W4380147765 cites W3199998540 @default.
- W4380147765 cites W3200890051 @default.
- W4380147765 cites W3204316700 @default.
- W4380147765 cites W3206509348 @default.
- W4380147765 cites W3211097250 @default.
- W4380147765 cites W4200575141 @default.
- W4380147765 cites W4205170082 @default.
- W4380147765 cites W4206067585 @default.
- W4380147765 cites W4206093347 @default.
- W4380147765 cites W4212880570 @default.
- W4380147765 cites W4213373202 @default.
- W4380147765 cites W4224296584 @default.
- W4380147765 cites W4280608228 @default.
- W4380147765 cites W4282579219 @default.
- W4380147765 cites W4292065674 @default.
- W4380147765 cites W4292210285 @default.
- W4380147765 cites W4292255243 @default.
- W4380147765 cites W4296017074 @default.
- W4380147765 cites W4306398979 @default.
- W4380147765 cites W4308744871 @default.
- W4380147765 cites W4309300818 @default.
- W4380147765 cites W4318305485 @default.
- W4380147765 doi "https://doi.org/10.1016/j.ejmech.2023.115563" @default.
- W4380147765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37329713" @default.
- W4380147765 hasPublicationYear "2023" @default.
- W4380147765 type Work @default.
- W4380147765 citedByCount "1" @default.
- W4380147765 countsByYear W43801477652023 @default.
- W4380147765 crossrefType "journal-article" @default.
- W4380147765 hasAuthorship W4380147765A5018294904 @default.
- W4380147765 hasAuthorship W4380147765A5053844255 @default.
- W4380147765 hasAuthorship W4380147765A5066913644 @default.
- W4380147765 hasAuthorship W4380147765A5084441438 @default.
- W4380147765 hasAuthorship W4380147765A5084888196 @default.
- W4380147765 hasAuthorship W4380147765A5085558806 @default.
- W4380147765 hasConcept C118792377 @default.
- W4380147765 hasConcept C159110408 @default.
- W4380147765 hasConcept C161790260 @default.
- W4380147765 hasConcept C169760540 @default.
- W4380147765 hasConcept C17077164 @default.
- W4380147765 hasConcept C178790620 @default.
- W4380147765 hasConcept C185592680 @default.
- W4380147765 hasConcept C202751555 @default.
- W4380147765 hasConcept C21951064 @default.
- W4380147765 hasConcept C2777626080 @default.
- W4380147765 hasConcept C2777756961 @default.
- W4380147765 hasConcept C2778851528 @default.
- W4380147765 hasConcept C2779664164 @default.
- W4380147765 hasConcept C2779890007 @default.
- W4380147765 hasConcept C2779943223 @default.
- W4380147765 hasConcept C41685203 @default.
- W4380147765 hasConcept C515207424 @default.
- W4380147765 hasConcept C55493867 @default.
- W4380147765 hasConcept C71240020 @default.