FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380153616> ?p ?o ?g. }

• W4380153616 abstract "Bacteriophages, which selectively infect bacteria, and phage-derived structures are considered promising agents for the diagnosis and treatment of bacterial infections due to the increasing antibiotic resistance. The binding of phages to their specific receptors on host bacteria is highly specific and irreversible, and therefore, the characterization of receptor-binding proteins(RBPs), which are key determinants of phage specificity, is crucial for the development of new diagnostic and therapeutic products. This study highlights the biotechnological potential of Gp144, an RBP located in the tail baseplate of bacteriophage K and responsible for adsorption of phageK to S. aureus. Once it was established that recombinant Gp144 (rGp144)is biocompatible and does not exhibit lytic effects on bacteria, its interaction with the host, the binding efficiency and performance were assessed in vitro using microscopic and serological methods. Results showed that rGp144 has a capture efficiency (CE) of over 87% and the best CE score is %96 which captured 9 CFU mL−1 out of 10 CFU mL−1 bacteria, indicating that very low number of bacteria could be detected. Additionally, it was shown for the first time in the literature that rGp144 binds to both S. aureus and methicillin-resistant S. aureus (MRSA) cells in vitro, while its affinity to different Gram-positive bacteria (E. faecalis and B. cereus) was not observed. The findings suggest that rGp144 can be effectively used for the diagnosis of S. aureus and MRSA, and that the use of RBPs in host-phage interaction can be a novel and effective strategy for imaging and diagnosing the site of infection." @default.
• W4380153616 created "2023-06-11" @default.
• W4380153616 creator A5002783391 @default.
• W4380153616 creator A5005465714 @default.
• W4380153616 creator A5032951336 @default.
• W4380153616 creator A5037051254 @default.
• W4380153616 creator A5092133427 @default.
• W4380153616 creator A5092133428 @default.
• W4380153616 date "2023-06-23" @default.
• W4380153616 modified "2023-10-14" @default.
• W4380153616 title "The evaluation of biotechnological potential of Gp144, the key molecule of natural predator bacteriophage K in <i>Staphylococcus aureus</i> hunting mechanism" @default.
• W4380153616 cites W1815444836 @default.
• W4380153616 cites W1968611319 @default.
• W4380153616 cites W1978447041 @default.
• W4380153616 cites W1985820516 @default.
• W4380153616 cites W1999441390 @default.
• W4380153616 cites W2003435491 @default.
• W4380153616 cites W2008335524 @default.
• W4380153616 cites W2017914903 @default.
• W4380153616 cites W2020414349 @default.
• W4380153616 cites W2038077583 @default.
• W4380153616 cites W2043659487 @default.
• W4380153616 cites W2050434089 @default.
• W4380153616 cites W2063550722 @default.
• W4380153616 cites W2074524562 @default.
• W4380153616 cites W2083923708 @default.
• W4380153616 cites W2093915796 @default.
• W4380153616 cites W2103272182 @default.
• W4380153616 cites W2104950873 @default.
• W4380153616 cites W2108666079 @default.
• W4380153616 cites W2124798492 @default.
• W4380153616 cites W2127322768 @default.
• W4380153616 cites W2138186521 @default.
• W4380153616 cites W2154918152 @default.
• W4380153616 cites W2155844662 @default.
• W4380153616 cites W2300793209 @default.
• W4380153616 cites W2301127062 @default.
• W4380153616 cites W2344195204 @default.
• W4380153616 cites W2347102183 @default.
• W4380153616 cites W2400558032 @default.
• W4380153616 cites W2402291029 @default.
• W4380153616 cites W2419630738 @default.
• W4380153616 cites W2505184922 @default.
• W4380153616 cites W2568822272 @default.
• W4380153616 cites W2593927309 @default.
• W4380153616 cites W2765413139 @default.
• W4380153616 cites W2800979037 @default.
• W4380153616 cites W2801273097 @default.
• W4380153616 cites W2887223800 @default.
• W4380153616 cites W2917508998 @default.
• W4380153616 cites W2969178770 @default.
• W4380153616 cites W2982302744 @default.
• W4380153616 cites W2982518677 @default.
• W4380153616 cites W2999569426 @default.
• W4380153616 cites W3000823447 @default.
• W4380153616 cites W3006996481 @default.
• W4380153616 cites W3014757079 @default.
• W4380153616 cites W3036094427 @default.
• W4380153616 cites W3042755033 @default.
• W4380153616 cites W3044809167 @default.
• W4380153616 cites W3093052649 @default.
• W4380153616 cites W3164161806 @default.
• W4380153616 cites W3166271061 @default.
• W4380153616 cites W3172750124 @default.
• W4380153616 cites W3178961535 @default.
• W4380153616 cites W3196953650 @default.
• W4380153616 cites W3203117536 @default.
• W4380153616 cites W4224938356 @default.
• W4380153616 cites W4229003516 @default.
• W4380153616 cites W4310012181 @default.
• W4380153616 cites W4317726023 @default.
• W4380153616 doi "https://doi.org/10.1002/biot.202300145" @default.
• W4380153616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37300362" @default.
• W4380153616 hasPublicationYear "2023" @default.
• W4380153616 type Work @default.
• W4380153616 citedByCount "0" @default.
• W4380153616 crossrefType "journal-article" @default.
• W4380153616 hasAuthorship W4380153616A5002783391 @default.
• W4380153616 hasAuthorship W4380153616A5005465714 @default.
• W4380153616 hasAuthorship W4380153616A5032951336 @default.
• W4380153616 hasAuthorship W4380153616A5037051254 @default.
• W4380153616 hasAuthorship W4380153616A5092133427 @default.
• W4380153616 hasAuthorship W4380153616A5092133428 @default.
• W4380153616 hasConcept C10389963 @default.
• W4380153616 hasConcept C104317684 @default.
• W4380153616 hasConcept C159047783 @default.
• W4380153616 hasConcept C182615771 @default.
• W4380153616 hasConcept C2522874641 @default.
• W4380153616 hasConcept C2776441376 @default.
• W4380153616 hasConcept C2779489039 @default.
• W4380153616 hasConcept C523546767 @default.
• W4380153616 hasConcept C54355233 @default.
• W4380153616 hasConcept C547475151 @default.
• W4380153616 hasConcept C55493867 @default.
• W4380153616 hasConcept C57326107 @default.
• W4380153616 hasConcept C86803240 @default.
• W4380153616 hasConcept C89423630 @default.
• W4380153616 hasConceptScore W4380153616C10389963 @default.
• W4380153616 hasConceptScore W4380153616C104317684 @default.
• W4380153616 hasConceptScore W4380153616C159047783 @default.

• next