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• W4380202425 abstract "BackgroundOne in seven women will develop breast cancer, making it the most common female cancer worldwide. Consequently, breast cancer related treatment including breast reconstruction has an impact on societal costs. Autologous fat transfer (AFT) is a relatively new breast reconstruction technique, however, several surgeries are necessary. This study investigates if AFT with pre-expansion is more cost-effective than implant-based reconstruction (IBR).MethodsSeven centers randomized patients from 2015 - 2021 to evaluate costs and EQ-5D-5L quality-adjusted life years (QALY) of AFT vs. IBR at 12 months postoperative. Costs were calculated including direct costs related to treatment and PRODISQ questionnaire to estimate productivity loss (indirect costs). Sensitivity analyses were performed for 10- and 30-years to estimate costs for patients replacing or explanting their breast implant over time.Results152 women of which 91 received AFT (mean age 49.3) and 80 IBR (mean age 49.1). Mean EQ-5D-5L QALY in the AFT group was 0.83, compared to the IBR group 0.79. Total costs for AFT at 12 months postoperative were higher compared to IBR (incremental cost: €6,763.59). Sensitivity analyses for 10- and 30-year scenarios showed mean incremental cost of respectively €2,586.56 and €680.22.ConclusionMean EQ-5D-5L QALY and costs were higher for AFT over the first year after reconstruction. However, these costs were low and therefore AFT was estimated to be more cost-effective over the 10- and 30- year period since no additional surgeries are necessary for this group. Larger cohorts are necessary to confirm AFT is more cost-effective on the long term." @default.
• W4380202425 created "2023-06-11" @default.
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• W4380202425 date "2023-09-01" @default.
• W4380202425 modified "2023-10-16" @default.
• W4380202425 title "A Dutch randomized controlled study shows autologous fat transfer with pre-expansion is more cost-effective in the long term than implants" @default.
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• W4380202425 doi "https://doi.org/10.1016/j.bjps.2023.06.013" @default.
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