FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380201217> ?p ?o ?g. }

• W4380201217 endingPage "103449" @default.
• W4380201217 startingPage "103449" @default.
• W4380201217 abstract "Deep brain stimulation (DBS) is an established treatment in patients of various ages with pharmaco-resistant neurological disorders. Surgical targeting and postoperative programming of DBS depend on the spatial location of the stimulating electrodes in relation to the surrounding anatomical structures, and on electrode connectivity to a specific distribution pattern within brain networks. Such information is usually collected using group-level analysis, which relies on the availability of normative imaging resources (atlases and connectomes). Analysis of DBS data in children with debilitating neurological disorders such as dystonia would benefit from such resources, especially given the developmental differences in neuroimaging data between adults and children. We assembled pediatric normative neuroimaging resources from open-access datasets in order to comply with age-related anatomical and functional differences in pediatric DBS populations. We illustrated their utility in a cohort of children with dystonia treated with pallidal DBS. We aimed to derive a local pallidal sweetspot and explore a connectivity fingerprint associated with pallidal stimulation to exemplify the utility of the assembled imaging resources.An average pediatric brain template (the MNI brain template 4.5-18.5 years) was implemented and used to localize the DBS electrodes in 20 patients from the GEPESTIM registry cohort. A pediatric subcortical atlas, analogous to the DISTAL atlas known in DBS research, was also employed to highlight the anatomical structures of interest. A local pallidal sweetspot was modeled, and its degree of overlap with stimulation volumes was calculated as a correlate of individual clinical outcomes. Additionally, a pediatric functional connectome of 100 neurotypical subjects from the Consortium for Reliability and Reproducibility was built to allow network-based analyses and decipher a connectivity fingerprint responsible for the clinical improvements in our cohort.We successfully implemented a pediatric neuroimaging dataset that will be made available for public use as a tool for DBS analyses. Overlap of stimulation volumes with the identified DBS-sweetspot model correlated significantly with improvement on a local spatial level (R = 0.46, permuted p = 0.019). The functional connectivity fingerprint of DBS outcomes was determined to be a network correlate of therapeutic pallidal stimulation in children with dystonia (R = 0.30, permuted p = 0.003).Local sweetspot and distributed network models provide neuroanatomical substrates for DBS-associated clinical outcomes in dystonia using pediatric neuroimaging surrogate data. Implementation of this pediatric neuroimaging dataset might help to improve the practice and pave the road towards a personalized DBS-neuroimaging analyses in pediatric patients." @default.
• W4380201217 created "2023-06-11" @default.
• W4380201217 creator A5002340019 @default.
• W4380201217 creator A5004368139 @default.
• W4380201217 creator A5005468329 @default.
• W4380201217 creator A5013035262 @default.
• W4380201217 creator A5015932829 @default.
• W4380201217 creator A5027255034 @default.
• W4380201217 creator A5031869394 @default.
• W4380201217 creator A5039681367 @default.
• W4380201217 creator A5043581700 @default.
• W4380201217 creator A5044208679 @default.
• W4380201217 creator A5048503646 @default.
• W4380201217 creator A5049532869 @default.
• W4380201217 creator A5053106125 @default.
• W4380201217 creator A5054591613 @default.
• W4380201217 creator A5056764413 @default.
• W4380201217 creator A5060370127 @default.
• W4380201217 creator A5070371296 @default.
• W4380201217 creator A5075373399 @default.
• W4380201217 date "2023-01-01" @default.
• W4380201217 modified "2023-10-12" @default.
• W4380201217 title "Neuroimaging-based analysis of DBS outcomes in pediatric dystonia: insights from the GEPESTIM registry" @default.
• W4380201217 cites W1569736468 @default.
• W4380201217 cites W1760829075 @default.
• W4380201217 cites W1778028538 @default.
• W4380201217 cites W1964722702 @default.
• W4380201217 cites W1970928383 @default.
• W4380201217 cites W1973776237 @default.
• W4380201217 cites W1980181971 @default.
• W4380201217 cites W1982339878 @default.
• W4380201217 cites W1994303356 @default.
• W4380201217 cites W1997960015 @default.
• W4380201217 cites W2006557707 @default.
• W4380201217 cites W2016049801 @default.
• W4380201217 cites W2016609376 @default.
• W4380201217 cites W2020745232 @default.
• W4380201217 cites W2046558738 @default.
• W4380201217 cites W2056455197 @default.
• W4380201217 cites W2059685025 @default.
• W4380201217 cites W2076261766 @default.
• W4380201217 cites W2087242089 @default.
• W4380201217 cites W2093745477 @default.
• W4380201217 cites W2110255132 @default.
• W4380201217 cites W2116649573 @default.
• W4380201217 cites W2117757868 @default.
• W4380201217 cites W2120731293 @default.
• W4380201217 cites W2122113495 @default.
• W4380201217 cites W2131134103 @default.
• W4380201217 cites W2135475851 @default.
• W4380201217 cites W2142106331 @default.
• W4380201217 cites W2147980755 @default.
• W4380201217 cites W2153614880 @default.
• W4380201217 cites W2168890449 @default.
• W4380201217 cites W2170301659 @default.
• W4380201217 cites W2175908672 @default.
• W4380201217 cites W2286236839 @default.
• W4380201217 cites W2346132822 @default.
• W4380201217 cites W2466722677 @default.
• W4380201217 cites W2510925043 @default.
• W4380201217 cites W2560079766 @default.
• W4380201217 cites W2622109244 @default.
• W4380201217 cites W2748717076 @default.
• W4380201217 cites W2763229272 @default.
• W4380201217 cites W2768053978 @default.
• W4380201217 cites W2902923903 @default.
• W4380201217 cites W2921745261 @default.
• W4380201217 cites W2950023299 @default.
• W4380201217 cites W2953279379 @default.
• W4380201217 cites W2966153590 @default.
• W4380201217 cites W2966629959 @default.
• W4380201217 cites W2977883299 @default.
• W4380201217 cites W3006150974 @default.
• W4380201217 cites W3033445582 @default.
• W4380201217 cites W3036911634 @default.
• W4380201217 cites W3042297668 @default.
• W4380201217 cites W3081565482 @default.
• W4380201217 cites W3105641049 @default.
• W4380201217 cites W3114453422 @default.
• W4380201217 cites W3119471363 @default.
• W4380201217 cites W3125868725 @default.
• W4380201217 cites W3183429248 @default.
• W4380201217 cites W3198227855 @default.
• W4380201217 cites W3199285286 @default.
• W4380201217 cites W3200217714 @default.
• W4380201217 cites W4200455315 @default.
• W4380201217 cites W4206497009 @default.
• W4380201217 cites W4210304932 @default.
• W4380201217 cites W4220989613 @default.
• W4380201217 cites W4225576461 @default.
• W4380201217 cites W4280605027 @default.
• W4380201217 cites W4308785563 @default.
• W4380201217 cites W4313558986 @default.
• W4380201217 doi "https://doi.org/10.1016/j.nicl.2023.103449" @default.
• W4380201217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37321142" @default.
• W4380201217 hasPublicationYear "2023" @default.
• W4380201217 type Work @default.
• W4380201217 citedByCount "1" @default.

• next