FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380265236> ?p ?o ?g. }

• W4380265236 abstract "Abstract Liver organoids derived from human pluripotent stem cells (hPSCs) allow elucidation of liver development and have great potential for drug discovery. However, current methods for generating liver organoids using biochemical substances do not realize the vascular network of the liver lobule, due to the lack of knowledge of the role of in vivo mechanical environments during liver development. Here, we investigate the role of cyclic mechanical stretch (cMS) to angiocrine signals of hepatoblasts (HBs) and endothelial progenitor cells (EPCs) using an organ-on-a-chip platform to emulate in vivo -like mechanical environments and hPSCs to recapitulate hepatic differentiation. RNA sequencing revealed that the expression of angiocrine signal genes, such as HGF and matrix metallopeptidase 9 ( MMP9 ), was increased by cMS in co-cultured HBs and EPCs. The secretion of HGF and MMP9 increased by 3.23-folds and 3.72-folds with cMS in the co-cultured HBs and EPCs but was not increased by cMS in the mono-cultured HBs and EPCs. Immunofluorescence micrographs with anti-KRT19, HGF, and MMP9 antibodies also revealed that cMS increased HGF and MMP9 expression when HBs and EPCs were co-cultured. cMS increased HGF and MMP9 expression and secretion when HBs and EPCs were co-cultured. Our findings provide new insights into the mechanical factors involved in the vascular network of human liver bud formation and liver organoid generation." @default.
• W4380265236 created "2023-06-12" @default.
• W4380265236 creator A5020968286 @default.
• W4380265236 creator A5050242122 @default.
• W4380265236 creator A5067131951 @default.
• W4380265236 creator A5072157266 @default.
• W4380265236 date "2023-06-11" @default.
• W4380265236 modified "2023-09-26" @default.
• W4380265236 title "Cyclic mechanical stretching stimuli promotes angiocrine signals during in vitro liver bud formation from human pluripotent stem cells" @default.
• W4380265236 cites W1473603974 @default.
• W4380265236 cites W1678482413 @default.
• W4380265236 cites W1779304243 @default.
• W4380265236 cites W1965089770 @default.
• W4380265236 cites W1970621119 @default.
• W4380265236 cites W1980247655 @default.
• W4380265236 cites W1981859071 @default.
• W4380265236 cites W1985342348 @default.
• W4380265236 cites W1986834354 @default.
• W4380265236 cites W1993623398 @default.
• W4380265236 cites W1999674210 @default.
• W4380265236 cites W2029026460 @default.
• W4380265236 cites W2048971561 @default.
• W4380265236 cites W2055458084 @default.
• W4380265236 cites W2076922024 @default.
• W4380265236 cites W2081704409 @default.
• W4380265236 cites W2086943348 @default.
• W4380265236 cites W2094857165 @default.
• W4380265236 cites W2102278945 @default.
• W4380265236 cites W2107554012 @default.
• W4380265236 cites W2123743609 @default.
• W4380265236 cites W2133059825 @default.
• W4380265236 cites W2138207763 @default.
• W4380265236 cites W2138977668 @default.
• W4380265236 cites W2153326882 @default.
• W4380265236 cites W2169675871 @default.
• W4380265236 cites W2292763365 @default.
• W4380265236 cites W2307471243 @default.
• W4380265236 cites W2335446275 @default.
• W4380265236 cites W2772609750 @default.
• W4380265236 cites W2782454362 @default.
• W4380265236 cites W2783745606 @default.
• W4380265236 cites W2785150634 @default.
• W4380265236 cites W2785727713 @default.
• W4380265236 cites W2806953728 @default.
• W4380265236 cites W2893871688 @default.
• W4380265236 cites W2907665228 @default.
• W4380265236 cites W2928665623 @default.
• W4380265236 cites W2958817003 @default.
• W4380265236 cites W2958872567 @default.
• W4380265236 cites W2959932413 @default.
• W4380265236 cites W3020618168 @default.
• W4380265236 cites W3035334103 @default.
• W4380265236 cites W3084111556 @default.
• W4380265236 cites W3087200754 @default.
• W4380265236 cites W314299795 @default.
• W4380265236 cites W4211240480 @default.
• W4380265236 cites W4295950911 @default.
• W4380265236 cites W4320922539 @default.
• W4380265236 doi "https://doi.org/10.1101/2023.06.11.544492" @default.
• W4380265236 hasPublicationYear "2023" @default.
• W4380265236 type Work @default.
• W4380265236 citedByCount "0" @default.
• W4380265236 crossrefType "posted-content" @default.
• W4380265236 hasAuthorship W4380265236A5020968286 @default.
• W4380265236 hasAuthorship W4380265236A5050242122 @default.
• W4380265236 hasAuthorship W4380265236A5067131951 @default.
• W4380265236 hasAuthorship W4380265236A5072157266 @default.
• W4380265236 hasConcept C104317684 @default.
• W4380265236 hasConcept C107459253 @default.
• W4380265236 hasConcept C127561419 @default.
• W4380265236 hasConcept C145103041 @default.
• W4380265236 hasConcept C170493617 @default.
• W4380265236 hasConcept C185592680 @default.
• W4380265236 hasConcept C201750760 @default.
• W4380265236 hasConcept C207001950 @default.
• W4380265236 hasConcept C2775997469 @default.
• W4380265236 hasConcept C2776996007 @default.
• W4380265236 hasConcept C28328180 @default.
• W4380265236 hasConcept C31695470 @default.
• W4380265236 hasConcept C54355233 @default.
• W4380265236 hasConcept C55493867 @default.
• W4380265236 hasConcept C86803240 @default.
• W4380265236 hasConcept C95444343 @default.
• W4380265236 hasConceptScore W4380265236C104317684 @default.
• W4380265236 hasConceptScore W4380265236C107459253 @default.
• W4380265236 hasConceptScore W4380265236C127561419 @default.
• W4380265236 hasConceptScore W4380265236C145103041 @default.
• W4380265236 hasConceptScore W4380265236C170493617 @default.
• W4380265236 hasConceptScore W4380265236C185592680 @default.
• W4380265236 hasConceptScore W4380265236C201750760 @default.
• W4380265236 hasConceptScore W4380265236C207001950 @default.
• W4380265236 hasConceptScore W4380265236C2775997469 @default.
• W4380265236 hasConceptScore W4380265236C2776996007 @default.
• W4380265236 hasConceptScore W4380265236C28328180 @default.
• W4380265236 hasConceptScore W4380265236C31695470 @default.
• W4380265236 hasConceptScore W4380265236C54355233 @default.
• W4380265236 hasConceptScore W4380265236C55493867 @default.
• W4380265236 hasConceptScore W4380265236C86803240 @default.
• W4380265236 hasConceptScore W4380265236C95444343 @default.
• W4380265236 hasLocation W43802652361 @default.

• next