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• W4380291497 abstract "Thiazolidione, conferring drug-like properties, is an important heterocycle that widely exists in medicinally relevant molecules. In this work, by efficiently assembling various DNA-tagged primary amines, abundant aryl isothiocyanates, and ethyl bromoacetate, we present a DNA-compatible three-component annulation to generate a 2-iminothiazolidin-4-one scaffold, which was further decorated via Knoevenagel condensation by employing (hetero)aryl and alkyl aldehydes. These thiazolidione derivatives should find broad use in focused DNA-encoded library construction." @default.
• W4380291497 created "2023-06-13" @default.
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• W4380291497 date "2023-06-12" @default.
• W4380291497 modified "2023-10-17" @default.
• W4380291497 title "DNA-Compatible Synthesis of Thiazolidione Derivatives via Three-Component Annulation and Knoevenagel Condensation" @default.
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• W4380291497 doi "https://doi.org/10.1021/acs.orglett.3c01482" @default.
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