FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380201013> ?p ?o ?g. }

• W4380201013 abstract "The bidentate (N, O) donor Schiff base, methyl-4-(2-hydroxybenzylidene-amino) benzoate (HL), was synthesized for the synthesis of CuL2 complex. Their structures were characterized by single crystal X-ray diffraction and spectroscopic methods. The important structural features of ligand HL are (space group: Pca21; a = 6.1434(7) Å; b = 7.1021(7) Å; c = 28.963(3) Å; α = 90.00°; β = 90.00°, and γ = 90.00°) and of CuL2 are (space group: P21/n; a = 15.763(7) Å; b = 8.1921(5) Å, and c = 20.1955(8) Å; α = 90.00°; β = 96.547(4)°, and γ = 90.00°). The DFT/TD-DFT studies were performed to evaluate the structure optimization, MEP plot, and electronic spectroscopy data as well as the HOMO-LUMO energy and also other electronic descriptor properties. The DNA and BSA binding property of both the ligand and complex were studied employing a variety of spectroscopic methods, viscosity experiments, and gel electrophoresis technique. Their biophysical study including 3D fluorescence, FRET calculation, and anisotropy measurements with BSA were studied by spectrofluorometric methods. The molecular docking simulation of the ligand HL and CuL2 was executed with DNA and BSA to observe their different weak and strong binding interactions and to compare their binding aptitude with biomolecules and experimental results. The software “PASS” for drug likeness prediction and “ADMET” for bioactivity were implemented to get an idea about the antineoplastic and bioactivity aspects of HL and CuL2 complex. The anticancer property of the Cu(II) complex was measured by MTT assay against human breast carcinomas (MCF-7) cancer cell line and as well as normal human embryonic kidney cells (HEK293) and is less toxic and comparable anticancer activity compared to cisplatin and oxaliplatin. The annexin V-FITC, propidium iodide assay by flow cytometric method, and reactive oxygen species (ROS) production assay by DCFDA were assessed in presence of the HL and CuL2 for their cell death mechanism proceed via either apoptosis or necrosis." @default.
• W4380201013 created "2023-06-11" @default.
• W4380201013 creator A5005274918 @default.
• W4380201013 creator A5022675060 @default.
• W4380201013 creator A5023094303 @default.
• W4380201013 creator A5032578636 @default.
• W4380201013 creator A5036812155 @default.
• W4380201013 creator A5052662972 @default.
• W4380201013 creator A5069623368 @default.
• W4380201013 creator A5082022074 @default.
• W4380201013 date "2023-06-09" @default.
• W4380201013 modified "2023-10-16" @default.
• W4380201013 title "Biophysical study on DNA and BSA binding activity of Cu(II) complex: Synthesis, molecular docking, cytotoxic activity, and theoretical approach" @default.
• W4380201013 cites W1602844435 @default.
• W4380201013 cites W1936626203 @default.
• W4380201013 cites W1971326367 @default.
• W4380201013 cites W1971923258 @default.
• W4380201013 cites W1976432385 @default.
• W4380201013 cites W1980888233 @default.
• W4380201013 cites W1986406178 @default.
• W4380201013 cites W1992634290 @default.
• W4380201013 cites W2001964759 @default.
• W4380201013 cites W2001976945 @default.
• W4380201013 cites W2004884180 @default.
• W4380201013 cites W2015211009 @default.
• W4380201013 cites W2042218168 @default.
• W4380201013 cites W2044152887 @default.
• W4380201013 cites W2048168597 @default.
• W4380201013 cites W2050569993 @default.
• W4380201013 cites W2057891803 @default.
• W4380201013 cites W2059828654 @default.
• W4380201013 cites W2065791357 @default.
• W4380201013 cites W2068609215 @default.
• W4380201013 cites W2068688104 @default.
• W4380201013 cites W2074078791 @default.
• W4380201013 cites W2074995319 @default.
• W4380201013 cites W2076020561 @default.
• W4380201013 cites W2076494430 @default.
• W4380201013 cites W2084516911 @default.
• W4380201013 cites W2085083391 @default.
• W4380201013 cites W2087521850 @default.
• W4380201013 cites W2089073810 @default.
• W4380201013 cites W2111692492 @default.
• W4380201013 cites W2114355493 @default.
• W4380201013 cites W2116326663 @default.
• W4380201013 cites W2123266041 @default.
• W4380201013 cites W2130054883 @default.
• W4380201013 cites W2144825640 @default.
• W4380201013 cites W2146964352 @default.
• W4380201013 cites W2150189550 @default.
• W4380201013 cites W2151773675 @default.
• W4380201013 cites W2280796240 @default.
• W4380201013 cites W2323142798 @default.
• W4380201013 cites W2334138351 @default.
• W4380201013 cites W2344984955 @default.
• W4380201013 cites W2382154910 @default.
• W4380201013 cites W2549078338 @default.
• W4380201013 cites W2578144494 @default.
• W4380201013 cites W2602374030 @default.
• W4380201013 cites W2793695646 @default.
• W4380201013 cites W2801816908 @default.
• W4380201013 cites W2808404936 @default.
• W4380201013 cites W2923983951 @default.
• W4380201013 cites W2998599392 @default.
• W4380201013 cites W3008722627 @default.
• W4380201013 cites W3023603602 @default.
• W4380201013 cites W3037472179 @default.
• W4380201013 cites W3088002071 @default.
• W4380201013 cites W3130825823 @default.
• W4380201013 cites W3174493092 @default.
• W4380201013 cites W3186753927 @default.
• W4380201013 cites W3188780109 @default.
• W4380201013 cites W3205210885 @default.
• W4380201013 cites W4200369117 @default.
• W4380201013 cites W4214871575 @default.
• W4380201013 cites W4223540851 @default.
• W4380201013 cites W4296232856 @default.
• W4380201013 cites W4317934229 @default.
• W4380201013 doi "https://doi.org/10.1002/aoc.7164" @default.
• W4380201013 hasPublicationYear "2023" @default.
• W4380201013 type Work @default.
• W4380201013 citedByCount "0" @default.
• W4380201013 crossrefType "journal-article" @default.
• W4380201013 hasAuthorship W4380201013A5005274918 @default.
• W4380201013 hasAuthorship W4380201013A5022675060 @default.
• W4380201013 hasAuthorship W4380201013A5023094303 @default.
• W4380201013 hasAuthorship W4380201013A5032578636 @default.
• W4380201013 hasAuthorship W4380201013A5036812155 @default.
• W4380201013 hasAuthorship W4380201013A5052662972 @default.
• W4380201013 hasAuthorship W4380201013A5069623368 @default.
• W4380201013 hasAuthorship W4380201013A5082022074 @default.
• W4380201013 hasConcept C115624301 @default.
• W4380201013 hasConcept C116569031 @default.
• W4380201013 hasConcept C159110408 @default.
• W4380201013 hasConcept C170493617 @default.
• W4380201013 hasConcept C178516000 @default.
• W4380201013 hasConcept C185592680 @default.
• W4380201013 hasConcept C2776428424 @default.
• W4380201013 hasConcept C41685203 @default.
• W4380201013 hasConcept C552990157 @default.

• next