Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380184811> ?p ?o ?g. }
- W4380184811 endingPage "143968" @default.
- W4380184811 startingPage "143968" @default.
- W4380184811 abstract "Dry eye disease (DED) has become a globally recognized public health problem with complex pathogenesis. Recent studies showed that oxidative stress damage and its induced inflammation are the main contributors to the occurrence and progression of dry eye. Here, a novel antioxidative and reactive oxygen species (ROS)-responsive micellar system is reported to improve the ocular surface delivery of highly hydrophobic immunosuppressive cyclosporine A (CSA). This drug carrier is utilized together with the loaded anti-inflammatory drug to achieve a combinatorial treatment of DED. In detail, the selenium substituted random copolymer Se-PEG-PPG is the key to such design, which self-assembles into cornea-penetrating nanoscale micelles with a neutral shell and small size (<50 nm). The Se-PEG-PPG micelles also exerted synergetic therapeutic effects by decreasing intracellular oxidative stress and inhibiting cell apoptosis because of the ROS-scavenging selenium ether group. Finally, the combinatorial anti-oxidation, anti-inflammation, and therapeutic effects of CSA@Se-PEG-PPG eye drops were demonstrated in a murine dry eye model. Taken together, this multifunctional drug delivery system provides a promising approach for the treatment of DED and various ROS-related ocular diseases." @default.
- W4380184811 created "2023-06-11" @default.
- W4380184811 creator A5002459266 @default.
- W4380184811 creator A5003551515 @default.
- W4380184811 creator A5010651483 @default.
- W4380184811 creator A5025978034 @default.
- W4380184811 creator A5039590366 @default.
- W4380184811 creator A5070037392 @default.
- W4380184811 creator A5076594501 @default.
- W4380184811 creator A5077459187 @default.
- W4380184811 creator A5083694400 @default.
- W4380184811 date "2023-08-01" @default.
- W4380184811 modified "2023-10-16" @default.
- W4380184811 title "Highly effective corneal permeability of reactive oxygen species-responsive nano-formulation encapsulated cyclosporine a for dry eye management" @default.
- W4380184811 cites W1981125406 @default.
- W4380184811 cites W2001682689 @default.
- W4380184811 cites W2008878337 @default.
- W4380184811 cites W2009473148 @default.
- W4380184811 cites W2011777137 @default.
- W4380184811 cites W2013612819 @default.
- W4380184811 cites W2021182217 @default.
- W4380184811 cites W2023378519 @default.
- W4380184811 cites W2047763238 @default.
- W4380184811 cites W2058556985 @default.
- W4380184811 cites W2067545345 @default.
- W4380184811 cites W2110273114 @default.
- W4380184811 cites W2120124870 @default.
- W4380184811 cites W2137485942 @default.
- W4380184811 cites W2146296415 @default.
- W4380184811 cites W2154855352 @default.
- W4380184811 cites W2155596800 @default.
- W4380184811 cites W2192161449 @default.
- W4380184811 cites W2339025303 @default.
- W4380184811 cites W2339635819 @default.
- W4380184811 cites W2354491835 @default.
- W4380184811 cites W2512928733 @default.
- W4380184811 cites W2520252358 @default.
- W4380184811 cites W2607103004 @default.
- W4380184811 cites W2737439597 @default.
- W4380184811 cites W2737642784 @default.
- W4380184811 cites W2739410682 @default.
- W4380184811 cites W2749350888 @default.
- W4380184811 cites W2754858754 @default.
- W4380184811 cites W2845613736 @default.
- W4380184811 cites W2889860165 @default.
- W4380184811 cites W2903292093 @default.
- W4380184811 cites W2921487630 @default.
- W4380184811 cites W2923651815 @default.
- W4380184811 cites W2949375659 @default.
- W4380184811 cites W2950592329 @default.
- W4380184811 cites W2952792119 @default.
- W4380184811 cites W2999020165 @default.
- W4380184811 cites W3008785449 @default.
- W4380184811 cites W3034955506 @default.
- W4380184811 cites W3107483346 @default.
- W4380184811 cites W3112659503 @default.
- W4380184811 cites W3118369113 @default.
- W4380184811 cites W3126675065 @default.
- W4380184811 cites W3126907409 @default.
- W4380184811 cites W3134294215 @default.
- W4380184811 cites W3155704152 @default.
- W4380184811 cites W3157738847 @default.
- W4380184811 cites W3159765728 @default.
- W4380184811 cites W3183638498 @default.
- W4380184811 cites W3183997075 @default.
- W4380184811 cites W3208137158 @default.
- W4380184811 cites W3210477005 @default.
- W4380184811 cites W4206562384 @default.
- W4380184811 cites W4207074865 @default.
- W4380184811 cites W4224130009 @default.
- W4380184811 doi "https://doi.org/10.1016/j.cej.2023.143968" @default.
- W4380184811 hasPublicationYear "2023" @default.
- W4380184811 type Work @default.
- W4380184811 citedByCount "0" @default.
- W4380184811 crossrefType "journal-article" @default.
- W4380184811 hasAuthorship W4380184811A5002459266 @default.
- W4380184811 hasAuthorship W4380184811A5003551515 @default.
- W4380184811 hasAuthorship W4380184811A5010651483 @default.
- W4380184811 hasAuthorship W4380184811A5025978034 @default.
- W4380184811 hasAuthorship W4380184811A5039590366 @default.
- W4380184811 hasAuthorship W4380184811A5070037392 @default.
- W4380184811 hasAuthorship W4380184811A5076594501 @default.
- W4380184811 hasAuthorship W4380184811A5077459187 @default.
- W4380184811 hasAuthorship W4380184811A5083694400 @default.
- W4380184811 hasConcept C10138342 @default.
- W4380184811 hasConcept C11268172 @default.
- W4380184811 hasConcept C118487528 @default.
- W4380184811 hasConcept C12554922 @default.
- W4380184811 hasConcept C162324750 @default.
- W4380184811 hasConcept C178790620 @default.
- W4380184811 hasConcept C184651966 @default.
- W4380184811 hasConcept C185592680 @default.
- W4380184811 hasConcept C190283241 @default.
- W4380184811 hasConcept C203014093 @default.
- W4380184811 hasConcept C2776151105 @default.
- W4380184811 hasConcept C2776882836 @default.
- W4380184811 hasConcept C2776914184 @default.
- W4380184811 hasConcept C2779820397 @default.