FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380290438> ?p ?o ?g. }

• W4380290438 abstract "Mitochondrial protein import is essential for organellar biogenesis, and thereby for the sufficient supply of cytosolic ATP - which is particularly important for cells with high energy demands like neurons. This study explores the prospect of import machinery perturbation as a cause of neurodegeneration instigated by the accumulation of aggregating proteins linked to disease. We found that the aggregation-prone Tau variant (TauP301L) reduces the levels of components of the import machinery of the outer (TOM20, encoded by TOMM20) and inner membrane (TIM23, encoded by TIMM23) while associating with TOM40 (TOMM40). Intriguingly, this interaction affects mitochondrial morphology, but not protein import or respiratory function; raising the prospect of an intrinsic rescue mechanism. Indeed, TauP301L induced the formation of tunnelling nanotubes (TNTs), potentially for the recruitment of healthy mitochondria from neighbouring cells and/or the disposal of mitochondria incapacitated by aggregated Tau. Consistent with this, inhibition of TNT formation (and rescue) reveals Tau-induced import impairment. In primary neuronal cultures, TauP301L induced morphological changes characteristic of neurodegeneration. Interestingly, these effects were mirrored in cells where the import sites were blocked artificially. Our results reveal a link between aggregation-prone Tau and defective mitochondrial import relevant to disease." @default.
• W4380290438 created "2023-06-13" @default.
• W4380290438 creator A5017554134 @default.
• W4380290438 creator A5043806384 @default.
• W4380290438 creator A5067629922 @default.
• W4380290438 creator A5082068871 @default.
• W4380290438 date "2023-07-01" @default.
• W4380290438 modified "2023-10-15" @default.
• W4380290438 title "Aggregation prone Tau impairs mitochondrial import, which affects organelle morphology and neuronal complexity" @default.
• W4380290438 cites W1580520973 @default.
• W4380290438 cites W1968276382 @default.
• W4380290438 cites W1972553694 @default.
• W4380290438 cites W1975321314 @default.
• W4380290438 cites W1978323848 @default.
• W4380290438 cites W1981662243 @default.
• W4380290438 cites W1994030229 @default.
• W4380290438 cites W1996731829 @default.
• W4380290438 cites W2002364392 @default.
• W4380290438 cites W2004145886 @default.
• W4380290438 cites W2005354224 @default.
• W4380290438 cites W2013867688 @default.
• W4380290438 cites W2030300765 @default.
• W4380290438 cites W2035787181 @default.
• W4380290438 cites W2037075564 @default.
• W4380290438 cites W2053568595 @default.
• W4380290438 cites W2065222446 @default.
• W4380290438 cites W2071052050 @default.
• W4380290438 cites W2076241970 @default.
• W4380290438 cites W2081011462 @default.
• W4380290438 cites W2081791223 @default.
• W4380290438 cites W2083998249 @default.
• W4380290438 cites W2084520521 @default.
• W4380290438 cites W2101699102 @default.
• W4380290438 cites W2103269264 @default.
• W4380290438 cites W2111537613 @default.
• W4380290438 cites W2117526022 @default.
• W4380290438 cites W2124922792 @default.
• W4380290438 cites W2152165298 @default.
• W4380290438 cites W2154665893 @default.
• W4380290438 cites W2164136371 @default.
• W4380290438 cites W2167279371 @default.
• W4380290438 cites W2290400089 @default.
• W4380290438 cites W2341603395 @default.
• W4380290438 cites W2342860280 @default.
• W4380290438 cites W2517441590 @default.
• W4380290438 cites W2525041896 @default.
• W4380290438 cites W2548465653 @default.
• W4380290438 cites W2568628529 @default.
• W4380290438 cites W2580035316 @default.
• W4380290438 cites W2605036205 @default.
• W4380290438 cites W2605465471 @default.
• W4380290438 cites W2845880205 @default.
• W4380290438 cites W2908092937 @default.
• W4380290438 cites W2914114857 @default.
• W4380290438 cites W2950266092 @default.
• W4380290438 cites W2952702685 @default.
• W4380290438 cites W2956696709 @default.
• W4380290438 cites W2989453214 @default.
• W4380290438 cites W3026100224 @default.
• W4380290438 cites W3082327337 @default.
• W4380290438 cites W3118999391 @default.
• W4380290438 cites W3130924806 @default.
• W4380290438 cites W3141594118 @default.
• W4380290438 cites W3163756994 @default.
• W4380290438 cites W3205953904 @default.
• W4380290438 cites W4282929183 @default.
• W4380290438 cites W4284698668 @default.
• W4380290438 cites W4311937673 @default.
• W4380290438 cites W4312660805 @default.
• W4380290438 cites W4366983339 @default.
• W4380290438 cites W4380358839 @default.
• W4380290438 doi "https://doi.org/10.1242/jcs.260993" @default.
• W4380290438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37303235" @default.
• W4380290438 hasPublicationYear "2023" @default.
• W4380290438 type Work @default.
• W4380290438 citedByCount "1" @default.
• W4380290438 countsByYear W43802904382023 @default.
• W4380290438 crossrefType "journal-article" @default.
• W4380290438 hasAuthorship W4380290438A5017554134 @default.
• W4380290438 hasAuthorship W4380290438A5043806384 @default.
• W4380290438 hasAuthorship W4380290438A5067629922 @default.
• W4380290438 hasAuthorship W4380290438A5082068871 @default.
• W4380290438 hasBestOaLocation W43802904381 @default.
• W4380290438 hasConcept C104317684 @default.
• W4380290438 hasConcept C131934819 @default.
• W4380290438 hasConcept C142724271 @default.
• W4380290438 hasConcept C155432671 @default.
• W4380290438 hasConcept C168240541 @default.
• W4380290438 hasConcept C181199279 @default.
• W4380290438 hasConcept C2776925932 @default.
• W4380290438 hasConcept C2779134260 @default.
• W4380290438 hasConcept C28859421 @default.
• W4380290438 hasConcept C55493867 @default.
• W4380290438 hasConcept C57581600 @default.
• W4380290438 hasConcept C71924100 @default.
• W4380290438 hasConcept C86803240 @default.
• W4380290438 hasConcept C95444343 @default.
• W4380290438 hasConcept C98539663 @default.
• W4380290438 hasConceptScore W4380290438C104317684 @default.
• W4380290438 hasConceptScore W4380290438C131934819 @default.

• next