Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380201632> ?p ?o ?g. }
- W4380201632 endingPage "101669" @default.
- W4380201632 startingPage "101669" @default.
- W4380201632 abstract "Previous investigations have shown that D. viscosa herbal extract is often used to treat a variety of diseases. Therefore, the purpose of this study was to investigate any additional potential impacts on rat liver and kidney damage induced by diabetes. Streptozotocin (STZ) (60 mg/kg/day) was given as a single dosage to cause type 1 diabetes. After then, diabetic rats received oral doses of D. viscosa for four weeks at 150 and 300 mg/kg/day. Blood, liver, and kidney tissues were collected at the end of the treatment and examined. Analysis was made of the serum lipid profile, liver, and kidney functions, as well as blood biochemistry. Moreover, the levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), prostaglandin E-2 (PGE-2), and nitric oxide (NO) were estimated in serum. In liver and kidney samples, thiobarbituric acid reactive substances (TBARs) and reduced glutathione (GSH), as well as the pro-inflammatory cytokines and enzymatic activities of glutathione peroxidase (GPx), glutathione reeducates (GR), glutathione-S-transferase (GST), catalase (CAT), and superoxide dismutase (SOD) were analyzed. Histological changes in liver and kidney cross-sections were also observed. Our findings demonstrated that D. viscosa dramatically decreased pro-inflammatory indicators in blood, kidney, and liver tissues as well as blood glucose, and restored insulin levels, and lipid profiles. Additionally, it significantly raises the antioxidant enzyme activity SOD, CAT, GPx, and GST, while significantly lowering TBARs levels. The above-mentioned biochemical changes that took place in tissues were further supported by histological alterations. These findings imply that D. viscosa protects against STZ-induced hyperglycemia, aberrant lipid synthesis, and oxidative stress and that these benefits may be mediated by interacting with various targets to increase the levels of antioxidant enzymes in the liver and kidneys. Its mode of action and safety for use as medicine against various metabolic problems caused by diabetes require more research." @default.
- W4380201632 created "2023-06-11" @default.
- W4380201632 creator A5000121555 @default.
- W4380201632 creator A5005628933 @default.
- W4380201632 creator A5008126427 @default.
- W4380201632 creator A5024295770 @default.
- W4380201632 creator A5030747260 @default.
- W4380201632 creator A5031441244 @default.
- W4380201632 creator A5031481761 @default.
- W4380201632 creator A5059767903 @default.
- W4380201632 creator A5063694655 @default.
- W4380201632 creator A5065620055 @default.
- W4380201632 creator A5071602908 @default.
- W4380201632 creator A5078368929 @default.
- W4380201632 creator A5082927666 @default.
- W4380201632 creator A5088753450 @default.
- W4380201632 creator A5092135537 @default.
- W4380201632 date "2023-08-01" @default.
- W4380201632 modified "2023-10-05" @default.
- W4380201632 title "Protective role of Dodonaea viscosa extract against streptozotocin-induced hepatotoxicity and nephrotoxicity in rats" @default.
- W4380201632 cites W18212045 @default.
- W4380201632 cites W1968145736 @default.
- W4380201632 cites W1988244174 @default.
- W4380201632 cites W2010585155 @default.
- W4380201632 cites W2012937324 @default.
- W4380201632 cites W2013952480 @default.
- W4380201632 cites W2019227795 @default.
- W4380201632 cites W2019745252 @default.
- W4380201632 cites W2041531589 @default.
- W4380201632 cites W2048022930 @default.
- W4380201632 cites W2053500223 @default.
- W4380201632 cites W2056171430 @default.
- W4380201632 cites W2056235003 @default.
- W4380201632 cites W2060654505 @default.
- W4380201632 cites W2069318357 @default.
- W4380201632 cites W2074388946 @default.
- W4380201632 cites W2095612977 @default.
- W4380201632 cites W2113880168 @default.
- W4380201632 cites W2120293565 @default.
- W4380201632 cites W2125326130 @default.
- W4380201632 cites W2135847709 @default.
- W4380201632 cites W2254628042 @default.
- W4380201632 cites W2315269931 @default.
- W4380201632 cites W2571043486 @default.
- W4380201632 cites W2726219789 @default.
- W4380201632 cites W2794109705 @default.
- W4380201632 cites W2808432505 @default.
- W4380201632 cites W2890262909 @default.
- W4380201632 cites W2905186866 @default.
- W4380201632 cites W2943554146 @default.
- W4380201632 cites W2962762119 @default.
- W4380201632 cites W2966825489 @default.
- W4380201632 cites W2967298236 @default.
- W4380201632 cites W2980558423 @default.
- W4380201632 cites W2986942838 @default.
- W4380201632 cites W3036482718 @default.
- W4380201632 cites W3095580586 @default.
- W4380201632 cites W3096498336 @default.
- W4380201632 cites W3114609020 @default.
- W4380201632 cites W3122381186 @default.
- W4380201632 cites W4210803598 @default.
- W4380201632 cites W4310869933 @default.
- W4380201632 cites W4311757950 @default.
- W4380201632 cites W4321374207 @default.
- W4380201632 cites W4362640412 @default.
- W4380201632 cites W4367185835 @default.
- W4380201632 cites W647474305 @default.
- W4380201632 cites W925041399 @default.
- W4380201632 doi "https://doi.org/10.1016/j.jsps.2023.06.002" @default.
- W4380201632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37576853" @default.
- W4380201632 hasPublicationYear "2023" @default.
- W4380201632 type Work @default.
- W4380201632 citedByCount "0" @default.
- W4380201632 crossrefType "journal-article" @default.
- W4380201632 hasAuthorship W4380201632A5000121555 @default.
- W4380201632 hasAuthorship W4380201632A5005628933 @default.
- W4380201632 hasAuthorship W4380201632A5008126427 @default.
- W4380201632 hasAuthorship W4380201632A5024295770 @default.
- W4380201632 hasAuthorship W4380201632A5030747260 @default.
- W4380201632 hasAuthorship W4380201632A5031441244 @default.
- W4380201632 hasAuthorship W4380201632A5031481761 @default.
- W4380201632 hasAuthorship W4380201632A5059767903 @default.
- W4380201632 hasAuthorship W4380201632A5063694655 @default.
- W4380201632 hasAuthorship W4380201632A5065620055 @default.
- W4380201632 hasAuthorship W4380201632A5071602908 @default.
- W4380201632 hasAuthorship W4380201632A5078368929 @default.
- W4380201632 hasAuthorship W4380201632A5082927666 @default.
- W4380201632 hasAuthorship W4380201632A5088753450 @default.
- W4380201632 hasAuthorship W4380201632A5092135537 @default.
- W4380201632 hasBestOaLocation W43802016321 @default.
- W4380201632 hasConcept C126322002 @default.
- W4380201632 hasConcept C134018914 @default.
- W4380201632 hasConcept C181199279 @default.
- W4380201632 hasConcept C185592680 @default.
- W4380201632 hasConcept C2775838275 @default.
- W4380201632 hasConcept C2777352226 @default.
- W4380201632 hasConcept C2777504301 @default.
- W4380201632 hasConcept C2778004101 @default.