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- W4380185997 abstract "Only recently, it is known that small extracellular vesicles (sEVs) released by AML cells induce molecular changes in the bone marrow niche (BMN) and transform BMN into leukemia permissive niche. However, it remains unclear which biological cargo from AML-derived sEVs has a functional role in BMN. We found that MV4-11 sEVs influence the normal hematopoietic function in healthy bone marrow-derived mesenchymal stromal cells (BM-MSCs) leading to increased proliferation and decreased differentiation. Next, LC-MS proteomics revealed that many proteins including YBX1 are upregulated in both untreated MV4-11 sEVs and healthy BM-MSCs treated with MV4-11 sEVs. Supporting this, we found that YBX1 is significantly upregulated in AML patients-derived sEVs compared to healthy controls. Interestingly, incubation of healthy BM-MSCs with sEVs isolated from MV4-11 cells with pharmacological YBX1 inhibitor or downregulating YBX1 using siRNA conditions significantly rescued the observed effect of proliferation and differentiation. Altogether, we revealed that YBX1 is a novel protein in AML-derived sEVs, which disrupts normal hematopoiesis in BMN by influencing the differentiation of BM-MSCs." @default.
- W4380185997 created "2023-06-11" @default.
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- W4380185997 date "2023-05-01" @default.
- W4380185997 modified "2023-10-18" @default.
- W4380185997 title "AML-derived small EVs containing YBX1 influences mesenchymal stromal cells differentiation in the bone marrow niche" @default.
- W4380185997 doi "https://doi.org/10.1055/s-0043-1768504" @default.
- W4380185997 hasPublicationYear "2023" @default.
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