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- W4380291922 endingPage "4421" @default.
- W4380291922 startingPage "4407" @default.
- W4380291922 abstract "The habenula has been implicated in the pathogenesis of pain and analgesia, while evidence concerning its function in chronic low back pain (cLBP) is sparse. This study aims to investigate the resting-state functional connectivity (rsFC) and effective connectivity of the habenula in 52 patients with cLBP and 52 healthy controls (HCs) and assess the feasibility of distinguishing cLBP from HCs based on connectivity by machine learning methods. Our results indicated significantly enhanced rsFC of the habenula-left superior frontal cortex (SFC), habenula-right thalamus, and habenula-bilateral insular pathways as well as decreased rsFC of the habenula-pons pathway in cLBP patients compared to HCs. Dynamic causal modelling revealed significantly enhanced effective connectivity from the right thalamus to right habenula in cLBP patients compared with HCs. RsFC of the habenula-SFC was positively correlated with pain intensities and Hamilton Depression scores in the cLBP group. RsFC of the habenula-right insula was negatively correlated with pain duration in the cLBP group. Additionally, the combination of the rsFC of the habenula-SFC, habenula-thalamus, and habenula-pons pathways could reliably distinguish cLBP patients from HCs with an accuracy of 75.9% by support vector machine, which was validated in an independent cohort (N = 68, accuracy = 68.8%, p = .001). Linear regression and random forest could also distinguish cLBP and HCs in the independent cohort (accuracy = 73.9 and 55.9%, respectively). Overall, these findings provide evidence that cLBP may be associated with abnormal rsFC and effective connectivity of the habenula, and highlight the promise of machine learning in chronic pain discrimination." @default.
- W4380291922 created "2023-06-13" @default.
- W4380291922 creator A5007186238 @default.
- W4380291922 creator A5009961936 @default.
- W4380291922 creator A5016123060 @default.
- W4380291922 creator A5020334232 @default.
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- W4380291922 creator A5061215231 @default.
- W4380291922 creator A5066599847 @default.
- W4380291922 creator A5071386613 @default.
- W4380291922 creator A5076542561 @default.
- W4380291922 date "2023-06-12" @default.
- W4380291922 modified "2023-10-16" @default.
- W4380291922 title "Altered habenular connectivity in chronic low back pain: An <scp>fMRI</scp> and machine learning study" @default.
- W4380291922 cites W1531443818 @default.
- W4380291922 cites W1543649206 @default.
- W4380291922 cites W1608071409 @default.
- W4380291922 cites W1980905658 @default.
- W4380291922 cites W1983183519 @default.
- W4380291922 cites W1983348832 @default.
- W4380291922 cites W1987906186 @default.
- W4380291922 cites W1993442330 @default.
- W4380291922 cites W1998151455 @default.
- W4380291922 cites W2007296673 @default.
- W4380291922 cites W2012069883 @default.
- W4380291922 cites W2012889808 @default.
- W4380291922 cites W2015822010 @default.
- W4380291922 cites W2037043198 @default.
- W4380291922 cites W2042960263 @default.
- W4380291922 cites W2052644075 @default.
- W4380291922 cites W2061564920 @default.
- W4380291922 cites W2075878049 @default.
- W4380291922 cites W2080477987 @default.
- W4380291922 cites W2087658007 @default.
- W4380291922 cites W2098303658 @default.
- W4380291922 cites W2110183171 @default.
- W4380291922 cites W2113191728 @default.
- W4380291922 cites W2116136260 @default.
- W4380291922 cites W2117663940 @default.
- W4380291922 cites W2130266019 @default.
- W4380291922 cites W2135173838 @default.
- W4380291922 cites W2136718234 @default.
- W4380291922 cites W2137238320 @default.
- W4380291922 cites W2138407894 @default.
- W4380291922 cites W2143661428 @default.
- W4380291922 cites W2153635508 @default.
- W4380291922 cites W2157877920 @default.
- W4380291922 cites W2159940374 @default.
- W4380291922 cites W2166677951 @default.
- W4380291922 cites W2265460619 @default.
- W4380291922 cites W2297142014 @default.
- W4380291922 cites W2334094190 @default.
- W4380291922 cites W2413671571 @default.
- W4380291922 cites W2538170045 @default.
- W4380291922 cites W2583251805 @default.
- W4380291922 cites W2617782052 @default.
- W4380291922 cites W2619376700 @default.
- W4380291922 cites W2744595250 @default.
- W4380291922 cites W2757556887 @default.
- W4380291922 cites W2768592829 @default.
- W4380291922 cites W2770346636 @default.
- W4380291922 cites W2776260151 @default.
- W4380291922 cites W2787343838 @default.
- W4380291922 cites W2790410554 @default.
- W4380291922 cites W2795338757 @default.
- W4380291922 cites W2896068634 @default.
- W4380291922 cites W2902832378 @default.
- W4380291922 cites W2905788968 @default.
- W4380291922 cites W2911514809 @default.
- W4380291922 cites W2912654919 @default.
- W4380291922 cites W2913934201 @default.
- W4380291922 cites W2914061604 @default.
- W4380291922 cites W2915793503 @default.
- W4380291922 cites W2921721793 @default.
- W4380291922 cites W2921960971 @default.
- W4380291922 cites W2930682377 @default.
- W4380291922 cites W2951846486 @default.
- W4380291922 cites W3003871486 @default.
- W4380291922 cites W3030295450 @default.
- W4380291922 cites W3045032993 @default.
- W4380291922 cites W3048226693 @default.
- W4380291922 cites W3083511994 @default.
- W4380291922 cites W3112009591 @default.
- W4380291922 cites W3112211262 @default.
- W4380291922 cites W3128794716 @default.
- W4380291922 cites W3135028703 @default.
- W4380291922 cites W3143249574 @default.
- W4380291922 cites W3156499895 @default.
- W4380291922 cites W3162277144 @default.
- W4380291922 cites W3164240073 @default.
- W4380291922 cites W3177273944 @default.
- W4380291922 cites W3182971338 @default.
- W4380291922 cites W3192854425 @default.
- W4380291922 cites W3201759492 @default.
- W4380291922 cites W4220653098 @default.
- W4380291922 cites W4223454542 @default.
- W4380291922 cites W4225641529 @default.
- W4380291922 cites W4231211930 @default.