FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380290639> ?p ?o ?g. }

• W4380290639 endingPage "3445" @default.
• W4380290639 startingPage "3433" @default.
• W4380290639 abstract "Classic Hodgkin lymphoma (cHL) is characterized by multinucleated cells called Reed-Sternberg (RS) cells and genetic complexity. Although CD30 also characterizes cHL cells, its biological roles are not fully understood. In this report, we examined the link between CD30 and these characteristics of cHL cells. CD30 stimulation increased multinucleated cells resembling RS cells. We found chromatin bridges, a cause of mitotic errors, among the nuclei of multinucleated cells. CD30 stimulation induced DNA double-strand breaks (DSBs) and chromosomal imbalances. RNA sequencing showed significant changes in the gene expression by CD30 stimulation. We found that CD30 stimulation increased intracellular reactive oxygen species (ROS), which induced DSBs and multinucleated cells with chromatin bridges. The PI3K pathway was responsible for CD30-mediated generation of multinucleated cells by ROS. These results suggest that CD30 involves generation of RS cell-like multinucleated cells and chromosomal instability through induction of DSBs by ROS, which subsequently induces chromatin bridges and mitotic error. The results link CD30 not only to the morphological features of cHL cells, but also to the genetic complexity, both of which are characteristic of cHL cells." @default.
• W4380290639 created "2023-06-13" @default.
• W4380290639 creator A5000615874 @default.
• W4380290639 creator A5013090477 @default.
• W4380290639 creator A5027440746 @default.
• W4380290639 creator A5032378106 @default.
• W4380290639 creator A5047910903 @default.
• W4380290639 creator A5061061316 @default.
• W4380290639 creator A5066646106 @default.
• W4380290639 creator A5075374513 @default.
• W4380290639 date "2023-06-11" @default.
• W4380290639 modified "2023-09-30" @default.
• W4380290639 title "<scp>CD30</scp> induces <scp>Reed‐Sternberg</scp> cell‐like morphology and chromosomal instability in classic Hodgkin lymphoma cell lines" @default.
• W4380290639 cites W1541681455 @default.
• W4380290639 cites W1575623650 @default.
• W4380290639 cites W1728226545 @default.
• W4380290639 cites W1983862669 @default.
• W4380290639 cites W1990433019 @default.
• W4380290639 cites W2006897638 @default.
• W4380290639 cites W2017558550 @default.
• W4380290639 cites W2017956249 @default.
• W4380290639 cites W2019043312 @default.
• W4380290639 cites W2024984678 @default.
• W4380290639 cites W2026629308 @default.
• W4380290639 cites W2039620761 @default.
• W4380290639 cites W2046686330 @default.
• W4380290639 cites W2063205286 @default.
• W4380290639 cites W2079523831 @default.
• W4380290639 cites W2081518187 @default.
• W4380290639 cites W2087465293 @default.
• W4380290639 cites W2094377580 @default.
• W4380290639 cites W2099230762 @default.
• W4380290639 cites W2106820094 @default.
• W4380290639 cites W2107091218 @default.
• W4380290639 cites W2117247812 @default.
• W4380290639 cites W2165310632 @default.
• W4380290639 cites W2419269521 @default.
• W4380290639 cites W2547874472 @default.
• W4380290639 cites W2789405880 @default.
• W4380290639 cites W2796646673 @default.
• W4380290639 cites W2885656336 @default.
• W4380290639 cites W2907019762 @default.
• W4380290639 cites W3035722231 @default.
• W4380290639 cites W3137305120 @default.
• W4380290639 cites W3179127273 @default.
• W4380290639 cites W4380290639 @default.
• W4380290639 doi "https://doi.org/10.1111/cas.15874" @default.
• W4380290639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37302818" @default.
• W4380290639 hasPublicationYear "2023" @default.
• W4380290639 type Work @default.
• W4380290639 citedByCount "1" @default.
• W4380290639 countsByYear W43802906392023 @default.
• W4380290639 crossrefType "journal-article" @default.
• W4380290639 hasAuthorship W4380290639A5000615874 @default.
• W4380290639 hasAuthorship W4380290639A5013090477 @default.
• W4380290639 hasAuthorship W4380290639A5027440746 @default.
• W4380290639 hasAuthorship W4380290639A5032378106 @default.
• W4380290639 hasAuthorship W4380290639A5047910903 @default.
• W4380290639 hasAuthorship W4380290639A5061061316 @default.
• W4380290639 hasAuthorship W4380290639A5066646106 @default.
• W4380290639 hasAuthorship W4380290639A5075374513 @default.
• W4380290639 hasBestOaLocation W43802906391 @default.
• W4380290639 hasConcept C104317684 @default.
• W4380290639 hasConcept C136403682 @default.
• W4380290639 hasConcept C140752955 @default.
• W4380290639 hasConcept C153911025 @default.
• W4380290639 hasConcept C203014093 @default.
• W4380290639 hasConcept C2779338263 @default.
• W4380290639 hasConcept C2779390272 @default.
• W4380290639 hasConcept C2992779791 @default.
• W4380290639 hasConcept C3020616263 @default.
• W4380290639 hasConcept C30481170 @default.
• W4380290639 hasConcept C502942594 @default.
• W4380290639 hasConcept C54355233 @default.
• W4380290639 hasConcept C552990157 @default.
• W4380290639 hasConcept C70905583 @default.
• W4380290639 hasConcept C77076574 @default.
• W4380290639 hasConcept C83640560 @default.
• W4380290639 hasConcept C86803240 @default.
• W4380290639 hasConcept C93304396 @default.
• W4380290639 hasConcept C95444343 @default.
• W4380290639 hasConceptScore W4380290639C104317684 @default.
• W4380290639 hasConceptScore W4380290639C136403682 @default.
• W4380290639 hasConceptScore W4380290639C140752955 @default.
• W4380290639 hasConceptScore W4380290639C153911025 @default.
• W4380290639 hasConceptScore W4380290639C203014093 @default.
• W4380290639 hasConceptScore W4380290639C2779338263 @default.
• W4380290639 hasConceptScore W4380290639C2779390272 @default.
• W4380290639 hasConceptScore W4380290639C2992779791 @default.
• W4380290639 hasConceptScore W4380290639C3020616263 @default.
• W4380290639 hasConceptScore W4380290639C30481170 @default.
• W4380290639 hasConceptScore W4380290639C502942594 @default.
• W4380290639 hasConceptScore W4380290639C54355233 @default.
• W4380290639 hasConceptScore W4380290639C552990157 @default.
• W4380290639 hasConceptScore W4380290639C70905583 @default.
• W4380290639 hasConceptScore W4380290639C77076574 @default.
• W4380290639 hasConceptScore W4380290639C83640560 @default.
• W4380290639 hasConceptScore W4380290639C86803240 @default.

• next