Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380201278> ?p ?o ?g. }
- W4380201278 endingPage "112635" @default.
- W4380201278 startingPage "112635" @default.
- W4380201278 abstract "Coat protein complex II (COPII) plays an integral role in the packaging of secretory cargoes within membrane-enclosed transport carriers that leave the endoplasmic reticulum (ER) from discrete subdomains. Lipid bilayer remodeling necessary for this process is driven initially by membrane penetration mediated by the Sar1 GTPase and further stabilized by assembly of a multilayered complex of several COPII proteins. However, the relative contributions of these distinct factors to transport carrier formation and protein trafficking remain unclear. Here, we demonstrate that anterograde cargo transport from the ER continues in the absence of Sar1, although the efficiency of this process is dramatically reduced. Specifically, secretory cargoes are retained nearly five times longer at ER subdomains when Sar1 is depleted, but they ultimately remain capable of being translocated to the perinuclear region of cells. Taken together, our findings highlight alternative mechanisms by which COPII promotes transport carrier biogenesis." @default.
- W4380201278 created "2023-06-11" @default.
- W4380201278 creator A5021765714 @default.
- W4380201278 creator A5026471672 @default.
- W4380201278 creator A5029200198 @default.
- W4380201278 creator A5052275455 @default.
- W4380201278 creator A5062279677 @default.
- W4380201278 creator A5071351828 @default.
- W4380201278 creator A5076782995 @default.
- W4380201278 creator A5090978275 @default.
- W4380201278 date "2023-06-01" @default.
- W4380201278 modified "2023-10-16" @default.
- W4380201278 title "The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER" @default.
- W4380201278 cites W1499112972 @default.
- W4380201278 cites W1531818302 @default.
- W4380201278 cites W1596180649 @default.
- W4380201278 cites W1894813487 @default.
- W4380201278 cites W1965183541 @default.
- W4380201278 cites W1969963064 @default.
- W4380201278 cites W1971476311 @default.
- W4380201278 cites W1973932471 @default.
- W4380201278 cites W1976177776 @default.
- W4380201278 cites W1995958002 @default.
- W4380201278 cites W1998822364 @default.
- W4380201278 cites W2004247840 @default.
- W4380201278 cites W2005125776 @default.
- W4380201278 cites W2010378383 @default.
- W4380201278 cites W2011370595 @default.
- W4380201278 cites W2013774412 @default.
- W4380201278 cites W2017178662 @default.
- W4380201278 cites W2020044636 @default.
- W4380201278 cites W2022542489 @default.
- W4380201278 cites W2023311735 @default.
- W4380201278 cites W2023848437 @default.
- W4380201278 cites W2024594546 @default.
- W4380201278 cites W2029152767 @default.
- W4380201278 cites W2031359038 @default.
- W4380201278 cites W2032486792 @default.
- W4380201278 cites W2040148851 @default.
- W4380201278 cites W2048552587 @default.
- W4380201278 cites W2048716263 @default.
- W4380201278 cites W2061455429 @default.
- W4380201278 cites W2064585995 @default.
- W4380201278 cites W2064689807 @default.
- W4380201278 cites W2065687264 @default.
- W4380201278 cites W2066454786 @default.
- W4380201278 cites W2068896961 @default.
- W4380201278 cites W2074897257 @default.
- W4380201278 cites W2078959581 @default.
- W4380201278 cites W2082423911 @default.
- W4380201278 cites W2085966620 @default.
- W4380201278 cites W2089515187 @default.
- W4380201278 cites W2104152706 @default.
- W4380201278 cites W2104360518 @default.
- W4380201278 cites W2109975639 @default.
- W4380201278 cites W2113776812 @default.
- W4380201278 cites W2123263958 @default.
- W4380201278 cites W2129224672 @default.
- W4380201278 cites W2129913763 @default.
- W4380201278 cites W2132569852 @default.
- W4380201278 cites W2140167060 @default.
- W4380201278 cites W2142469625 @default.
- W4380201278 cites W2144796443 @default.
- W4380201278 cites W2155624527 @default.
- W4380201278 cites W2158542693 @default.
- W4380201278 cites W2160513335 @default.
- W4380201278 cites W2169337490 @default.
- W4380201278 cites W2256152883 @default.
- W4380201278 cites W2337395026 @default.
- W4380201278 cites W2466179936 @default.
- W4380201278 cites W2517050669 @default.
- W4380201278 cites W2541068854 @default.
- W4380201278 cites W2591970391 @default.
- W4380201278 cites W2750856849 @default.
- W4380201278 cites W2763658724 @default.
- W4380201278 cites W2789549681 @default.
- W4380201278 cites W2885031263 @default.
- W4380201278 cites W2894689411 @default.
- W4380201278 cites W2899595813 @default.
- W4380201278 cites W2925209159 @default.
- W4380201278 cites W2944356096 @default.
- W4380201278 cites W2952808786 @default.
- W4380201278 cites W2969343565 @default.
- W4380201278 cites W3016592635 @default.
- W4380201278 cites W3122581625 @default.
- W4380201278 cites W3127087732 @default.
- W4380201278 cites W3134076312 @default.
- W4380201278 cites W3141435479 @default.
- W4380201278 cites W3142043333 @default.
- W4380201278 cites W3152848834 @default.
- W4380201278 cites W4210582335 @default.
- W4380201278 cites W4297093918 @default.
- W4380201278 cites W4308054829 @default.
- W4380201278 doi "https://doi.org/10.1016/j.celrep.2023.112635" @default.
- W4380201278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37300835" @default.
- W4380201278 hasPublicationYear "2023" @default.
- W4380201278 type Work @default.
- W4380201278 citedByCount "0" @default.