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- W4380149009 abstract "Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (achesb55/+) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system." @default.
- W4380149009 created "2023-06-11" @default.
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- W4380149009 date "2023-06-01" @default.
- W4380149009 modified "2023-09-26" @default.
- W4380149009 title "Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system" @default.
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- W4380149009 doi "https://doi.org/10.1016/j.neurobiolaging.2023.06.005" @default.
- W4380149009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37419077" @default.
- W4380149009 hasPublicationYear "2023" @default.
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