Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380291268> ?p ?o ?g. }
- W4380291268 endingPage "199150" @default.
- W4380291268 startingPage "199150" @default.
- W4380291268 abstract "Fusion-associated small transmembrane (FAST) proteins can promote cell fusion, alter membrane permeability and trigger apoptosis to promote virus proliferation in orthoreoviruses. However, it is unknown whether FAST proteins perform these functions in aquareoviruses (AqRVs). Non-structural protein 17 (NS17) carried by grass carp reovirus Honghu strain (GCRV-HH196) belongs to the FAST protein family, and we preliminarily explored its relevance to virus infection. NS17 has similar domains to FAST protein NS16 of GCRV-873, comprising a transmembrane domain, a polybasic cluster, a hydrophobic patch and a polyproline motif. It was observed in the cytoplasm and the cell membrane. Overexpression of NS17 enhanced the efficiency of cell-cell fusion induced by GCRV-HH196 and promoted virus replication. Overexpression of NS17 also led to DNA fragmentation and reactive oxygen species (ROS) accumulation, and it triggered apoptosis. The findings illuminate the functions of NS17 in GCRV infection, and provide a reference for the development of novel antiviral strategies." @default.
- W4380291268 created "2023-06-13" @default.
- W4380291268 creator A5002426407 @default.
- W4380291268 creator A5009286692 @default.
- W4380291268 creator A5009577668 @default.
- W4380291268 creator A5010130651 @default.
- W4380291268 creator A5011087064 @default.
- W4380291268 creator A5017991798 @default.
- W4380291268 creator A5036609490 @default.
- W4380291268 creator A5063205781 @default.
- W4380291268 creator A5078246846 @default.
- W4380291268 creator A5084890604 @default.
- W4380291268 date "2023-09-01" @default.
- W4380291268 modified "2023-10-16" @default.
- W4380291268 title "Nonstructural protein NS17 of grass carp reovirus Honghu strain promotes virus infection by mediating cell-cell fusion and apoptosis" @default.
- W4380291268 cites W1521494919 @default.
- W4380291268 cites W1567789160 @default.
- W4380291268 cites W1645492839 @default.
- W4380291268 cites W1971878456 @default.
- W4380291268 cites W1976599392 @default.
- W4380291268 cites W1988693875 @default.
- W4380291268 cites W1999163520 @default.
- W4380291268 cites W2005826025 @default.
- W4380291268 cites W2008757142 @default.
- W4380291268 cites W2012215212 @default.
- W4380291268 cites W2017519756 @default.
- W4380291268 cites W2022890158 @default.
- W4380291268 cites W2024281316 @default.
- W4380291268 cites W2034871646 @default.
- W4380291268 cites W2042620115 @default.
- W4380291268 cites W2069106962 @default.
- W4380291268 cites W2077068107 @default.
- W4380291268 cites W2093266846 @default.
- W4380291268 cites W2099902384 @default.
- W4380291268 cites W2107277218 @default.
- W4380291268 cites W2107516157 @default.
- W4380291268 cites W2109203227 @default.
- W4380291268 cites W2125769389 @default.
- W4380291268 cites W2137675537 @default.
- W4380291268 cites W2138302361 @default.
- W4380291268 cites W2144551444 @default.
- W4380291268 cites W2144666557 @default.
- W4380291268 cites W2152207030 @default.
- W4380291268 cites W2160758530 @default.
- W4380291268 cites W2167171684 @default.
- W4380291268 cites W2192080449 @default.
- W4380291268 cites W2229274026 @default.
- W4380291268 cites W2232177416 @default.
- W4380291268 cites W2587481996 @default.
- W4380291268 cites W2766206172 @default.
- W4380291268 cites W2767549844 @default.
- W4380291268 cites W2782712177 @default.
- W4380291268 cites W2911711171 @default.
- W4380291268 cites W2941342171 @default.
- W4380291268 cites W2941665060 @default.
- W4380291268 cites W2956367114 @default.
- W4380291268 cites W2995627960 @default.
- W4380291268 cites W3156567397 @default.
- W4380291268 cites W4251751280 @default.
- W4380291268 cites W4283220703 @default.
- W4380291268 cites W611016427 @default.
- W4380291268 doi "https://doi.org/10.1016/j.virusres.2023.199150" @default.
- W4380291268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37302658" @default.
- W4380291268 hasPublicationYear "2023" @default.
- W4380291268 type Work @default.
- W4380291268 citedByCount "0" @default.
- W4380291268 crossrefType "journal-article" @default.
- W4380291268 hasAuthorship W4380291268A5002426407 @default.
- W4380291268 hasAuthorship W4380291268A5009286692 @default.
- W4380291268 hasAuthorship W4380291268A5009577668 @default.
- W4380291268 hasAuthorship W4380291268A5010130651 @default.
- W4380291268 hasAuthorship W4380291268A5011087064 @default.
- W4380291268 hasAuthorship W4380291268A5017991798 @default.
- W4380291268 hasAuthorship W4380291268A5036609490 @default.
- W4380291268 hasAuthorship W4380291268A5063205781 @default.
- W4380291268 hasAuthorship W4380291268A5078246846 @default.
- W4380291268 hasAuthorship W4380291268A5084890604 @default.
- W4380291268 hasBestOaLocation W43802912681 @default.
- W4380291268 hasConcept C104317684 @default.
- W4380291268 hasConcept C118892022 @default.
- W4380291268 hasConcept C123894998 @default.
- W4380291268 hasConcept C140704245 @default.
- W4380291268 hasConcept C1491633281 @default.
- W4380291268 hasConcept C159047783 @default.
- W4380291268 hasConcept C170493617 @default.
- W4380291268 hasConcept C190062978 @default.
- W4380291268 hasConcept C190283241 @default.
- W4380291268 hasConcept C24530287 @default.
- W4380291268 hasConcept C2522874641 @default.
- W4380291268 hasConcept C40767141 @default.
- W4380291268 hasConcept C41625074 @default.
- W4380291268 hasConcept C55493867 @default.
- W4380291268 hasConcept C62112901 @default.
- W4380291268 hasConcept C86803240 @default.
- W4380291268 hasConcept C95444343 @default.
- W4380291268 hasConceptScore W4380291268C104317684 @default.
- W4380291268 hasConceptScore W4380291268C118892022 @default.
- W4380291268 hasConceptScore W4380291268C123894998 @default.