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- W4380154477 abstract "Historically, anticoagulants were contraindicated in patients with cirrhosis owing to concerns about bleeding risks. However, recent studies have shown that patients with cirrhosis are not naturally anticoagulated and are at increased risk of prothrombotic events, such as portal venous thrombosis. In this article, we review preclinical and clinical data on the effects of anticoagulants in cirrhosis, including their potential benefits in reducing liver fibrosis, portal hypertension, and improving survival. Despite promising preclinical evidence, clinical translation has proven challenging. Nevertheless, we discuss the use of anticoagulation in specific clinical scenarios, such as patients with atrial fibrillation and portal vein thrombosis, and highlight the need for further research, including randomised-controlled trials, to determine the optimal role of anticoagulants in the management of patients with cirrhosis. .: Trial registration number: not available." @default.
- W4380154477 created "2023-06-11" @default.
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- W4380154477 date "2023-06-01" @default.
- W4380154477 modified "2023-10-18" @default.
- W4380154477 title "A major research gap: the use of anticoagulants in cirrhosis" @default.
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- W4380154477 doi "https://doi.org/10.1016/j.jhep.2023.06.001" @default.
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