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- W4380185989 abstract "Relapse of acute lymphoblastic leukemia (ALL) in children/adolescence occurs in half of male patients with an extramedullary involvement in the testis. The molecular and cellular mechanisms, why leukemic cells preferentially migrate to and survive in the testis have not been systematically assessed. We aimed at characterizing the testicular and the bone marrow niche of ALL cells. We analyzed testicular and bone marrow samples of male pediatric patients using RNASeq and imaging mass cytometry. Our data reveal the physiological immune suppressive microenvironment in the testis compared to the bone marrow. In contrast, we observed a inflammatory environment because of massive leukemic cell proliferation within the tight organ, but an additional immune suppression by the leukemia. There was an increase in apoptosis suppression and DNA repair compared to the bone marrow. We identified different pathways upregulated, supporting the survival of leukemia cells in the testis. In conclusion, the leukemia infiltrated testis is a unique physiologically and pathophysiologically microenvironment, which explains the preferential survival and chemotherapy resistance of in this compartment." @default.
- W4380185989 created "2023-06-11" @default.
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- W4380185989 date "2023-05-01" @default.
- W4380185989 modified "2023-09-30" @default.
- W4380185989 title "The transcriptional landscape and the immune microenvironment of the testicular niche in pediatric ALL" @default.
- W4380185989 doi "https://doi.org/10.1055/s-0043-1768518" @default.
- W4380185989 hasPublicationYear "2023" @default.
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