Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380201801> ?p ?o ?g. }
- W4380201801 endingPage "121108" @default.
- W4380201801 startingPage "121108" @default.
- W4380201801 abstract "It had been shown that lentinan (LNT) was mainly distributed in the liver after intravenous administration. The study aimed to investigate the integrated metabolic processes and mechanisms of LNT in the liver, as these have not been thoroughly explored. In current work, 5-([4,6-dichlorotriazin-2-yl] amino) fluorescein and cyanine 7 were used to label LNT for tracking its metabolic behavior and mechanisms. Near-infrared imaging demonstrated that LNT was captured mainly by the liver. Kupffer cell (KC) depletion reduced LNT liver localization and degradation in BALB/c mice. Moreover, experiments with Dectin-1 siRNA and Dectin-1/Syk signaling pathway inhibitors showed that LNT was mainly taken up by KCs via the Dectin-1/Syk pathway and promoted lysosomal maturation in KCs via this same pathway, which in turn promoted LNT degradation. These empirical findings offer novel insights into the metabolism of LNT in vivo and in vitro, which will facilitate the further application of LNT and other β-glucans." @default.
- W4380201801 created "2023-06-11" @default.
- W4380201801 creator A5002950746 @default.
- W4380201801 creator A5021628435 @default.
- W4380201801 creator A5022554270 @default.
- W4380201801 creator A5051079756 @default.
- W4380201801 creator A5072543841 @default.
- W4380201801 creator A5081242484 @default.
- W4380201801 creator A5090100523 @default.
- W4380201801 creator A5092135597 @default.
- W4380201801 date "2023-10-01" @default.
- W4380201801 modified "2023-10-09" @default.
- W4380201801 title "Metabolic degradation of polysaccharides from Lentinus edodes by Kupffer cells via the Dectin-1/Syk signaling pathway" @default.
- W4380201801 cites W1490817952 @default.
- W4380201801 cites W1966759451 @default.
- W4380201801 cites W1977579989 @default.
- W4380201801 cites W1997465916 @default.
- W4380201801 cites W2008699653 @default.
- W4380201801 cites W2009519656 @default.
- W4380201801 cites W2009523307 @default.
- W4380201801 cites W2020030635 @default.
- W4380201801 cites W2023538413 @default.
- W4380201801 cites W2035501441 @default.
- W4380201801 cites W2036890850 @default.
- W4380201801 cites W2059047819 @default.
- W4380201801 cites W2080992829 @default.
- W4380201801 cites W2081536518 @default.
- W4380201801 cites W2095082141 @default.
- W4380201801 cites W2107531246 @default.
- W4380201801 cites W2129533912 @default.
- W4380201801 cites W2145188183 @default.
- W4380201801 cites W2149714948 @default.
- W4380201801 cites W2170533080 @default.
- W4380201801 cites W2321111449 @default.
- W4380201801 cites W2425681130 @default.
- W4380201801 cites W2463475103 @default.
- W4380201801 cites W2561782720 @default.
- W4380201801 cites W2605155746 @default.
- W4380201801 cites W2801275484 @default.
- W4380201801 cites W2804886124 @default.
- W4380201801 cites W2884537942 @default.
- W4380201801 cites W2891048766 @default.
- W4380201801 cites W2900589767 @default.
- W4380201801 cites W2914567675 @default.
- W4380201801 cites W2920360233 @default.
- W4380201801 cites W2970365301 @default.
- W4380201801 cites W2971120492 @default.
- W4380201801 cites W3015805258 @default.
- W4380201801 cites W3046160285 @default.
- W4380201801 cites W3080665512 @default.
- W4380201801 cites W3086763887 @default.
- W4380201801 cites W3093068490 @default.
- W4380201801 cites W3113160205 @default.
- W4380201801 cites W3118460627 @default.
- W4380201801 cites W3130423531 @default.
- W4380201801 cites W3160013595 @default.
- W4380201801 cites W4205478049 @default.
- W4380201801 cites W4213174091 @default.
- W4380201801 cites W4213237806 @default.
- W4380201801 doi "https://doi.org/10.1016/j.carbpol.2023.121108" @default.
- W4380201801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37364942" @default.
- W4380201801 hasPublicationYear "2023" @default.
- W4380201801 type Work @default.
- W4380201801 citedByCount "1" @default.
- W4380201801 countsByYear W43802018012023 @default.
- W4380201801 crossrefType "journal-article" @default.
- W4380201801 hasAuthorship W4380201801A5002950746 @default.
- W4380201801 hasAuthorship W4380201801A5021628435 @default.
- W4380201801 hasAuthorship W4380201801A5022554270 @default.
- W4380201801 hasAuthorship W4380201801A5051079756 @default.
- W4380201801 hasAuthorship W4380201801A5072543841 @default.
- W4380201801 hasAuthorship W4380201801A5081242484 @default.
- W4380201801 hasAuthorship W4380201801A5090100523 @default.
- W4380201801 hasAuthorship W4380201801A5092135597 @default.
- W4380201801 hasConcept C100817775 @default.
- W4380201801 hasConcept C150903083 @default.
- W4380201801 hasConcept C185592680 @default.
- W4380201801 hasConcept C192989942 @default.
- W4380201801 hasConcept C207001950 @default.
- W4380201801 hasConcept C2776748855 @default.
- W4380201801 hasConcept C35174551 @default.
- W4380201801 hasConcept C42362537 @default.
- W4380201801 hasConcept C55493867 @default.
- W4380201801 hasConcept C62231903 @default.
- W4380201801 hasConcept C62478195 @default.
- W4380201801 hasConcept C86803240 @default.
- W4380201801 hasConcept C95444343 @default.
- W4380201801 hasConceptScore W4380201801C100817775 @default.
- W4380201801 hasConceptScore W4380201801C150903083 @default.
- W4380201801 hasConceptScore W4380201801C185592680 @default.
- W4380201801 hasConceptScore W4380201801C192989942 @default.
- W4380201801 hasConceptScore W4380201801C207001950 @default.
- W4380201801 hasConceptScore W4380201801C2776748855 @default.
- W4380201801 hasConceptScore W4380201801C35174551 @default.
- W4380201801 hasConceptScore W4380201801C42362537 @default.
- W4380201801 hasConceptScore W4380201801C55493867 @default.
- W4380201801 hasConceptScore W4380201801C62231903 @default.
- W4380201801 hasConceptScore W4380201801C62478195 @default.