Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380201267> ?p ?o ?g. }
- W4380201267 abstract "Background The American Heart Association's framework ideal cardiovascular health (CVH) focuses on modifiable risk factors to reduce cardiovascular disease (CVD). Metabolomics provides important pathobiological insights into risk factors and CVD development. We hypothesized that metabolomic signatures associate with CVH status, and that metabolites, at least partially, mediate the association of CVH score with atrial fibrillation (AF) and heart failure (HF). Methods and Results We studied 3056 adults in the FHS (Framingham Heart Study) cohort to evaluate CVH score and incident outcomes of AF and HF. Metabolomics data were available in 2059 participants; mediation analysis was performed to evaluate the mediation of metabolites in the association of CVH score and incident AF and HF. In the smaller cohort (mean age, 54 years; 53% women), CVH score was associated with 144 metabolites, with 64 metabolites shared across key cardiometabolic components (body mass index, blood pressure, and fasting blood glucose) of the CVH score. In mediation analyses, 3 metabolites (glycerol, cholesterol ester 16:1, and phosphatidylcholine 32:1) mediated the association of CVH score with incident AF. Seven metabolites (glycerol, isocitrate, asparagine, glutamine, indole-3-proprionate, phosphatidylcholine C36:4, and lysophosphatidylcholine 18:2), partly mediated the association between CVH score and incident HF in multivariable-adjusted models. Conclusions Most metabolites that associated with CVH score were shared the most among 3 cardiometabolic components. Three main pathways: (1) alanine, glutamine, and glutamate metabolism; (2) citric acid cycle metabolism; and (3) glycerolipid metabolism mediated CVH score with HF. Metabolomics provides insights into how ideal CVH status contributes to the development of AF and HF." @default.
- W4380201267 created "2023-06-11" @default.
- W4380201267 creator A5004656494 @default.
- W4380201267 creator A5012677130 @default.
- W4380201267 creator A5017375628 @default.
- W4380201267 creator A5020787812 @default.
- W4380201267 creator A5031192936 @default.
- W4380201267 creator A5039389082 @default.
- W4380201267 creator A5049399632 @default.
- W4380201267 creator A5058158519 @default.
- W4380201267 creator A5061462830 @default.
- W4380201267 creator A5061678203 @default.
- W4380201267 creator A5064309113 @default.
- W4380201267 creator A5074117194 @default.
- W4380201267 creator A5075169530 @default.
- W4380201267 creator A5076996199 @default.
- W4380201267 creator A5081812583 @default.
- W4380201267 creator A5086482604 @default.
- W4380201267 date "2023-06-20" @default.
- W4380201267 modified "2023-09-26" @default.
- W4380201267 title "Metabolomic Profiles, Ideal Cardiovascular Health, and Risk of Heart Failure and Atrial Fibrillation: Insights From the Framingham Heart Study" @default.
- W4380201267 cites W1208435429 @default.
- W4380201267 cites W1935146112 @default.
- W4380201267 cites W1973667661 @default.
- W4380201267 cites W1986958862 @default.
- W4380201267 cites W2001820152 @default.
- W4380201267 cites W2009754435 @default.
- W4380201267 cites W2012821310 @default.
- W4380201267 cites W2013979638 @default.
- W4380201267 cites W2017771330 @default.
- W4380201267 cites W2035598079 @default.
- W4380201267 cites W2040380855 @default.
- W4380201267 cites W2042568900 @default.
- W4380201267 cites W2047241023 @default.
- W4380201267 cites W2047856648 @default.
- W4380201267 cites W2080993329 @default.
- W4380201267 cites W2086816631 @default.
- W4380201267 cites W2098397904 @default.
- W4380201267 cites W2100590447 @default.
- W4380201267 cites W2110065044 @default.
- W4380201267 cites W2122684027 @default.
- W4380201267 cites W2145063435 @default.
- W4380201267 cites W2150738902 @default.
- W4380201267 cites W2156848121 @default.
- W4380201267 cites W2162919259 @default.
- W4380201267 cites W2169156123 @default.
- W4380201267 cites W2211287272 @default.
- W4380201267 cites W2252854900 @default.
- W4380201267 cites W2288965173 @default.
- W4380201267 cites W2323862874 @default.
- W4380201267 cites W2391138069 @default.
- W4380201267 cites W2507295570 @default.
- W4380201267 cites W2515609721 @default.
- W4380201267 cites W2531513864 @default.
- W4380201267 cites W2548763544 @default.
- W4380201267 cites W2592965340 @default.
- W4380201267 cites W2599983619 @default.
- W4380201267 cites W2604899386 @default.
- W4380201267 cites W2733756507 @default.
- W4380201267 cites W2765098598 @default.
- W4380201267 cites W2767998629 @default.
- W4380201267 cites W2797537487 @default.
- W4380201267 cites W2801298184 @default.
- W4380201267 cites W2803081342 @default.
- W4380201267 cites W2806815486 @default.
- W4380201267 cites W2895200574 @default.
- W4380201267 cites W2901930603 @default.
- W4380201267 cites W2949402948 @default.
- W4380201267 cites W2952265240 @default.
- W4380201267 cites W3042817472 @default.
- W4380201267 cites W3092932642 @default.
- W4380201267 cites W3093514813 @default.
- W4380201267 cites W3110383283 @default.
- W4380201267 cites W3112803241 @default.
- W4380201267 cites W3119275146 @default.
- W4380201267 cites W3153262091 @default.
- W4380201267 cites W3158376506 @default.
- W4380201267 cites W3200314250 @default.
- W4380201267 cites W3214316807 @default.
- W4380201267 cites W4206373718 @default.
- W4380201267 cites W4235678124 @default.
- W4380201267 cites W4247991561 @default.
- W4380201267 cites W4253244719 @default.
- W4380201267 cites W4283017342 @default.
- W4380201267 cites W4286264509 @default.
- W4380201267 cites W4309224106 @default.
- W4380201267 cites W4310941138 @default.
- W4380201267 doi "https://doi.org/10.1161/jaha.122.028022" @default.
- W4380201267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37301766" @default.
- W4380201267 hasPublicationYear "2023" @default.
- W4380201267 type Work @default.
- W4380201267 citedByCount "1" @default.
- W4380201267 countsByYear W43802012672023 @default.
- W4380201267 crossrefType "journal-article" @default.
- W4380201267 hasAuthorship W4380201267A5004656494 @default.
- W4380201267 hasAuthorship W4380201267A5012677130 @default.
- W4380201267 hasAuthorship W4380201267A5017375628 @default.
- W4380201267 hasAuthorship W4380201267A5020787812 @default.
- W4380201267 hasAuthorship W4380201267A5031192936 @default.
- W4380201267 hasAuthorship W4380201267A5039389082 @default.