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- W4380291392 abstract "Background: Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. Aim: In vivo evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials & methods: PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT. Results: The in vitro boron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model. Conclusion: PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT." @default.
- W4380291392 created "2023-06-13" @default.
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- W4380291392 date "2023-04-01" @default.
- W4380291392 modified "2023-09-23" @default.
- W4380291392 title "Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy" @default.
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- W4380291392 doi "https://doi.org/10.2217/nnm-2022-0330" @default.
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