Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380200212> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4380200212 abstract "ABSTRACT The association of thyroid disease and diabetes has been classically described. However, the comorbidity of thyroid disparities and insulin resistance is not frequently assessed, especially the sequence of the occurrence of these markers. We performed a retrospective analysis to evaluate the association between thyroid disease and diabetes markers. We further investigated the sequence of occurrence of thyroid and diabetes markers to identify any predictive capabilities of these markers. We evaluated 32787 subjects who were classified based on their serum thyroid hormones and autoantibody levels. Our general prevalence results showed that HOMA-IR was elevated in overt hypothyroid subjects (43.7%) and overt hyperthyroid subjects (42.2%). HbA1C was elevated in subclinical hypothyroid subjects (19.2%), overt hypothyroid subjects (22.3%) and overt hyperthyroid subjects (21.2%). Glucose was significantly elevated in subclinical hypothyroid subjects (24.2%) and overt hyperthyroid subjects (31.0%). Insulin was only significantly elevated in overt hypothyroid subjects (15.1%). Interestingly, we found that 70.3% of subjects who had their HOMA-IR score escalated from negative (HOMA-IR<2.7) to positive (HOMA-IR>2.7) during their multiple visits had anti-TPO 369 (±242) days prior to the onset of this change. Our comprehensive study provided evidence that the presence of anti-TPO may suggest a predictive role in developing insulin resistance later in life. Strengths and limitations of the study The strength of our study is the large population size including a larger set of markers from both thyroid disease and diabetes. The limitation in our study is the distorted male and female ratio." @default.
- W4380200212 created "2023-06-11" @default.
- W4380200212 creator A5005741793 @default.
- W4380200212 creator A5008062007 @default.
- W4380200212 creator A5019054909 @default.
- W4380200212 creator A5020341187 @default.
- W4380200212 creator A5039400193 @default.
- W4380200212 creator A5052050094 @default.
- W4380200212 creator A5067409693 @default.
- W4380200212 creator A5070488338 @default.
- W4380200212 date "2023-06-10" @default.
- W4380200212 modified "2023-09-24" @default.
- W4380200212 title "Insulin resistance in thyroid disorders: association between anti-TPO and HOMA-IR" @default.
- W4380200212 cites W1968755349 @default.
- W4380200212 cites W2004218991 @default.
- W4380200212 cites W2022648150 @default.
- W4380200212 cites W2047252235 @default.
- W4380200212 cites W2057203165 @default.
- W4380200212 cites W2059175981 @default.
- W4380200212 cites W2064379915 @default.
- W4380200212 cites W2089853303 @default.
- W4380200212 cites W2096420477 @default.
- W4380200212 cites W2124195624 @default.
- W4380200212 cites W2132380505 @default.
- W4380200212 cites W2135957850 @default.
- W4380200212 cites W2141938606 @default.
- W4380200212 cites W2142366400 @default.
- W4380200212 cites W2160234571 @default.
- W4380200212 cites W2167323205 @default.
- W4380200212 cites W2169482975 @default.
- W4380200212 doi "https://doi.org/10.1101/2023.06.06.23291013" @default.
- W4380200212 hasPublicationYear "2023" @default.
- W4380200212 type Work @default.
- W4380200212 citedByCount "0" @default.
- W4380200212 crossrefType "posted-content" @default.
- W4380200212 hasAuthorship W4380200212A5005741793 @default.
- W4380200212 hasAuthorship W4380200212A5008062007 @default.
- W4380200212 hasAuthorship W4380200212A5019054909 @default.
- W4380200212 hasAuthorship W4380200212A5020341187 @default.
- W4380200212 hasAuthorship W4380200212A5039400193 @default.
- W4380200212 hasAuthorship W4380200212A5052050094 @default.
- W4380200212 hasAuthorship W4380200212A5067409693 @default.
- W4380200212 hasAuthorship W4380200212A5070488338 @default.
- W4380200212 hasBestOaLocation W43802002121 @default.
- W4380200212 hasConcept C113280763 @default.
- W4380200212 hasConcept C126322002 @default.
- W4380200212 hasConcept C134018914 @default.
- W4380200212 hasConcept C2777180221 @default.
- W4380200212 hasConcept C2777391703 @default.
- W4380200212 hasConcept C2780176905 @default.
- W4380200212 hasConcept C2908647359 @default.
- W4380200212 hasConcept C526584372 @default.
- W4380200212 hasConcept C555293320 @default.
- W4380200212 hasConcept C71924100 @default.
- W4380200212 hasConcept C99454951 @default.
- W4380200212 hasConceptScore W4380200212C113280763 @default.
- W4380200212 hasConceptScore W4380200212C126322002 @default.
- W4380200212 hasConceptScore W4380200212C134018914 @default.
- W4380200212 hasConceptScore W4380200212C2777180221 @default.
- W4380200212 hasConceptScore W4380200212C2777391703 @default.
- W4380200212 hasConceptScore W4380200212C2780176905 @default.
- W4380200212 hasConceptScore W4380200212C2908647359 @default.
- W4380200212 hasConceptScore W4380200212C526584372 @default.
- W4380200212 hasConceptScore W4380200212C555293320 @default.
- W4380200212 hasConceptScore W4380200212C71924100 @default.
- W4380200212 hasConceptScore W4380200212C99454951 @default.
- W4380200212 hasLocation W43802002121 @default.
- W4380200212 hasOpenAccess W4380200212 @default.
- W4380200212 hasPrimaryLocation W43802002121 @default.
- W4380200212 hasRelatedWork W1979252938 @default.
- W4380200212 hasRelatedWork W2032225465 @default.
- W4380200212 hasRelatedWork W2169206971 @default.
- W4380200212 hasRelatedWork W2378290744 @default.
- W4380200212 hasRelatedWork W2584731720 @default.
- W4380200212 hasRelatedWork W2748952813 @default.
- W4380200212 hasRelatedWork W2886303208 @default.
- W4380200212 hasRelatedWork W2910989958 @default.
- W4380200212 hasRelatedWork W2969331335 @default.
- W4380200212 hasRelatedWork W3028840175 @default.
- W4380200212 isParatext "false" @default.
- W4380200212 isRetracted "false" @default.
- W4380200212 workType "article" @default.