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- W4380185690 abstract "Pharyngocutaneous fistulas after salvage laryngectomy are a frequent, serious complication with increased morbidity. Due to the unfavorable tissue conditions after radiotherapy, such fistulas are difficult to treat therapeutically and in a high percentage are associated with a significantly prolonged hospital stay. A fistula closure with degradable polymeric implant materials instead of a skin muscle flap would represent a novel therapy option in oncological head and neck surgery. After histopathological confirmation of adenoid cystic carcinoma of the larynx, a 72-year-old female patient underwent primary radiotherapy of the laryngeal region and the regional lymphatic drainage followed by heavy ion irradiation. After histopathologic confirmation of recurrence followed by salvage laryngectomy, the patient developed 3 pharyngocutaneous fistulas. After multiple attempts at surgical fistula closure, coverage of the fistulas with SUPRATHEL in a three-layer modification is performed as an off-label use. SUPRATHEL is an innovative biodegradable microporous membrane approved for alloplastic skin replacement for the treatment of epidermal and dermal wounds. According to the initial clinical experience in the pharyngeal environment, the biodegradable microporous membrane has sufficient chemical, enzymatic and bacterial stability. After SUPRATHEL defect coverage of two pharyngocutaneous fistulas, rapid granulation within 12 days and in the further course a permanent closure of the two fistulas without local problems like inflammation was shown. In a next step, the application of SUPRATHEL will be validated orally and pharyngeally in larger studies." @default.
- W4380185690 created "2023-06-11" @default.
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- W4380185690 date "2023-05-01" @default.
- W4380185690 modified "2023-09-25" @default.
- W4380185690 title "First clinical experience on the use of polymeric implant materials for the closure of a pharyngocutaneous fistula after postradiogenic laryngectomy" @default.
- W4380185690 doi "https://doi.org/10.1055/s-0043-1767232" @default.
- W4380185690 hasPublicationYear "2023" @default.
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