FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380264876> ?p ?o ?g. }

• W4380264876 abstract "Introduction: Most critically ill COVID-19 patients have bronchitis, pneumonia, and acute respiratory distress syndrome (ARDS) due to excessive inflammatory conditions. Corticosteroids have largely been prescribed for the management of inflammation in these patients. However, long-term use of corticosteroids in patients with comorbidities such as metabolic, cardiovascular, and other inflammatory disorders is ideally not recommended due to safety issues. A potential and safer anti-inflammatory therapy is therefore the need of the hour. Withania somnifera (WS), a well-known herbal medicine used during the pandemic in India to prevent SARS-CoV2 infection, also possesses anti-inflammatory properties. Methods: In the present study, we, therefore, evaluated the effect of the aqueous extract of the roots of W. somnifera in the cell-based assays and in the experimental animal models of LPS-induced inflammation. Results: In the NCI-H460, A549 cells and human peripheral blood mononuclear cells (PBMCs) pre-treatment with W. somnifera reduced the LPS-induced expression of the pro-inflammatory cytokines. In addition, W. somnifera extract also showed potent anti-inflammatory activity in the lung tissues of BALB/c mice challenged intranasally with LPS. We observed a marked reduction in the neutrophil counts in the broncho-alveolar lavage (BAL) fluid, inflammatory cytokines, and fibrosis in the mice lungs pre-treated with W. somnifera. Results obtained thus suggest the potential utility of W. somnifera extract in reducing airway inflammation and recommend the clinical evaluation of W. somnifera extract in COVID-19 patients with a high propensity for lung inflammation." @default.
• W4380264876 created "2023-06-12" @default.
• W4380264876 creator A5030013291 @default.
• W4380264876 creator A5051317082 @default.
• W4380264876 creator A5052018787 @default.
• W4380264876 creator A5060712880 @default.
• W4380264876 creator A5069406255 @default.
• W4380264876 creator A5092139525 @default.
• W4380264876 date "2023-06-12" @default.
• W4380264876 modified "2023-10-04" @default.
• W4380264876 title "The aqueous root extract of Withania somnifera ameliorates LPS-induced inflammatory changes in the in vitro cell-based and mice models of inflammation" @default.
• W4380264876 cites W1585390661 @default.
• W4380264876 cites W1815264987 @default.
• W4380264876 cites W1975108570 @default.
• W4380264876 cites W2049579500 @default.
• W4380264876 cites W2124743010 @default.
• W4380264876 cites W2334443733 @default.
• W4380264876 cites W2364024733 @default.
• W4380264876 cites W2412799573 @default.
• W4380264876 cites W2551542040 @default.
• W4380264876 cites W2789727516 @default.
• W4380264876 cites W3004280078 @default.
• W4380264876 cites W3011230498 @default.
• W4380264876 cites W3012267054 @default.
• W4380264876 cites W3026032531 @default.
• W4380264876 cites W3035217157 @default.
• W4380264876 cites W3038063455 @default.
• W4380264876 cites W3040708582 @default.
• W4380264876 cites W3041667892 @default.
• W4380264876 cites W3046970198 @default.
• W4380264876 cites W3081100745 @default.
• W4380264876 cites W3082355253 @default.
• W4380264876 cites W3112429786 @default.
• W4380264876 cites W3139185320 @default.
• W4380264876 cites W3158313846 @default.
• W4380264876 cites W3187450969 @default.
• W4380264876 cites W3197085679 @default.
• W4380264876 cites W3202927745 @default.
• W4380264876 cites W3217378956 @default.
• W4380264876 cites W4205548943 @default.
• W4380264876 cites W4210642183 @default.
• W4380264876 cites W4283034403 @default.
• W4380264876 cites W4285173614 @default.
• W4380264876 cites W4285807056 @default.
• W4380264876 cites W4294771165 @default.
• W4380264876 cites W4295359175 @default.
• W4380264876 cites W4304688325 @default.
• W4380264876 cites W4319456488 @default.
• W4380264876 cites W4323364396 @default.
• W4380264876 cites W2193165651 @default.
• W4380264876 doi "https://doi.org/10.3389/fphar.2023.1139654" @default.
• W4380264876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37377934" @default.
• W4380264876 hasPublicationYear "2023" @default.
• W4380264876 type Work @default.
• W4380264876 citedByCount "0" @default.
• W4380264876 crossrefType "journal-article" @default.
• W4380264876 hasAuthorship W4380264876A5030013291 @default.
• W4380264876 hasAuthorship W4380264876A5051317082 @default.
• W4380264876 hasAuthorship W4380264876A5052018787 @default.
• W4380264876 hasAuthorship W4380264876A5060712880 @default.
• W4380264876 hasAuthorship W4380264876A5069406255 @default.
• W4380264876 hasAuthorship W4380264876A5092139525 @default.
• W4380264876 hasBestOaLocation W43802648761 @default.
• W4380264876 hasConcept C126322002 @default.
• W4380264876 hasConcept C142724271 @default.
• W4380264876 hasConcept C203014093 @default.
• W4380264876 hasConcept C204787440 @default.
• W4380264876 hasConcept C2776348555 @default.
• W4380264876 hasConcept C2776598214 @default.
• W4380264876 hasConcept C2776914184 @default.
• W4380264876 hasConcept C2777714996 @default.
• W4380264876 hasConcept C2778754761 @default.
• W4380264876 hasConcept C2780069950 @default.
• W4380264876 hasConcept C71924100 @default.
• W4380264876 hasConcept C98274493 @default.
• W4380264876 hasConceptScore W4380264876C126322002 @default.
• W4380264876 hasConceptScore W4380264876C142724271 @default.
• W4380264876 hasConceptScore W4380264876C203014093 @default.
• W4380264876 hasConceptScore W4380264876C204787440 @default.
• W4380264876 hasConceptScore W4380264876C2776348555 @default.
• W4380264876 hasConceptScore W4380264876C2776598214 @default.
• W4380264876 hasConceptScore W4380264876C2776914184 @default.
• W4380264876 hasConceptScore W4380264876C2777714996 @default.
• W4380264876 hasConceptScore W4380264876C2778754761 @default.
• W4380264876 hasConceptScore W4380264876C2780069950 @default.
• W4380264876 hasConceptScore W4380264876C71924100 @default.
• W4380264876 hasConceptScore W4380264876C98274493 @default.
• W4380264876 hasFunder F4320319722 @default.
• W4380264876 hasFunder F4320320717 @default.
• W4380264876 hasLocation W43802648761 @default.
• W4380264876 hasLocation W43802648762 @default.
• W4380264876 hasOpenAccess W4380264876 @default.
• W4380264876 hasPrimaryLocation W43802648761 @default.
• W4380264876 hasRelatedWork W2027682987 @default.
• W4380264876 hasRelatedWork W2052029498 @default.
• W4380264876 hasRelatedWork W2086459351 @default.
• W4380264876 hasRelatedWork W2369056050 @default.
• W4380264876 hasRelatedWork W2442937324 @default.
• W4380264876 hasRelatedWork W255382357 @default.
• W4380264876 hasRelatedWork W4251996317 @default.

• next