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- W4380149145 endingPage "103666" @default.
- W4380149145 startingPage "103666" @default.
- W4380149145 abstract "Immune checkpoint inhibitors (ICIs) have revolutionized treatment in oncology. Antibodies against PD-1/PD-L1 and ICI-based combinations are under clinical investigations in multiple cancers, including ovarian cancer. However, the success of ICIs has not materialized in ovarian cancer, which remains one of the few malignancies where ICIs exhibit modest efficacy as either monotherapy or combination therapy. In this review, we summarize completed and ongoing clinical trials of PD-1/PD-L1 blockade in ovarian cancer, categorize the underlying mechanisms of resistance emergence, and introduce candidate approaches to rewire the tumor microenvironment (TME) to potentiate anti-PD-1/PD-L1 antibodies." @default.
- W4380149145 created "2023-06-11" @default.
- W4380149145 creator A5021630418 @default.
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- W4380149145 creator A5070897349 @default.
- W4380149145 creator A5092131866 @default.
- W4380149145 date "2023-08-01" @default.
- W4380149145 modified "2023-10-16" @default.
- W4380149145 title "PD-1/PD-L1 immune checkpoint blockade in ovarian cancer: Dilemmas and opportunities" @default.
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- W4380149145 doi "https://doi.org/10.1016/j.drudis.2023.103666" @default.
- W4380149145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37302543" @default.
- W4380149145 hasPublicationYear "2023" @default.
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