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- W4380204493 abstract "ObjectiveEvidence regarding the role of cellular immunity in protecting against COVID-19 is emerging. To better assess immune status, simple and robust assays measuring specific T-cell responses associated with humoral responses are needed. We aimed to evaluate the Quan-T-Cell SARS-CoV-2 test for measuring cellular immune responses in vaccinated healthy and immunosuppressed subjects.MethodsT-cell responses were assessed in healthy vaccinated and unvaccinated and unexposed healthcare workers to determine the sensitivity and specificity of the EUROIMMUN SARS-CoV-2 Quan-T-Cell IGRA test performed on vaccinated kidney transplant recipients (KTRs).ResultsThe EUROIMMUN SARS-CoV-2 Quan-T-Cell IGRA test showed good sensitivity (87.2%) and specificity (92.3%) at the calculated 147 mIU/mL cutoff, with an 88.33% accuracy. In KTRs, specific cellular immunity was lower than the antibody response; however, those with a positive IGRA result produced as much IFN-γ as healthy individuals.ConclusionsThe EUROIMMUN SARS-CoV-2 Quan-T-Cell IGRA test showed good sensitivity and specificity for the detection of specific T-cell responses against the SARS-CoV-2 spike protein. These results present an additional tool for better management of COVID-19, especially in vulnerable populations." @default.
- W4380204493 created "2023-06-11" @default.
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- W4380204493 date "2023-06-01" @default.
- W4380204493 modified "2023-10-16" @default.
- W4380204493 title "Evaluation of a commercial interferon-γ release assay for the detection of SARS-CoV-2 T-cell response after vaccination" @default.
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- W4380204493 doi "https://doi.org/10.1016/j.heliyon.2023.e17186" @default.
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