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W4380291572 abstract "Limited data exist on COVID-19 vaccination efficacy in patients with acute myeloid leukemia and myelodysplasia with excess blasts (AML/MDS-EB2). We report results from a prospective study, PACE (Patients with AML and COVID-19 Epidemiology). 93 patients provided samples post-vaccine 2 or 3 (PV2, PV3). Antibodies against SARS-COV-2 spike antigen were detectable in all samples. Neutralization of the omicron variant was poorer than ancestral variants but improved PV3. In contrast, adequate T-cell reactivity to SARS-COV-2 spike protein was seen in only 16/47 (34%) patients PV2 and 23/52 (44%) PV3. Using regression models, disease response (not in CR/Cri), and increasing age predicted poor T cell response." @default.
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W4380291572 date "2023-06-12" @default.
W4380291572 modified "2023-09-27" @default.
W4380291572 title "Defective T‐cell response to <scp>COVID</scp>‐19 vaccination in acute myeloid leukaemia and myelodysplastic syndromes" @default.
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W4380291572 doi "https://doi.org/10.1111/bjh.18894" @default.
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